Compare Actos vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actos
(pioglitazone)

Diabeta
(glyburide)

Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
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Coupons for Actos
Best available price for 30 (30mg) tablets of actos
Coupons for glyburide
Best available price for 60 (5mg) tablets of glyburide
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.11Actos
Reviews for Actos
42%
of people (All ages) say Actos is worth it
30%
say it works well
21%
say it's a big hassle
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
-3% worse vs. Actos
34%
-4% worse vs. Actos
21%
Same vs. Actos
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
Actosglyburide
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
Actosglyburide
Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
Actosglyburide
Prescription onlyPrescription only
Available as
Actosglyburide
  • Pill
  • Pill
Used for
Actosglyburide
Risk factors for serious side effects
Actosglyburide
  • Heart failure diagnosis
  • Current liver problems
  • Female
Detailed Actos (pioglitazone) risks & warnings »
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Actosglyburide
No alcohol related info.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Food
Actosglyburide
No food related info.
  • Eat well-balanced meals to avoid low blood sugar.
Kidneys and liver
Actosglyburide
No kidneys and liver related info.
  • Not ideal for elderly or those with poor kidney function.
Weight
Actosglyburide
  • Can cause weight gain, headache, and fluid retention.
  • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
Upsides and benefits
Actosglyburide
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Rarely causes low blood sugar.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides and risks
Actosglyburide
  • May take several weeks to lower blood sugar.
  • You have to check your blood sugar regularly with this medicine.
  • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
  • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
  • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
  • Slightly raises the risk of bladder cancer.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Tips from our pharmacists for people taking the medication
Actosglyburide
  • Takes several weeks to see full effect on blood sugar control.
  • Can cause weight gain, headache, and fluid retention.
  • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
  • Not recommended for patients with certain heart problems.
  • Check your blood sugar regularly.
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Learn more
More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it