Compare Actonel vs. Boniva

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actonel
(Risedronate)

Boniva
(Ibandronate)

Prevents bone loss. Actonel (Risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle.Prevents bone loss. Boniva is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.783132530120482Actonel
Reviews for Actonel (Risedronate)
36%
of people say Actonel (Risedronate) is worth it
19%
say it works well
25%
say it's a big hassle
Reviews for Boniva (Ibandronate)
30%
6% vs. Actonel (Risedronate)
19%
Same vs. Actonel (Risedronate)
27%
2% vs. Actonel (Risedronate)
Side effects
ActonelBoniva

We haven’t found good data for Actonel side effects.

FDA side effect reports for Actonel »
  • Any serious side effect 3%
More Boniva side effects »
How it works
ActonelBoniva
Actonel (Risedronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Boniva (Ibandronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.
Type of medication
ActonelBoniva
BisphosphonatePrescription only
BisphosphonatePrescription only
Available as
ActonelBoniva
  • Pill
  • Extended release
  • Pill
  • Injection
Used for (click to learn more)
ActonelBoniva
Risk factors for serious side effects
ActonelBoniva
      • Oral or dental surgery
      • Cancer
      • Poor oral hygiene
          Detailed Actonel (Risedronate) risks & warnings »
              • Oral or dental surgery
              • Cancer
              • Poor oral hygiene
                  Detailed Boniva (Ibandronate) risks & warnings »
                  Pregnancy category
                  ActonelBoniva
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  Alcohol
                  No specific alcohol-related info.No specific alcohol-related info.
                  Food
                  • If you're taking the extended release medication, take it after your first meal of the day with at least a half cup of water.
                  • Stay sitting or standing, and Don't take any other medications, vitamins or supplements for at least 60 minutes after you take the tablet until you've had your first food of the day.
                  Kidneys and liver
                  No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                  Sex
                  No specific sex-related info.No specific sex-related info.
                  Sleep
                  No specific sleep-related info.No specific sleep-related info.
                  Weight
                  • Consider adding weight-bearing exercises as part of your exercise routine.
                  • Consider adding weight-bearing exercises as part of your exercise routine.
                  Upsides and benefits
                  ActonelBoniva
                  • Available in oral tablets that can be taken once or twice a month, once a week, or once a day.
                  • Available in generic.
                  • Available in oral tablets that can be given once a month or once a day.
                  • Also available as shot given into your vein every 3 months.
                  • Available in generic.
                  Downsides and risks
                  ActonelBoniva
                  • You have to remain upright for at least 30 minutes after you take the medication, which can be a problem if you have mobility issues.
                  • You have to take it first thing in the morning with a full glass of water.
                  • You have to remain upright for at least 60 minutes after you take the medication, which can be a problem if you have mobility issues.
                  • Only approved to treat and prevent osteoporosis in women who have gone through menopause.
                  • You have to take it first thing in the morning with a full glass of water.
                  Tips from our pharmacists for people taking the medication
                  ActonelBoniva
                  • If you're taking the fast release medication, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
                  • Don't eat or drink anything for 30 minutes after you've taken the fast release medication.
                  • If you're taking the extended release medication, take it after your first meal of the day with at least a half cup of water.
                  • Stay sitting or standing and Don't take any other medications, vitamins or supplements for at least 30 minutes after you take the medication.
                  • If you forget to take your dose, skip it and take it the following morning.
                  • Some of these medications are only taken once or twice a month, others are taken once a week and others once a day. Talk to your pharmacist if you're not sure.
                  • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
                  • Call your doctor if you develop pain in your jaw, hips or thighs.
                  • Keep taking your calcium and vitamin D.
                  • Consider adding weight-bearing exercises as part of your exercise routine.
                  • Can be taken as a tablet or as an intravenous infusion.
                  • Take the tablet first thing when you wake up by swallowing the whole pill with a full glass of plain water.
                  • Don't eat or drink anything for 60 minutes after you've taken the tablet.
                  • Stay sitting or standing, and Don't take any other medications, vitamins or supplements for at least 60 minutes after you take the tablet until you've had your first food of the day.
                  • Take the 150 mg tablet on the same day every month.
                  • If you forget to take the 150mg tablet on your chosen day each month, take it on the next day in the morning.
                  • Some of these medications are only taken once a month, others once a day. Talk to your pharmacist if you're not sure.
                  • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
                  • Call your doctor if you develop pain in your jaw, hips or thighs.
                  • Keep taking your calcium and vitamin D.
                  • Consider adding weight-bearing exercises as part of your exercise routine.
                  Learn more
                  More about ActonelSide effectsReviews & ratingsAlternativesFDA package insert
                  More about BonivaSide effectsReviews & ratingsAlternativesFDA package insert