Compare Acetaminophen With Codeine vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol #3 (Acetaminophen / Codeine)

Prescription only
Treats mild to moderate pain.

Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

5.0/ 7 average rating with 581 reviewsforAcetaminophen With Codeine
Treats moderate to severe pain.

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

5.2/ 7 average rating with 1399 reviewsforPercocet
Upsides
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Oral solution
Price
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$6.2
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Reviews
581 
69%
think this treatment is worth it
41%
think this treatment works well
9%
think this treatment is a hassle

Have you used Tylenol #3 (Acetaminophen / Codeine)?

Leave a review
1399 
70%
think this treatment is worth it
49%
think this treatment works well
15%
think this treatment is a hassle

Have you used Percocet (Oxycodone / Acetaminophen)?

Leave a review
Side effects
The Tylenol #3 (Acetaminophen / Codeine) FDA package insert doesn’t have numbers about how common side effects are.
The Percocet (Oxycodone / Acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
No information currently available
  • Death from liver failure

    Current liver disease

    ...and 2 more risk factors

  • Death from lack of oxygen to the body (respiratory depression)

    Age 65 or greater

    ...and 3 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Tolerance and dependence

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Neonatal withdrawal syndrome

    Long-term use of opioids in mother

    ...and 1 more risk factors

  • Death from overdose (extended-release tablet)

    Children age 18 and younger

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

    ...and 1 more risk factors

See more detailed risks and warnings