Compare Abilify vs. fluphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Helps control your thoughts and mood. Abilify (aripiprazole) is good for treating psychosis and mania, and can help with depression. It's less likely to cause side effects than other antipsychotics.Treats schizophrenia and psychosis. Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.
Reviews & ratings
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Reviews for Abilify
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252 reviews
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Have you used Prolixin (fluphenazine)?
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Side effects
  • Dizziness 4%
  • Excess drooling 6%
  • Blurred vision 8%
  • Restlessness 8%
  • Fatigue 7%
  • Nausea 7%
  • Difficulty controlling movements 17%
  • Sleepiness 20%
  • Feeling jittery 2%
  • Weight gain 1%
More Abilify side effects »

The fluphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine side effects »
How it works
Abilify (aripiprazole) is an atypical antipsychotic. It stabilizes dopamine and serotonin levels in your brain to help control your thoughts and affect mood.Prolixin (fluphenazine) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.
Type of medication
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Liquid
  • Injection
Used for
Risk factors for serious side effects
  • Elderly patients with dementia
  • Age 24 years or younger
  • Use of antidepressant medications
  • People with diabetes
  • People with high cholesterol
Detailed Abilify (aripiprazole) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin (fluphenazine) risks & warnings »

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

No alcohol related info.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
No sleep related info.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Abilify (aripiprazole) can make you gain weight, which can also increase your blood sugar and cholesterol. If you're at risk for diabetes, high blood pressure or high cholestetrol, talk to your doctor how to lower your risk.
No weight related info.
Upsides and benefits
  • Effective at relieving psychotic symptoms and manic episodes.
  • More energizing than other antipsychotics.
  • Fewer side effects than other antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
Downsides and risks
  • Mild risk of extrapyramidal symptoms (EPS), a movement disorder that includes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find the one that works for you and that you can tolerate.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
Tips from our pharmacists for people taking the medication
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Makes you energized. Take in the morning to avoid difficulty sleeping.
  • For the first week, avoid activities that require you to be alert.
  • May increase cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Available in pills that you take daily, and as a monthly injection.
  • Can make you more sensitive to the sun. Wear sunscreen or protective clothing while outside.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Don't stop taking Prolixin (fluphenazine) suddenly. It can be dangerous.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Mix the concentrated form with at least 1/4 cup of fluids. Don't mix with caffeine, tea, or apple juice since it affects the absorption of Prolixin (fluphenazine).
Learn more
More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
More about fluphenazineSide effectsAlternativesFDA package insert
Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it