Compare Abilify vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Abilify
(Aripiprazole)

Saphris
(Asenapine)

Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Coming soon.
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Reviews & ratings
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4.29Abilify
Reviews for Abilify (Aripiprazole)
44%
of people (All ages) say Abilify (Aripiprazole) is worth it
40%
say it works well
34%
say it's a big hassle
252 reviews
Have you used Abilify (Aripiprazole)?
Worth itNot sureNot worth it

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Have you used Saphris (Asenapine)?
Worth itNot sureNot worth it
Side effects
AbilifySaphris
  • Headache 4%
  • Agitation 2%
  • Sleep difficulty 5%
  • Anxiety 4%
  • Nausea 4%
  • Restlessness 9%
  • Constipation 4%
  • Vomiting 5%
  • Dizziness 3%
  • Indigestion 2%
More Abilify side effects »

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »
How it works
AbilifySaphris
Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Coming soon.
Type of medication
AbilifySaphris
Prescription only
Available as
AbilifySaphris
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
Used for
AbilifySaphris
  • Bipolar I Disorder
Risk factors for serious side effects
AbilifySaphris
  • Elderly patients with dementia
  • Age 24 years or younger
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          • Phenylketonuria (PKU)
          Detailed Abilify (Aripiprazole) risks & warnings »
          Coming soon.
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Weight
          AbilifySaphris
          • Least likely antipsychotic to cause weight gain.
          • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No weight related info.
          Upsides and benefits
          AbilifySaphris
          • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
          • More energizing than other antipsychotics.
          • Fewer side effects than any other antipsychotics.
          • Least likely antipsychotic to cause weight gain.
          • Less likely to cause heart problems compared to some antipsychotics.
          • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
          • Available as a generic, which is cheaper.
          Coming soon
          Downsides and risks
          AbilifySaphris
          • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
          • You might need routine blood tests to check how the medicine is affecting your body.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          Coming soon
          Tips from our pharmacists for people taking the medication
          AbilifySaphris
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • Makes you energized. Take in the morning to avoid difficulty sleeping.
          • For the first week, avoid activities that require you to be alert.
          • May worsen cholesterol or blood sugar.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          Coming soon
          Learn more
          More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Abilify (Aripiprazole)?
          Worth itNot sureNot worth it
          More about SaphrisSide effectsReviews & ratingsFDA package insert
          Have you used Saphris (Asenapine)?
          Worth itNot sureNot worth it