Compare Aciphex vs. Zantac

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Zantac 75

Treats heartburn and ulcers. Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
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Reviews for Zantac 75 (Ranitidine)
28% vs. Aciphex (Rabeprazole)
57% vs. Aciphex (Rabeprazole)
7% vs. Aciphex (Rabeprazole)
Side effects
  • Passing gas 2%
  • Pain 2%
  • Constipaton 1%
  • Infection 1%
  • Sore throat 1%
More Aciphex side effects »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
Aciphex (Rabeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Histamine blocker
Prescription or OTC
Available as
  • Extended release
  • Pill
  • Oral solution
  • Injection
Used for (click to learn more)
Risk factors for serious side effects
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Aciphex (Rabeprazole) risks & warnings »
        • Current kidney problems
        • Current liver problems
        • Acute Porphyria
        • History of Phenylketonuria (PKU)
        Detailed Zantac 75 (Ranitidine) risks & warnings »
        Pregnancy category
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        No specific alcohol-related info.No specific alcohol-related info.
        • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.
        • People with kidney disease may need to take a lower dose.
        • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
        No specific sex-related info.No specific sex-related info.
        No specific sleep-related info.No specific sleep-related info.
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
        • Lasts longer than other similar stomach medicines. Most people take it once a day.
        • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
        • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
        • Most people can take Ranitidine without any noticeable day-to-day side effects.
        • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
        • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
        • Available as both a generic and over-the-counter option, so it's pretty affordable.
        • Few drug interactions.
        Downsides and risks
        • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
        • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
        • There's no generic version available, so it can be expensive.
        • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
        • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
        Tips from our pharmacists for people taking the medication
        • Can take a few days to start working.
        • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
        • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
        • Aciphex (Rabeprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Aciphex (Rabeprazole).
        • Works best if you take it with a full glass of water.
        • Starts working in one hour.
        • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
        • People with kidney disease may need to take a lower dose.
        Learn more
        More about AciphexSide effectsReviews & ratingsAlternativesFDA package insert
        More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert