Compare Aciphex vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aciphex
(rabeprazole)

Tagamet
(cimetidine)

Treats heartburn and ulcers. Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Relieves heartburn and acid tummy. Tagamet (Cimetidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Coupons for Tagamet
Best available price for 60 (400mg) tablets of cimetidine
Reviews & ratings
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Reviews for Aciphex (rabeprazole)
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of people (All ages) say Aciphex (rabeprazole) is worth it
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say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Aciphex (rabeprazole)?
Worth itNot sureNot worth it
Reviews for Tagamet (cimetidine)
63%
-37% worse vs. Aciphex (rabeprazole)
36%
-53% worse vs. Aciphex (rabeprazole)
12%
-12% worse vs. Aciphex (rabeprazole)
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Side effects
AciphexTagamet
  • Headache 10%
  • Diarrhea 5%
  • Nausea 5%
  • Abdominal pain 5%
  • Vomiting 4%
  • Sore throat 1%
  • Passing gas 2%
  • Pain 2%
More Aciphex side effects »
  • Abnormally large breasts in males 4%
  • Headache 2%
More Tagamet side effects »
How it works
AciphexTagamet
Aciphex (Rabeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Tagamet (Cimetidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
AciphexTagamet
Prescription only
Prescription or OTC
Available as
AciphexTagamet
  • Extended release
  • Pill
  • Liquid
Used for
AciphexTagamet
Risk factors for serious side effects
AciphexTagamet
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Aciphex (rabeprazole) risks & warnings »
  • Current kidney disease
  • Current liver disease
  • Age 50 or older
  • Current severe illness
  • Autoimmune disease
Detailed Tagamet (cimetidine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
AciphexTagamet
  • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • Has more drug interactions than zantac and pepcid.
Food
AciphexTagamet
  • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
No food related info.
Kidneys and liver
AciphexTagamet
No kidneys and liver related info.
  • People with kidney disease may need to take a lower dose.
Pain
AciphexTagamet
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
No pain related info.
Upsides and benefits
AciphexTagamet
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
  • Most people can take Cimetidine without any noticeable day-to-day side effects.
  • Cimetidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
Downsides and risks
AciphexTagamet
  • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Cimetidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Cimetidine (H2 blockers).
  • Has more drug interactions than zantac and pepcid.
  • Although rare, Cimetidine can cause large breasts or impotence for men who need to use high doses for 6 months or more. It's reversible though and should go away when you stop or if you change medication.
Tips from our pharmacists for people taking the medication
AciphexTagamet
  • Can take a few days to start working.
  • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
  • Aciphex (Rabeprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Aciphex (Rabeprazole).
  • Works best if you take it with a full glass of water.
  • Starts working in one hour.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease may need to take a lower dose.
  • Tell your doctor all of the medications that you use before taking Cimetidine to avoid drug interactions.
Learn more
More about AciphexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aciphex (rabeprazole)?
Worth itNot sureNot worth it
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it