Compare Actos vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actos
(Pioglitazone)

Glucovance
(Metformin / Glyburide)

Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.121387283236994Actos
Reviews for Actos (Pioglitazone)
42%
of people say Actos (Pioglitazone) is worth it
31%
say it works well
21%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
ActosGlucovance
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Sore throat 4%
  • Cardiac failure 2%
  • Muscle pain 2%
  • Headache 2%
  • Back pain 1%
  • Sinus inflammation 1%
More Actos side effects »
  • Low blood sugar 35%
  • Gi side effects 14%
  • Diarrhea 11%
  • Abdominal pain 3%
  • Upper respiratory infection 3%
  • Nausea/vomiting 2%
  • Dizziness 2%
More Glucovance side effects »
How it works
ActosGlucovance
Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.
Type of medication
ActosGlucovance
Anti-diabetic
Thiazoladinedione
Prescription only
Anti-diabetic
Biguanide
Sulfonylurea
Prescription only
Available as
ActosGlucovance
  • Pill
  • Pill
Used for (click to learn more)
ActosGlucovance
Risk factors for serious side effects
ActosGlucovance
  • Heart failure diagnosis
    • Current liver problems
      • Female
      Detailed Actos (Pioglitazone) risks & warnings »
      • Kidney problems
      • Liver problems
      • Congestive heart failure
      • Using contrast dye for procedures
      • Surgery
      • Alcohol use
        • Elderly
        • Use of other blood sugar lowering medicines
        • Alcohol use
        • Intense physical activity
        • History of sulfa reactions
          Detailed Glucovance (Metformin / Glyburide) risks & warnings »
          Pregnancy category
          ActosGlucovance
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.
          • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
          • Try limiting the amount of alcohol you drink while taking this medication.
          Food
          No specific food-related info.
          • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
          • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
          • Can cause weight gain, headache, and fluid retention.
          • Actos (Pioglitazone) can cause too much fluid buildup in your body, which can cause or worsen congestive heart failure. Your doctor should follow your blood tests and weight closely when you start Actos (Pioglitazone) or increase your dose. People with heart failure classification NYHA Class III/IV shouldn't use Actos (Pioglitazone).
          • Actos (Pioglitazone) may increase fluid buildup in your body, called edema. The risk increases with a higher dose. Tell your doctor about any unexpected weight gain, swelling of extremities, or trouble breathing.
          • Can cause some weight gain.
          Upsides and benefits
          ActosGlucovance
          • Oral blood sugar-lowering medicine.
          • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          • Rarely causes low blood sugar.
          • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
          • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
          • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
          • Also lowers certain lipid (fat and cholesterol) levels.
          Downsides and risks
          ActosGlucovance
          • May take several weeks to lower blood sugar.
          • You have to check your blood sugar regularly with this medicine.
          • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
          • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
          • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
          • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
          • Slightly raises the risk of bladder cancer.
          • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
          • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
          • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
          • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
          • Can cause some weight gain.
          Tips from our pharmacists for people taking the medication
          ActosGlucovance
          • Takes several weeks to see full effect on blood sugar control.
          • Can cause weight gain, headache, and fluid retention.
          • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
          • Not recommended for patients with certain heart problems.
          • Check your blood sugar regularly.
          • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
          • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
          • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
          • Try limiting the amount of alcohol you drink while taking this medication.
          • Check your blood sugar regularly.
          Learn more
          More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
          More about GlucovanceSide effectsAlternativesFDA package insert