Compare Actonel vs. Reclast

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actonel (risedronate)

Prescription only

Reclast (zoledronate)

Prescription only
Prevents bone loss and fracture.

Actonel (risedronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.

3.8/ 7 average rating with 83 reviewsforActonel
Prevents bone loss.

Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.

4.1/ 7 average rating with 39 reviewsforReclast
Upsides
  • Actonel (risedronate) is one of the first choice medicines used for the treatment and prevention of osteoporosis.
  • Available in a cheaper, generic form.
  • Can take tablet form once or twice a month, once a week, or once a day.
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
Downsides
  • Need to take Actonel (risedronate) on an empty stomach first thing in the morning with a full glass of water.
  • Requires the person taking this medicine to remain upright for at least 30 minutes after taking it, which can be a problem for those who have trouble sitting or standing.
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
Used for
Dosage forms
  • Pill
  • Delayed-release pill
  • Injection
Price
Lowest price near you
$66.3
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Lowest price near you
$27.04
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Reviews
83 
36%
think this treatment is worth it
19%
think this treatment works well
25%
think this treatment is a hassle

Have you used Actonel (risedronate)?

Leave a review
39 
28%
think this treatment is worth it
28%
think this treatment works well
36%
think this treatment is a hassle

Have you used Reclast (zoledronate)?

Leave a review
Side effects
10possible side effects
  • Infection
    31%
  • Back pain
    28%
  • Joint pain
    24%
  • Accidental injury
    17%
  • Generalized pain
    14%
  • Constipation
    13%
  • Stomach pain
    12%
  • Traumatic bone fracture
    12%
  • Flu-like symptoms
    11%
  • High blood pressure
    11%
See more detailed side effects
10possible side effects
  • Muscle aches
    20%
  • Fatigue
    18%
  • Headache
    15%
  • Muscle pain
    12%
  • Pain
    12%
  • Chills
    10%
  • Influenza-like illness
    9%
  • Stomach pain
    8%
  • Shortness of breath
    7%
  • Feeling unwell
    7%
See more detailed side effects
Risks and warnings
  • Irritation and ulcers in the stomach and esophagus

    History of ulcers, or other stomach or esophageal problems

    ...and 2 more risk factors

  • Problems in the jawbone

    Oral or dental surgery

    ...and 2 more risk factors

  • Low calcium in the blood

    History of low calcium in the blood

See more detailed risks and warnings
  • Problems in the jawbone

    Oral or dental surgery

    ...and 2 more risk factors

  • Low calcium in the blood

    Low parathyroid hormone

    ...and 2 more risk factors

  • Kidney injury

    Kidney disease

    ...and 3 more risk factors

See more detailed risks and warnings