Compare Abilify vs. Latuda

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Abilify
(Aripiprazole)

Latuda
(Lurasidone)

Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Helps control your thoughts and mood. Latuda (Lurasidone) is good for treating schizophrenia and depression related to bipolar disorder. It's less likely to cause weight gain, cholesterol, blood sugar, and heart rhythm problems.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.150943396226415Abilify
Reviews for Abilify (Aripiprazole)
42%
of people say Abilify (Aripiprazole) is worth it
38%
say it works well
35%
say it's a big hassle
Reviews for Latuda (Lurasidone)
60%
+18% vs. Abilify (Aripiprazole)
60%
+22% vs. Abilify (Aripiprazole)
21%
+14% vs. Abilify (Aripiprazole)
Side effects
AbilifyLatuda
  • Drowsiness 20%
  • Extrapyramidal disorder 17%
  • Relaxation or sleepiness 17%
  • Fatigue 15%
  • Restlessness 9%
  • Fever 8%
  • Vomiting 7%
  • Decreased appetite 5%
  • Excessive saliva 5%
  • Sleep difficulty 5%
More Abilify side effects »
  • Restlessness 19%
  • Drowsiness 16%
  • Parkinsonism 12%
  • Muscle twitching 6%
  • Nausea 6%
  • Any side effect 3%
  • Agitation 3%
  • Anxiety 3%
  • Indigestion 2%
  • Dizziness 2%
More Latuda side effects »
How it works
AbilifyLatuda
Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Latuda (Lurasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar depression by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.
Type of medication
AbilifyLatuda
Antipsychotic
Atypical
Prescription only
Antipsychotic
2nd generation
Prescription only
Available as
AbilifyLatuda
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
Used for (click to learn more)
AbilifyLatuda
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Abilify (Aripiprazole)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Latuda (Lurasidone)
Risk factors for serious side effects
AbilifyLatuda
  • Elderly patients with dementia
  • Age 24 years or younger
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          • Phenylketonuria (PKU)
          Detailed Abilify (Aripiprazole) risks & warnings »
          • Elderly patients with dementia
          • Age 18 years or younger
            • Duration of treatment
            • Taking with alcohol
            • Taking other medicines that make you less alert
              • History of diabetes
              • History of high cholesterol
              Detailed Latuda (Lurasidone) risks & warnings »
              Pregnancy category
              AbilifyLatuda
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.
              • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
              Food
              • Abilify (Aripiprazole) can increase your blood sugar and cholesterol. However, Abilify (Aripiprazole) is the least likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              • Take it once a day at the same time each day. It works faster when you take it with a small snack (at least 350 calories).
              • Latuda (Lurasidone) can increase your blood sugar and cholesterol. However, Latuda (Lurasidone) is the least likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              • Makes you energized. Take in the morning to avoid difficulty sleeping.
              No specific sleep-related info.
              Weight
              • Least likely antipsychotic to cause weight gain.
              • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              • Compared to other antipsychotics, it has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm.
              Upsides and benefits
              AbilifyLatuda
              • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
              • More energizing than other antipsychotics.
              • Fewer side effects than any other antipsychotics.
              • Least likely antipsychotic to cause weight gain.
              • Less likely to cause heart problems compared to some antipsychotics.
              • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
              • Available as a generic, which is cheaper.
              • Has been shown in clinical studies to help people felt better and experience improvements with their thoughts and mood.
              • It’s a newer type of medication and works differently than traditional antidepressants.
              • Can be taken alone or with other medications that manage your mood.
              • Compared to other antipsychotics, it has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm.
              Downsides and risks
              AbilifyLatuda
              • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
              • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
              • You might need routine blood tests to check how the medicine is affecting your body.
              • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
              • Certain antifungal and heart medicines can increase the amount of Latuda (Lurasidone) in your body and put you at risk for more side effects. Ask your doctor or pharmacist about any drug interactions between medicines you’re taking.
              • Can cause you to be more sensitive to heat and make it harder for your body to cool off.
              • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
              • Elderly people who have dementia shouldn't take Latuda (Lurasidone).
              Tips from our pharmacists for people taking the medication
              AbilifyLatuda
              • Takes 4 to 6 weeks to see full effects on thoughts and mood.
              • Makes you energized. Take in the morning to avoid difficulty sleeping.
              • For the first week, avoid activities that require you to be alert.
              • May worsen cholesterol or blood sugar.
              • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
              • Elderly people with dementia shouldn't take it.
              • Take it once a day at the same time each day. It works faster when you take it with a small snack (at least 350 calories).
              • Don’t eat grapefruit or drink grapefruit juice while taking Latuda (Lurasidone). It can negatively affect how Latuda (Lurasidone) works.
              • Can cause dizziness and nausea, so avoid activities that require you to be alert until you get used to it.
              • Usually takes 4 to 6 weeks to see the full effects on your thoughts and mood, so hang in there until you find the right dose that works for you.
              Learn more
              More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
              More about LatudaSide effectsReviews & ratingsAlternativesFDA package insert