Compare Actonel vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actonel
(risedronate)

Evista
(raloxifene)

Prevents bone loss. Actonel (risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but taking it can be a hassle.Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Actonel
Best available price for 1 (1 tablet of 150mg) dose pack of risedronate
Coupons for Evista
Best available price for 30 (60mg) tablets of raloxifene
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.78Actonel
Reviews for Actonel (risedronate)
36%
of people (All ages) say Actonel (risedronate) is worth it
19%
say it works well
25%
say it's a big hassle
Have you used Actonel (risedronate)?
Worth itNot sureNot worth it
Reviews for Evista (raloxifene)
Not enough review data. Review it!
+64% better vs. Actonel (risedronate)
Not enough review data. Review it!
+81% better vs. Actonel (risedronate)
Not enough review data. Review it!
+25% better vs. Actonel (risedronate)
Have you used Evista (raloxifene)?
Worth itNot sureNot worth it
Side effects
ActonelEvista
  • Infection 1%
  • Back pain 2%
  • Joint pain 2%
  • Stomach pain 2%
  • Traumatic bone fracture 3%
  • High blood pressure 1%
More Actonel side effects »
  • Joint pain 2%
  • Flu syndrome 3%
  • Any side effect 2%
  • Hot flashes 4%
  • Bronchitis 1%
More Evista side effects »
How it works
ActonelEvista
Actonel (risedronate) is a bisphosphonate. It slows down osteoclasts, which are the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.
Type of medication
ActonelEvista
Prescription only
Prescription only
Available as
ActonelEvista
  • Pill
  • Pill
Used for
ActonelEvista
Risk factors for serious side effects
ActonelEvista
  • History of ulcers, or other stomach or esophageal problems
  • History of difficulty swallowing
  • Unable to sit upright or stand for 30 minutes after taking the medicine
  • Oral or dental surgery
  • Cancer
Detailed Actonel (risedronate) risks & warnings »
  • History of stroke
  • Heart and blood vessel problems
  • History of mini stroke (TIA)
  • Atrial fibrillation
  • Smoking
Detailed Evista (raloxifene) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
ActonelEvista
No alcohol related info.
  • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
Food
ActonelEvista
  • Although rare, breakdown of the jawbone has happened in people taking Actonel (risedronate). This is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, tell your surgeon that you are taking Actonel (risedronate) prior to any oral/dental procedures.
  • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
Kidneys and liver
ActonelEvista
No kidneys and liver related info.
  • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
Pain
ActonelEvista
  • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
No pain related info.
Upsides and benefits
ActonelEvista
  • Actonel (risedronate) is one of the first choice medicines to treat osteoporosis.
  • It is available in generic.
  • It is available in tablets that can be taken by mouth once or twice a month, once a week, or once a day.
  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
Downsides and risks
ActonelEvista
  • You have to take Actonel (risedronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 30 minutes after you take it, which can be a problem if you have trouble moving.
  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
Tips from our pharmacists for people taking the medication
ActonelEvista
  • If you're taking the immediate release medicine, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
  • Remain sitting or standing, and don't take any other medications, vitamins, or supplements for at least 30 minutes after you take Actonel (risedronate).
  • If you forget to take your dose, skip it and take it the following morning.
  • Keep taking your calcium and vitamin D.
  • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
  • If you develop pain in your jaw, hips, or thighs, call your doctor.
  • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
  • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
  • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
Learn more
More about ActonelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Actonel (risedronate)?
Worth itNot sureNot worth it
More about EvistaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Evista (raloxifene)?
Worth itNot sureNot worth it