Compare Acetaminophen With Codeine vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol #3
(Acetaminophen / Codeine)

Percocet
(Oxycodone / Acetaminophen)

Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Loading pricing data...
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.987455197132617Acetaminophen With Codeine
Reviews for Tylenol #3 (Acetaminophen / Codeine)
70%
of people (All ages) say Tylenol #3 (Acetaminophen / Codeine) is worth it
41%
say it works well
9%
say it's a big hassle
558 reviews
Have you used Tylenol #3 (Acetaminophen / Codeine)?
Worth itNot sureNot worth it
Reviews for Percocet (Oxycodone / Acetaminophen)
69%
1% vs. Tylenol #3 (Acetaminophen / Codeine)
49%
+8% vs. Tylenol #3 (Acetaminophen / Codeine)
15%
6% vs. Tylenol #3 (Acetaminophen / Codeine)
1389 reviews
Have you used Percocet (Oxycodone / Acetaminophen)?
Worth itNot sureNot worth it
Side effects
Acetaminophen With CodeinePercocet

The Acetaminophen With Codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen With Codeine side effects »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
How it works
Acetaminophen With CodeinePercocet
Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
Acetaminophen With CodeinePercocet
Pain reliever
Acetaminophen (APAP)
Opioid
Prescription only
Pain reliever
Opioid
Acetaminophen (APAP)
Prescription only
Available as
Acetaminophen With CodeinePercocet
  • Pill
  • Liquid
  • Pill
  • Oral solution
Used for (click to learn more)
Acetaminophen With CodeinePercocet
Risk factors for serious side effects
Acetaminophen With CodeinePercocet
Coming soon.
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Long-term use of opioids in mother
  • Breastfeeding while taking Percocet (Oxycodone / Acetaminophen)
  • Children age 18 and younger
  • Taking more than prescribed dose
  • Mixing with alcohol or drugs that interact with Percocet (Oxycodone / Acetaminophen)
    • Age 65 years or older
    • Circulation problems
    Detailed Percocet (Oxycodone / Acetaminophen) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    Acetaminophen With CodeinePercocet
    • Avoid alcohol.
    • Avoid alcohol.
    Food
    Acetaminophen With CodeinePercocet
    • Take it with food to lower the chance of an upset stomach.
    • Take it with food to lower the chance of an upset stomach.
    Kidneys and liver
    Acetaminophen With CodeinePercocet
    • Don't take more than instructed to prevent liver damage.
    • Don't take more than instructed to prevent liver damage.
    • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
    Pain
    Acetaminophen With CodeinePercocet
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Good for as-needed pain and control.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Generally considered stronger than Norco or other combination pain medicine for treating pain.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    Sleep
    Acetaminophen With CodeinePercocet
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    Upsides and benefits
    Acetaminophen With CodeinePercocet
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relieve for mild to moderate pain to improve quality of life.
    • Good for as-needed pain and control.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relief for moderate to severe pain to improve quality of life.
    • Generally considered stronger than Norco or other combination pain medicine for treating pain.
    • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    Downsides and risks
    Acetaminophen With CodeinePercocet
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
    • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Dizziness and drowsiness is common, but your body may adjust.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
    • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Dizziness and drowsiness is common, but your body may adjust.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    Tips from our pharmacists for people taking the medication
    Acetaminophen With CodeinePercocet
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    Learn more
    More about Acetaminophen With CodeineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Tylenol #3 (Acetaminophen / Codeine)?
    Worth itNot sureNot worth it
    More about PercocetSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Percocet (Oxycodone / Acetaminophen)?
    Worth itNot sureNot worth it