Compare Abilify vs. fluphenazine decanoate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Abilify
(aripiprazole)

Prolixin Decanoate
(fluphenazine decanoate)

Helps control your thoughts and mood. Abilify (aripiprazole) is good for treating psychosis and mania, and can help with depression. It's less likely to cause side effects than other antipsychotics.Treats schizophrenia or psychosis. Prolixin Decanoate (fluphenazine decanoate) is long-acting medicine for stabilizing your mood that must be given by a trained healthcare professional.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.29Abilify
Reviews for Abilify
44%
of people (All ages) say Abilify is worth it
40%
say it works well
34%
say it's a big hassle
252 reviews
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Have you used Prolixin Decanoate (fluphenazine decanoate)?
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Side effects
Abilifyfluphenazine decanoate
  • Sleepiness 20%
  • Difficulty controlling movements 17%
  • Fatigue 7%
  • Nausea 7%
  • Restlessness 8%
  • Blurred vision 8%
  • Excess drooling 6%
  • Dizziness 4%
  • Extreme restlessness 21%
  • Insomnia 6%
More Abilify side effects »

The fluphenazine decanoate FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine decanoate side effects »
How it works
Abilifyfluphenazine decanoate
Abilify (aripiprazole) is an atypical antipsychotic. It stabilizes dopamine and serotonin levels in your brain to help control your thoughts and affect mood.Prolixin Decanoate (fluphenazine decanoate) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.
Type of medication
Abilifyfluphenazine decanoate
Prescription onlyPrescription only
Available as
Abilifyfluphenazine decanoate
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Injection
Used for
Abilifyfluphenazine decanoate
Risk factors for serious side effects
Abilifyfluphenazine decanoate
  • Elderly patients with dementia
  • Age 24 years or younger
  • Use of antidepressant medications
  • People with diabetes
  • People with high cholesterol
Detailed Abilify (aripiprazole) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin Decanoate (fluphenazine decanoate) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Abilifyfluphenazine decanoate
No alcohol related info.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
Sleep
Abilifyfluphenazine decanoate
No sleep related info.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
Weight
Abilifyfluphenazine decanoate
  • Abilify (aripiprazole) can make you gain weight, which can also increase your blood sugar and cholesterol. If you're at risk for diabetes, high blood pressure or high cholestetrol, talk to your doctor how to lower your risk.
No weight related info.
Upsides and benefits
Abilifyfluphenazine decanoate
  • Effective at relieving psychotic symptoms and manic episodes.
  • More energizing than other antipsychotics.
  • Fewer side effects than other antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
  • Can be given less frequently than the oral, short-acting version.
  • Available in generic.
Downsides and risks
Abilifyfluphenazine decanoate
  • Mild risk of extrapyramidal symptoms (EPS), a movement disorder that includes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find the one that works for you and that you can tolerate.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can only be used if you're already stable on the short-acting version of this medicine.
Tips from our pharmacists for people taking the medication
Abilifyfluphenazine decanoate
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Makes you energized. Take in the morning to avoid difficulty sleeping.
  • For the first week, avoid activities that require you to be alert.
  • May increase cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Available in pills that you take daily, and as a monthly injection.
  • Can make you more sensitive to the sun, so wear sunscreen or protective clothing while outside.
  • Can affect how your body regulates your temperature, so drink plenty of liquids especially when you're exercising.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
Learn more
More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
More about fluphenazine decanoateSide effectsAlternativesFDA package insert
Have you used Prolixin Decanoate (fluphenazine decanoate)?
Worth itNot sureNot worth it