Compare Aciphex vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aciphex (Rabeprazole)

Prescription only

Zantac 75 (ranitidine)

Prescription or OTC
Treats heartburn and ulcers.

Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.

Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

5.1/ 7 average rating with 1062 reviewsforZantac
Upsides
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
Downsides
  • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
Used for
Dosage forms
  • Extended release
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
Price
Lowest price near you
$544.34
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Reviews
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1062 
72%
think this treatment is worth it
44%
think this treatment works well
7%
think this treatment is a hassle

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Side effects
7possible side effects
  • Headache
    10%
  • Diarrhea
    5%
  • Nausea
    5%
  • Abdominal pain
    5%
  • Vomiting
    4%
  • Pain
    3%
  • Pharyngitis
    3%
See more detailed side effects
The Zantac 75 (ranitidine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Severe stomach inflammation (atrophic gastritis)

    Helicobacter pylori infection

    ...and 1 more risk factors

  • Severe diarrhea

    Being hospitalized

    ...and 1 more risk factors

  • Broken bones

    Osteoporosis

    ...and 5 more risk factors

See more detailed risks and warnings
  • Confusion

    Aged 60 years or older

    ...and 2 more risk factors

  • Acute porphyria

    Acute Porphyria

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

See more detailed risks and warnings