Compare Acetaminophen With Codeine vs. Tramadol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol #3
(acetaminophen / codeine)

Ultram
(tramadol)

Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.Treats moderate to severe pain. Ultram (tramadol) works well for pain. Although it's a little weaker than other opioids, it can still be addictive.
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Best available price for 20 (300mg/30mg) tablets of acetaminophen / codeine
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Best available price for 120 (50mg) tablets of tramadol
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.98Acetaminophen With Codeine
Reviews for Tylenol #3 (acetaminophen / codeine)
69%
of people (All ages) say Tylenol #3 (acetaminophen / codeine) is worth it
41%
say it works well
9%
say it's a big hassle
581 reviews
Have you used Tylenol #3 (acetaminophen / codeine)?
Worth itNot sureNot worth it
Reviews for Ultram (tramadol)
61%
-8% worse vs. Tylenol #3 (acetaminophen / codeine)
40%
-1% worse vs. Tylenol #3 (acetaminophen / codeine)
16%
-7% worse vs. Tylenol #3 (acetaminophen / codeine)
642 reviews
Have you used Ultram (tramadol)?
Worth itNot sureNot worth it
Side effects
Acetaminophen With CodeineTramadol

The Acetaminophen With Codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen With Codeine side effects »
  • Dizziness 26%
  • Constipation 24%
  • Nausea 24%
  • Headache 18%
  • Sleepiness 16%
  • Vomiting 9%
  • Itching 8%
  • Cns stimulation 7%
  • Muscle weakness 6%
  • Sweating 6%
More Tramadol side effects »
How it works
Acetaminophen With CodeineTramadol
Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.Ultram (tramadol) is an opioid pain reliever. Researchers don't know exactly how it works, but it alters certain brain chemicals to lower pain perception and improve mood.
Type of medication
Acetaminophen With CodeineTramadol
Prescription only
Prescription only
Available as
Acetaminophen With CodeineTramadol
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
Used for
Acetaminophen With CodeineTramadol
Risk factors for serious side effects
Acetaminophen With CodeineTramadol
    Coming soon.
    • Pregnancy
    • Age 65 or greater
    • Overdose
    • Using alcohol, benzodiazepines or other medicines that slow breathing
    • Taking more than the prescribed dose
    Detailed Ultram (tramadol) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    Acetaminophen With CodeineTramadol
    No interactions related info.
    • Ultram (tramadol) can interact with your other medicines, which can change how it affects your pain. Stopping these medicines while taking Ultram (tramadol) can make you more likely to have serious, life threatening side effects. Make sure your doctor and pharmacist know all the medicines you're taking, and let them know of any changes.
    Alcohol
    Acetaminophen With CodeineTramadol
    • Avoid alcohol.
    No alcohol related info.
    Food
    Acetaminophen With CodeineTramadol
    • Take it with food to lower the chance of an upset stomach.
    • Take Ultram (tramadol) with food to avoid an upset stomach.
    Kidneys and liver
    Acetaminophen With CodeineTramadol
    • Don't take more than instructed to prevent liver damage.
    • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
    Pain
    Acetaminophen With CodeineTramadol
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Good for as-needed pain and control.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
    • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
    • Ultram (tramadol) can interact with your other medicines, which can change how it affects your pain. Stopping these medicines while taking Ultram (tramadol) can make you more likely to have serious, life threatening side effects. Make sure your doctor and pharmacist know all the medicines you're taking, and let them know of any changes.
    Sleep
    Acetaminophen With CodeineTramadol
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    No sleep related info.
    Upsides and benefits
    Acetaminophen With CodeineTramadol
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relieve for mild to moderate pain to improve quality of life.
    • Good for as-needed pain and control.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
    • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
    • Has a lower chance of causing breathing problems compared to other typical opioids.
    • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
    Downsides and risks
    Acetaminophen With CodeineTramadol
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
    • Like other opioid pain relievers, Ultram (tramadol) has a high risk of addiction, abuse, misuse, overdose, and death.
    • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
    • It's a controlled substance regulated by the federal government. This means that your use of Ultram (tramadol) will be tracked to prevent potential prescription abuse.
    • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
    Tips from our pharmacists for people taking the medication
    Acetaminophen With CodeineTramadol
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    • Starts working in one hour and works best if you take it regularly.
    • Can make you dizzy or drowsy, so avoid activities that need you to be fully alert until you know how this medicine affects you.
    • Take Ultram (tramadol) with food to avoid an upset stomach.
    • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
    • Swallow the extended-release tablets whole. They're designed to release the drug slowly and breaking, crushing, or chewing them could cause a serious overdose.
    • Take the extended-release tablets exactly as your doctor and pharmacist tell you. If you forget, take it as soon as you remember. Don't take extra medicine to make up for a missed dose.
    Learn more
    More about Acetaminophen With CodeineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Tylenol #3 (acetaminophen / codeine)?
    Worth itNot sureNot worth it
    More about TramadolSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Ultram (tramadol)?
    Worth itNot sureNot worth it