Compare Actos vs. Glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actos
(pioglitazone)

Diabeta
(glyburide)

Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).
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Coupons for
Prices and coupon for 30 (30mg) tablets of pioglitazone
Coupons for
Prices and coupon for 60 (5mg) tablets of glyburide
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.11Actos
Reviews for Actos (pioglitazone)
42%
of people (All ages) say Actos (pioglitazone) is worth it
30%
say it works well
21%
say it's a big hassle
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Reviews for Diabeta (glyburide)
45%
+3% better vs. Actos (pioglitazone)
34%
+4% better vs. Actos (pioglitazone)
21%
Same vs. Actos (pioglitazone)
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
ActosGlyburide
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
  • Gastrointestinal disturbances 2%
  • Allergic skin reactions 2%
More Glyburide side effects »
How it works
ActosGlyburide
Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
ActosGlyburide
Prescription only
Prescription only
Available as
ActosGlyburide
  • Pill
  • Pill
Used for
ActosGlyburide
Risk factors for serious side effects
ActosGlyburide
  • Heart failure diagnosis
    • Current liver problems
      • Female
      Detailed Actos (pioglitazone) risks & warnings »
        • Elderly
        • Use of other blood sugar lowering medicines
        • Alcohol
        • Intense physical activity
        • History of sulfa allergies
        Detailed Diabeta (glyburide) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        ActosGlyburide
        No alcohol related info.
        • Avoid drinking alcohol.
        Food
        ActosGlyburide
        No food related info.
        • Eat regular, balanced meals to avoid low blood sugar.
        Kidneys and liver
        ActosGlyburide
        No kidneys and liver related info.
        • Not a good choice for people with kidney problems because it's processed by the kidneys.
        Weight
        ActosGlyburide
        • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
        • Can cause weight gain, headache, and fluid retention.
        • Can cause mild weight gain (2 to 3 pounds).
        • Can cause weight gain, dizziness, or stomach upset.
        Upsides and benefits
        ActosGlyburide
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Rarely causes low blood sugar.
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • One of the least expensive diabetes medicines.
        Downsides and risks
        ActosGlyburide
        • May take several weeks to lower blood sugar.
        • You have to check your blood sugar regularly with this medicine.
        • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
        • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
        • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
        • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
        • Slightly raises the risk of bladder cancer.
        • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
        • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
        • Can cause mild weight gain (2 to 3 pounds).
        • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
        • Not a good choice for people with kidney problems because it's processed by the kidneys.
        • Loses effectiveness over time or as your body stops making insulin.
        Tips from our pharmacists for people taking the medication
        ActosGlyburide
        • Takes several weeks to see full effect on blood sugar control.
        • Can cause weight gain, headache, and fluid retention.
        • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
        • Not recommended for patients with certain heart problems.
        • Check your blood sugar regularly.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Can cause weight gain, dizziness, or stomach upset.
        • Avoid drinking alcohol.
        • Eat regular, balanced meals to avoid low blood sugar.
        • Check your blood sugar regularly.
        Learn more
        More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Actos (pioglitazone)?
        Worth itNot sureNot worth it
        More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Diabeta (glyburide)?
        Worth itNot sureNot worth it