Compare Aciphex vs. Prevacid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aciphex
(Rabeprazole)

Prevacid
(Lansoprazole)

Treats heartburn and ulcers. Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.
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Side effects
AciphexPrevacid
  • Passing gas 2%
  • Pain 2%
  • Constipaton 1%
  • Infection 1%
  • Sore throat 1%
More Aciphex side effects »
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
How it works
AciphexPrevacid
Aciphex (Rabeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
AciphexPrevacid
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
AciphexPrevacid
  • Extended release
  • Extended release
  • Dissolving tablet extended release
Used for (click to learn more)
AciphexPrevacid
Risk factors for serious side effects
AciphexPrevacid
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Aciphex (Rabeprazole) risks & warnings »
        • Helicobacter pylori infection
        • Autoimmune disease
        • Being hospitalized
        • Antibiotic use
        • Osteoporosis
        • Age 50 or older
        • Using high medication doses
        • Long-term therapy (1 year or more)
        • Smoking
        • Use of other medications that weaken bones
          Detailed Prevacid (Lansoprazole) risks & warnings »
          Pregnancy category
          AciphexPrevacid
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          AciphexPrevacid
          • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
          • Lasts longer than other similar stomach medicines. Most people take it once a day.
          • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
          • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
          • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
          • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
          Downsides and risks
          AciphexPrevacid
          • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
          • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
          • There's no generic version available, so it can be expensive.
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
          • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
          • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
          Tips from our pharmacists for people taking the medication
          AciphexPrevacid
          • Can take a few days to start working.
          • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
          • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
          • Aciphex (Rabeprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Aciphex (Rabeprazole).
          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
          • Don't chew or crush capsules, but swallow them whole.
          • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
          • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
          Learn more
          More about AciphexSide effectsReviews & ratingsAlternativesFDA package insert
          More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert