Compare Actonel vs. Boniva

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actonel (risedronate)

Prescription only

Boniva (ibandronate)

Prescription only
Prevents bone loss and fracture.

Actonel (risedronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.

2.9/ 5 average rating with 83 reviewsforActonel
Prevents bone loss.

Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.

2.9/ 5 average rating with 64 reviewsforBoniva
Upsides
  • Actonel (risedronate) is one of the first choice medicines used for the treatment and prevention of osteoporosis.
  • Available in a cheaper, generic form.
  • Can take tablet form once or twice a month, once a week, or once a day.
  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
Downsides
  • Need to take Actonel (risedronate) on an empty stomach first thing in the morning with a full glass of water.
  • Requires the person taking this medicine to remain upright for at least 30 minutes after taking it, which can be a problem for those who have trouble sitting or standing.
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
Used for
Dosage forms
  • Pill
  • Delayed-release pill
  • Pill
  • Injection
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
83 reviews so far
36%
saidit'sworth it
19%
saiditworked well
25%
saidit'sa big hassle

Have you used Actonel (risedronate)?

Leave a review
64 reviews so far
31%
saidit'sworth it
20%
saiditworked well
27%
saidit'sa big hassle

Have you used Boniva (ibandronate)?

Leave a review
Side effects
33possible side effects
  • Infection
    31%
  • Back pain
    28%
  • Joint pain
    24%
  • Accidental injury
    17%
  • Generalized pain
    14%
  • Constipation
    13%
  • Stomach pain
    12%
  • Traumatic bone fracture
    12%
  • Flu-like symptoms
    11%
  • High blood pressure
    11%
  • Diarrhea
    11%
  • Indigestion
    11%
  • Nausea
    11%
  • Headache
    10%
  • Bronchitis
    10%
  • Urinary tract infection
    10%
  • Sinus infection
    9%
  • Swelling in the arms or legs
    8%
  • Joint problems
    7%
  • Muscle pain
    7%
  • Dizziness
    7%
  • Depression
    7%
  • Rash
    7%
  • Cataracts
    7%
  • Stuffy or runny nose
    6%
  • Sore throat
    6%
  • Increased cough
    6%
  • Weakness
    5%
  • Neck pain
    5%
  • Chest pain
    5%
  • Bone pain
    5%
  • Sleep difficulty
    5%
  • Allergic reaction
    4%
See more detailed side effects
22possible side effects
  • Abdominal pain
    8%
  • High blood pressure
    6%
  • Indigestion
    6%
  • Joint pain
    6%
  • Nausea
    5%
  • Diarrhea
    5%
  • Back pain
    5%
  • Constipation
    4%
  • Pain in arms or legs
    4%
  • Flu
    4%
  • Cold
    4%
  • Localized joint stiffness and pain
    3%
  • Bronchitis
    3%
  • Headache
    3%
  • Influenza-like illness
    3%
  • Muscle pain
    2%
  • Muscle cramp
    2%
  • Urinary tract infection
    2%
  • Upper respiratory tract infection
    2%
  • Dizziness
    2%
  • Rash
    2%
  • Sleep difficulty
    2%
See more detailed side effects
Risks and risk factors
  • Irritation and ulcers in the stomach and esophagus
    • History of ulcers, or other stomach or esophageal problems
    • History of difficulty swallowing
    • Unable to sit upright or stand for 30 minutes after taking the medicine
  • Pain in the bones and/or muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
  • Leg bone fractures
  • Low calcium in the blood
    • History of low calcium in the blood
See more detailed risks and warnings
  • Irritation and ulcers to the stomach and esophagus
    • Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)
    • History of ulcers, or other stomach or esophageal problems
    • History of difficulty swallowing
    • Unable to sit upright or stand for 60 minutes after taking the medicine
  • Pain in the bones and/or muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
    • Prolonged use of Boniva (ibandronate)
  • Leg bone fractures
  • Low calcium in the blood
    • History of low calcium in the blood
See more detailed risks and warnings