Compare Abilify vs. Clozaril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Abilify (aripiprazole)

Prescription only

Clozaril (Clozapine)

Prescription only
Helps control your thoughts and mood.

Abilify (aripiprazole) is good for treating psychosis and mania, and can help with depression. It's less likely to cause side effects than other antipsychotics.

4.3/ 7 average rating with 252 reviewsforAbilify
Helps control your thoughts and actions.

Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.

  • Effective at relieving psychotic symptoms and manic episodes.
  • More energizing than other antipsychotics.
  • Fewer side effects than other antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
  • Mild risk of extrapyramidal symptoms (EPS), a movement disorder that includes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find the one that works for you and that you can tolerate.
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
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Side effects
The Abilify (aripiprazole) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Drowsiness/Sedation
  • Salivation
  • Tachycardia
  • Dizziness/Vertigo
  • Constipation
  • Hypotension
  • Headache
  • Tremor
  • Syncope
  • Sweating
See more detailed side effects
Risks and warnings
  • Increased risk of death

    Elderly patients with dementia

  • Suicidal thoughts or behavior

    Age 24 years or younger

    ...and 1 more risk factors

  • Increased blood sugar and cholesterol, and weight gain

    People with diabetes

    ...and 1 more risk factors

  • Driving impairment


    ...and 1 more risk factors

See more detailed risks and warnings
  • Low blood pressure | Slow heartbeat | Fainting


    ...and 1 more risk factors

  • Seizures

    Seizure disorder

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

  • Increased risk of death

    Over 65 and having dementia

  • Increased blood sugar


  • Return of schizophrenic symptoms

    Stopping Clozaril (Clozapine) suddenly

See more detailed risks and warnings