Compare Actonel vs. Reclast

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actonel
(risedronate)

Reclast
(zoledronate)

Prevents bone loss. Actonel (risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but taking it can be a hassle.Prevents bone loss. Reclast (Zoledronate) is a first-choice treatment for osteoporosis and is available as a generic, but you have to see a doctor to get each dose.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for
Prices and coupon for 1 (1 tablet of 150mg) dose pack of risedronate
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.78Actonel
Reviews for Actonel (risedronate)
36%
of people (All ages) say Actonel (risedronate) is worth it
19%
say it works well
25%
say it's a big hassle
Have you used Actonel (risedronate)?
Worth itNot sureNot worth it
Reviews for Reclast (zoledronate)
28%
-8% worse vs. Actonel (risedronate)
28%
+9% better vs. Actonel (risedronate)
36%
-11% worse vs. Actonel (risedronate)
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
Side effects
ActonelReclast
  • Infection 1%
  • Back pain 2%
  • Joint pain 2%
  • Stomach pain 2%
  • Traumatic bone fracture 3%
  • High blood pressure 1%
More Actonel side effects »
  • Joint pain 4%
  • Fever 13%
  • High blood pressure 1%
  • Headache 4%
  • Muscle pain 8%
  • Pain in extremity 1%
  • Influenza-like illness 6%
  • Nausea 4%
  • Pain 20%
  • Acute phase reaction 20%
More Reclast side effects »
How it works
ActonelReclast
Actonel (risedronate) is a bisphosphonate. It slows down osteoclasts, which are the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.Reclast (Zoledronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.
Type of medication
ActonelReclast
Prescription only
Prescription only
Available as
ActonelReclast
  • Pill
  • Injection
Used for
ActonelReclast
Risk factors for serious side effects
ActonelReclast
  • History of ulcers, or other stomach or esophageal problems
  • History of difficulty swallowing
  • Unable to sit upright or stand for 30 minutes after taking the medicine
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
      • History of low calcium in the blood
      Detailed Actonel (risedronate) risks & warnings »
        • Oral or dental surgery
        • Cancer
        • Poor oral hygiene
            Detailed Reclast (zoledronate) risks & warnings »
            Pregnancy

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Food
            ActonelReclast
            • Although rare, breakdown of the jawbone has happened in people taking Actonel (risedronate). This is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, tell your surgeon that you are taking Actonel (risedronate) prior to any oral/dental procedures.
            • People on Reclast (Zoledronate) have reported breakdown of the jaw bone. This is rare. This can happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain, swelling or an infection in your jaw, talk to your doctor right away. Also, tell your surgeon that you are taking Reclast (Zoledronate).
            Pain
            ActonelReclast
            • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
            No pain related info.
            Upsides and benefits
            ActonelReclast
            • Actonel (risedronate) is one of the first choice medicines to treat osteoporosis.
            • It is available in generic.
            • It is available in tablets that can be taken by mouth once or twice a month, once a week, or once a day.
            • Available in generic.
            • You only have to take this once a year.
            Downsides and risks
            ActonelReclast
            • You have to take Actonel (risedronate) first thing in the morning with a full glass of water.
            • You have to remain upright for at least 30 minutes after you take it, which can be a problem if you have trouble moving.
            • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
            Tips from our pharmacists for people taking the medication
            ActonelReclast
            • If you're taking the immediate release medicine, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
            • Remain sitting or standing, and don't take any other medications, vitamins, or supplements for at least 30 minutes after you take Actonel (risedronate).
            • If you forget to take your dose, skip it and take it the following morning.
            • Keep taking your calcium and vitamin D.
            • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
            • If you develop pain in your jaw, hips, or thighs, call your doctor.
            • Given as an intravenous infusion.
            • Eat normally and drink at least two glasses of liquid before your infusion.
            • Talk to your doctor if you develop swelling, pain, or a sore in your jaw.
            • Call your doctor if you develop pain in your hips, thighs or legs.
            • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
            • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
            • Drink plenty of liquids while you're on this medication.
            Learn more
            More about ActonelSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Actonel (risedronate)?
            Worth itNot sureNot worth it
            More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Reclast (zoledronate)?
            Worth itNot sureNot worth it