Compare Aciphex vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aciphex
(rabeprazole)

Tagamet
(cimetidine)

Treats heartburn and ulcers. Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Treats heartburn. Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.
Reviews & ratings
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Have you used Aciphex (rabeprazole)?
Worth itNot sureNot worth it
Reviews for Tagamet
63%
+37% better vs. Aciphex
36%
+53% better vs. Aciphex
12%
+12% better vs. Aciphex
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Side effects
AciphexTagamet
  • Headache 10%
  • Diarrhea 5%
  • Nausea 5%
  • Abdominal pain 5%
  • Vomiting 4%
  • Sore throat 1%
  • Passing gas 2%
  • Pain 2%
More Aciphex side effects »
  • Headache 2%
More Tagamet side effects »
How it works
AciphexTagamet
Aciphex (Rabeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Tagamet (cimetidine) reduces acid production in your stomach.
Type of medication
AciphexTagamet
Prescription onlyPrescription or OTC
Available as
AciphexTagamet
  • Extended release
  • Pill
  • Liquid
Used for
AciphexTagamet
Risk factors for serious side effects
AciphexTagamet
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Aciphex (rabeprazole) risks & warnings »
  • Elderly
  • Kidney problems
  • Liver problems
  • Dementia
  • Asthma
Detailed Tagamet (cimetidine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
AciphexTagamet
  • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
No interactions related info.
Food
AciphexTagamet
  • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
No food related info.
Kidneys and liver
AciphexTagamet
No kidneys and liver related info.
  • Tagamet (cimetidine) can cause confusion if you have kidney or liver problems, dementia, or if you are over 60 years old. Talk to your doctor or pharmacist about alternative medicines if you have any of these conditions.
  • May not be the best option if you are elderly or have kidney or liver problems.
Pain
AciphexTagamet
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
No pain related info.
Upsides and benefits
AciphexTagamet
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
Downsides and risks
AciphexTagamet
  • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
Tips from our pharmacists for people taking the medication
AciphexTagamet
  • Can take a few days to start working.
  • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
  • Aciphex (Rabeprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Aciphex (Rabeprazole).
  • Take 30 minutes before eating for maximum heartburn relief.
  • Talk to your doctor if you don't see any improvement after 2 weeks.
  • Talk to your doctor if you end up using this medicine more than 2 times a week.
  • Let your doctor or pharmacist know about any other medicines or supplements that you are taking because Tagamet (cimetidine) can interfere with how a lot of other medicines work.
Learn more
More about AciphexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aciphex (rabeprazole)?
Worth itNot sureNot worth it
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it