Compare Actonel vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actonel
(Risedronate)

Evista
(Raloxifene)

Prevents bone loss. Actonel (Risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle.Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.
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Reviews & ratings
Button Group. All currently active
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3.783132530120482Actonel
Reviews for Actonel (Risedronate)
36%
of people say Actonel (Risedronate) is worth it
19%
say it works well
25%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
ActonelEvista

We haven’t found good data for Actonel side effects.

FDA side effect reports for Actonel »
  • Muscle spasms/leg cramps 4%
  • Leg cramps 3%
  • Sinus inflammation 3%
  • Leg or ankle swelling 2%
  • Muscle pain 2%
  • Sleep difficulty 2%
  • Rash 2%
  • Joint pain 2%
  • Weight gain 2%
  • Any side effect 1%
More Evista side effects »
How it works
ActonelEvista
Actonel (Risedronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.
Type of medication
ActonelEvista
BisphosphonatePrescription only
Osteoporosis
Selective estrogen receptor modulator
Prescription only
Available as
ActonelEvista
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
ActonelEvista
Risk factors for serious side effects
ActonelEvista
      • Oral or dental surgery
      • Cancer
      • Poor oral hygiene
          Detailed Actonel (Risedronate) risks & warnings »
          • History of stroke
          • Heart and blood vessel problems
          • History of mini stroke (TIA)
          • Atrial fibrillation
          • Smoking
          • High blood pressure
            • History of high triglycerides
              Detailed Evista (Raloxifene) risks & warnings »
              Pregnancy category
              ActonelEvista
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              XFDA pregnancy category (Unsafe)

              Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.
              • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
              Food
              • If you're taking the extended release medication, take it after your first meal of the day with at least a half cup of water.
              • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
              Kidneys and liver
              No specific kidneys and liver-related info.
              • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              • Consider adding weight-bearing exercises as part of your exercise routine.
              No specific weight-related info.
              Upsides and benefits
              ActonelEvista
              • Available in generic.
              • Available in oral tablets that can be taken once or twice a month, once a week, or once a day.
              • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
              • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
              • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
              Downsides and risks
              ActonelEvista
              • You have to take it first thing in the morning with a full glass of water.
              • You have to remain upright for at least 30 minutes after you take the medication, which can be a problem if you have mobility issues.
              • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
              • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
              • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
              • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
              Tips from our pharmacists for people taking the medication
              ActonelEvista
              • If you're taking the fast release medication, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
              • Don't eat or drink anything for 30 minutes after you've taken the fast release medication.
              • If you're taking the extended release medication, take it after your first meal of the day with at least a half cup of water.
              • Stay sitting or standing and Don't take any other medications, vitamins or supplements for at least 30 minutes after you take the medication.
              • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
              • Call your doctor if you develop pain in your jaw, hips or thighs.
              • Keep taking your calcium and vitamin D.
              • If you forget to take your dose, skip it and take it the following morning.
              • Some of these medications are only taken once or twice a month, others are taken once a week and others once a day. Talk to your pharmacist if you're not sure.
              • Consider adding weight-bearing exercises as part of your exercise routine.
              • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
              • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
              • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
              Learn more
              More about ActonelSide effectsReviews & ratingsAlternativesFDA package insert
              More about EvistaSide effectsReviews & ratingsAlternativesFDA package insert