Compare Abilify vs. Invega

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Abilify
(Aripiprazole)

Invega
(Paliperidone)

Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.150943396226415Abilify
Reviews for Abilify (Aripiprazole)
42%
of people say Abilify (Aripiprazole) is worth it
38%
say it works well
35%
say it's a big hassle
Reviews for Invega (Paliperidone)
30%
12% vs. Abilify (Aripiprazole)
33%
5% vs. Abilify (Aripiprazole)
30%
+5% vs. Abilify (Aripiprazole)
Side effects
AbilifyInvega
  • Drowsiness 20%
  • Extrapyramidal disorder 17%
  • Relaxation or sleepiness 17%
  • Fatigue 15%
  • Restlessness 9%
  • Fever 8%
  • Vomiting 7%
  • Decreased appetite 5%
  • Excessive saliva 5%
  • Sleep difficulty 5%
More Abilify side effects »
  • Abnormally fast heart beat 7%
  • Anxiety 5%
  • Common cold 4%
  • Indigestion 4%
  • Constipation 3%
  • Positional low blood pressure 3%
  • Muscle weakness 3%
  • Headache 2%
  • Nausea 2%
  • Abdominal discomfort 2%
More Invega side effects »
How it works
AbilifyInvega
Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.
Type of medication
AbilifyInvega
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
AbilifyInvega
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Extended release
  • Injection
Used for (click to learn more)
AbilifyInvega
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Abilify (Aripiprazole)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Invega (Paliperidone)
Risk factors for serious side effects
AbilifyInvega
  • Elderly patients with dementia
  • Age 24 years or younger
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          • Phenylketonuria (PKU)
          Detailed Abilify (Aripiprazole) risks & warnings »
          • Elderly patients with dementia
              • History of heart problems
              • Drug interactions
                • People with diabetes
                • People with high cholesterol
                • People with diabetes
                • Alcohol
                • Taking other medicines that make you less alert
                  Detailed Invega (Paliperidone) risks & warnings »
                  Pregnancy category
                  AbilifyInvega
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  Alcohol
                  No specific alcohol-related info.No specific alcohol-related info.
                  Food
                  • Abilify (Aripiprazole) can increase your blood sugar and cholesterol. However, Abilify (Aripiprazole) is the least likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Kidneys and liver
                  No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                  Sex
                  No specific sex-related info.No specific sex-related info.
                  Sleep
                  • Makes you energized. Take in the morning to avoid difficulty sleeping.
                  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                  Weight
                  • Least likely antipsychotic to cause weight gain.
                  • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Sometimes causes weight gain and low blood pressure.
                  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Upsides and benefits
                  AbilifyInvega
                  • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
                  • More energizing than other antipsychotics.
                  • Fewer side effects than any other antipsychotics.
                  • Least likely antipsychotic to cause weight gain.
                  • Less likely to cause heart problems compared to some antipsychotics.
                  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
                  • Available as a generic, which is cheaper.
                  • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
                  • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
                  • Works just as well as other antipsychotic medicines.
                  • Less likely to cause heart or liver problems than some other antipsychotic medications.
                  Downsides and risks
                  AbilifyInvega
                  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
                  • Sometimes causes weight gain and low blood pressure.
                  • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • Not a good choice for elderly people who have dementia.
                  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  Tips from our pharmacists for people taking the medication
                  AbilifyInvega
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • Makes you energized. Take in the morning to avoid difficulty sleeping.
                  • For the first week, avoid activities that require you to be alert.
                  • May worsen cholesterol or blood sugar.
                  • Elderly people with dementia shouldn't take it.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
                  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                  • For the first week, avoid activities like driving that require you to be alert.
                  • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
                  • Elderly people who have dementia shouldn't take Invega (Paliperidone).
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  Learn more
                  More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
                  More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert