Compare Aciphex vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aciphex (Rabeprazole)

Prescription only

Pepcid (Famotidine)

Prescription or OTC
Treats heartburn and ulcers.

Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.

Relieves heartburn.

Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.

3.7/ 5 average rating with 853 reviewsforPepcid
Upsides
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides
  • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Used for
Dosage forms
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
Price
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Reviews
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853 reviews so far
75%
saidit'sworth it
41%
saiditworked well
8%
saidit'sa big hassle

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Side effects
10possible side effects
  • Headache
    10%
  • Diarrhea
    5%
  • Nausea
    5%
  • Abdominal pain
    5%
  • Vomiting
    4%
  • Pain
    3%
  • Pharyngitis
    3%
  • Flatulence
    3%
  • Infection
    2%
  • Constipaton
    2%
See more detailed side effects
2possible side effects
  • Headache
    5%
  • Diarrhea
    2%
See more detailed side effects
Risks and risk factors
  • Hiding possible cancer
  • Severe stomach inflammation (atrophic gastritis)
    • Helicobacter pylori infection
    • Autoimmune disease
  • Severe diarrhea
    • Being hospitalized
    • Antibiotic use
  • Broken bones
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
  • Low vitamin or mineral levels
See more detailed risks and warnings
  • Hiding possible cancer
  • Increased side effects
    • Current kidney disease
  • Allergic reaction
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.