Compare Abilify vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Abilify
(Aripiprazole)

Saphris
(Asenapine)

Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Coming soon.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.150943396226415Abilify
Reviews for Abilify (Aripiprazole)
42%
of people say Abilify (Aripiprazole) is worth it
38%
say it works well
35%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
AbilifySaphris
  • Drowsiness 20%
  • Extrapyramidal disorder 17%
  • Relaxation or sleepiness 17%
  • Fatigue 15%
  • Restlessness 9%
  • Fever 8%
  • Vomiting 7%
  • Decreased appetite 5%
  • Excessive saliva 5%
  • Sleep difficulty 5%
More Abilify side effects »

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »
How it works
AbilifySaphris
Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Coming soon.
Type of medication
AbilifySaphris
Antipsychotic
Atypical
Prescription only
Coming soon.
Available as
AbilifySaphris
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
Used for (click to learn more)
AbilifySaphris
  • Bipolar I disorder
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Abilify (Aripiprazole)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Saphris (Asenapine)
Risk factors for serious side effects
AbilifySaphris
  • Elderly patients with dementia
  • Age 24 years or younger
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          • Phenylketonuria (PKU)
          Detailed Abilify (Aripiprazole) risks & warnings »
          Coming soon.
          Pregnancy category
          AbilifySaphris
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Abilify (Aripiprazole) can increase your blood sugar and cholesterol. However, Abilify (Aripiprazole) is the least likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          • Makes you energized. Take in the morning to avoid difficulty sleeping.
          No specific sleep-related info.
          Weight
          • Least likely antipsychotic to cause weight gain.
          • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No specific weight-related info.
          Upsides and benefits
          AbilifySaphris
          • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
          • More energizing than other antipsychotics.
          • Fewer side effects than any other antipsychotics.
          • Least likely antipsychotic to cause weight gain.
          • Less likely to cause heart problems compared to some antipsychotics.
          • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
          • Available as a generic, which is cheaper.
          Coming soon.
          Downsides and risks
          AbilifySaphris
          • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
          • You might need routine blood tests to check how the medicine is affecting your body.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          Coming soon.
          Tips from our pharmacists for people taking the medication
          AbilifySaphris
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • Makes you energized. Take in the morning to avoid difficulty sleeping.
          • For the first week, avoid activities that require you to be alert.
          • May worsen cholesterol or blood sugar.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          Coming soon.
          Learn more
          More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
          More about SaphrisSide effectsReviews & ratingsFDA package insert