Compare Actos vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actos (pioglitazone)

Prescription only
Lowers blood sugar.

Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.

4.1/ 7 average rating with 175 reviewsforActos
Lowers your blood sugar.

Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.

4.5/ 7 average rating with 79 reviewsforJanumet
Upsides
  • Improves sugar control and lowers A1c levels by around 1%.
  • Easily taken by mouth as a once a day pill.
  • Prevents the harmful effects of high sugar levels on your organs.
  • Rarely causes low blood sugar.
  • Lower the risk of heart attack or stroke.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides
  • May take several weeks to lower blood sugar.
  • Can cause weight gain.
  • People with heart failure or history of bladder cancer shouldn't use this medicine.
  • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
Lowest price near you
$12.05
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Lowest price near you
$415.3
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Reviews
175 
42%
think this treatment is worth it
30%
think this treatment works well
21%
think this treatment is a hassle

Have you used Actos (pioglitazone)?

Leave a review
79 
46%
think this treatment is worth it
38%
think this treatment works well
15%
think this treatment is a hassle

Have you used Janumet (sitagliptin / metformin)?

Leave a review
Side effects
10possible side effects
  • Low blood sugar
    27%
  • Swelling
    27%
  • Colds and flu
    13%
  • Headache
    9%
  • Heart failure
    8%
  • Sinus infection
    6%
  • Back pain
    6%
  • Pain in arms and legs
    6%
  • Muscle pain
    5%
  • Sore throat
    5%
See more detailed side effects
The Janumet (sitagliptin / metformin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Heart failure

    Heart failure

  • Liver damage

    Current liver problems

  • Bladder cancer

    History of bladder cancer

  • Bone fracture

    Women

See more detailed risks and warnings
  • Excess lactic acid in the blood

    Kidney problems

    ...and 5 more risk factors

See more detailed risks and warnings