Compare Abilify vs. fluphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Abilify
(aripiprazole)

Prolixin
(fluphenazine)

Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Treats schizophrenia and psychosis. Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.
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Coupons for Abilify
Best available price for 30 (5mg) tablets of aripiprazole
Coupons for fluphenazine
Best available price for 60 (5mg) tablets of fluphenazine
Reviews & ratings
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4.29Abilify
Reviews for Abilify (aripiprazole)
44%
of people (All ages) say Abilify (aripiprazole) is worth it
40%
say it works well
34%
say it's a big hassle
252 reviews
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
Reviews for Prolixin (fluphenazine)
Not enough review data. Review it!
-44% worse vs. Abilify (aripiprazole)
Not enough review data. Review it!
-40% worse vs. Abilify (aripiprazole)
Not enough review data. Review it!
+34% better vs. Abilify (aripiprazole)
Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it
Side effects
Abilifyfluphenazine
  • Headache 4%
  • Agitation 2%
  • Sleep difficulty 5%
  • Anxiety 4%
  • Nausea 4%
  • Restlessness 9%
  • Constipation 4%
  • Vomiting 5%
  • Dizziness 3%
  • Indigestion 2%
More Abilify side effects »

The fluphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine side effects »
How it works
Abilifyfluphenazine
Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Prolixin (fluphenazine) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.
Type of medication
Abilifyfluphenazine
Prescription only
Prescription only
Available as
Abilifyfluphenazine
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Liquid
  • Injection
Used for
Abilifyfluphenazine
Risk factors for serious side effects
Abilifyfluphenazine
  • Elderly patients with dementia
  • Age 24 years or younger
  • History of heart problems
  • Drug interactions
  • People with diabetes
Detailed Abilify (aripiprazole) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin (fluphenazine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Abilifyfluphenazine
No alcohol related info.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
Sleep
Abilifyfluphenazine
No sleep related info.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
Weight
Abilifyfluphenazine
  • Least likely antipsychotic to cause weight gain.
  • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No weight related info.
Upsides and benefits
Abilifyfluphenazine
  • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
  • More energizing than other antipsychotics.
  • Fewer side effects than any other antipsychotics.
  • Least likely antipsychotic to cause weight gain.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
Downsides and risks
Abilifyfluphenazine
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
Tips from our pharmacists for people taking the medication
Abilifyfluphenazine
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Makes you energized. Take in the morning to avoid difficulty sleeping.
  • For the first week, avoid activities that require you to be alert.
  • May worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Can make you more sensitive to the sun. Wear sunscreen or protective clothing while outside.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Don't stop taking Prolixin (fluphenazine) suddenly. It can be dangerous.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Mix the concentrated form with at least 1/4 cup of fluids. Don't mix with caffeine, tea, or apple juice since it affects the absorption of Prolixin (fluphenazine).
Learn more
More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
More about fluphenazineSide effectsAlternativesFDA package insert
Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it