Compare Abilify vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Abilify
(aripiprazole)

Seroquel
(quetiapine)

Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.
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Coupons for Abilify
Best available price for 30 (5mg) tablets of aripiprazole
Coupons for Seroquel
Best available price for 30 (25mg) tablets of quetiapine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.29Abilify
Reviews for Abilify (aripiprazole)
44%
of people (All ages) say Abilify (aripiprazole) is worth it
40%
say it works well
34%
say it's a big hassle
252 reviews
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
Reviews for Seroquel (quetiapine)
56%
+12% better vs. Abilify (aripiprazole)
50%
+10% better vs. Abilify (aripiprazole)
27%
+7% better vs. Abilify (aripiprazole)
250 reviews
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it
Side effects
AbilifySeroquel
  • Headache 4%
  • Agitation 2%
  • Sleep difficulty 5%
  • Anxiety 4%
  • Nausea 4%
  • Restlessness 9%
  • Constipation 4%
  • Vomiting 5%
  • Dizziness 3%
  • Indigestion 2%
More Abilify side effects »
  • Drowsiness 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased appetite 8%
  • Abnormally fast heart beat 8%
  • Vomiting 4%
  • Dry mouth 7%
  • Nasal congestion 4%
  • Weight increased 6%
More Seroquel side effects »
How it works
AbilifySeroquel
Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
AbilifySeroquel
Prescription only
Prescription only
Available as
AbilifySeroquel
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Extended release
Used for
AbilifySeroquel
Risk factors for serious side effects
AbilifySeroquel
  • Elderly patients with dementia
  • Age 24 years or younger
  • History of heart problems
  • Drug interactions
  • People with diabetes
Detailed Abilify (aripiprazole) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Seroquel (quetiapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
AbilifySeroquel
No food related info.
  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Sleep
AbilifySeroquel
No sleep related info.
  • Can cause dizziness, drowsiness, and low blood pressure.
Weight
AbilifySeroquel
  • Least likely antipsychotic to cause weight gain.
  • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Upsides and benefits
AbilifySeroquel
  • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
  • More energizing than other antipsychotics.
  • Fewer side effects than any other antipsychotics.
  • Least likely antipsychotic to cause weight gain.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
  • Effective at relieving psychotic symptoms and manic episodes.
  • Antipsychotic medicines are all about equally effective.
  • Fewer side effects than most antipsychotic medicines.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
Downsides and risks
AbilifySeroquel
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • In studies, less effective for people over age 40 for schizophrenia.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
Tips from our pharmacists for people taking the medication
AbilifySeroquel
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Makes you energized. Take in the morning to avoid difficulty sleeping.
  • For the first week, avoid activities that require you to be alert.
  • May worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness, drowsiness, and low blood pressure.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
Learn more
More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it