Compare Actos vs. Metaglip

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actos
(pioglitazone)

Metaglip
(metformin / glipizide)

Lowers blood sugar. Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.Coming soon.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.11Actos
Reviews for Actos
42%
of people (All ages) say Actos is worth it
30%
say it works well
21%
say it's a big hassle
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it

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Have you used Metaglip (metformin / glipizide)?
Worth itNot sureNot worth it
Side effects
ActosMetaglip
  • Swelling 11%
  • Low blood sugar 8%
  • Colds and flu 4%
  • Headache 2%
  • Heart failure 2%
  • Sinus infection 1%
  • Back pain 1%
  • Muscle pain 2%
More Actos side effects »

We haven’t found good data for Metaglip side effects.

FDA side effect reports for Metaglip »
How it works
ActosMetaglip
Actos (pioglitazone) is a thiazolidinedione that improves your body's ability to use insulin to lower your blood sugar.Coming soon.
Type of medication
ActosMetaglip
Prescription only
Available as
ActosMetaglip
  • Pill
  • Pill
Used for
ActosMetaglip
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
ActosMetaglip
  • Heart failure
  • Current liver problems
  • History of bladder cancer
  • Women
Detailed Actos (pioglitazone) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    ActosMetaglip
    • Take once a day with or without food.
    No food related info.
    Kidneys and liver
    ActosMetaglip
    • If you've had liver problems or damage in the past, talk to your doctor before starting Actos (pioglitazone), since there's a small chance that it can hurt your liver. Tell your doctor about any stomach pain that don't go away, dark urine, or yellowing of eyes/skin. Your doctor will check your liver regularly.
    No kidneys and liver related info.
    Weight
    ActosMetaglip
    • Can cause weight gain, headache, and swelling from fluid build-up.
    • Can cause weight gain.
    No weight related info.
    Upsides and benefits
    ActosMetaglip
    • Improves sugar control and lowers A1c levels by around 1%.
    • Easily taken by mouth as a once a day pill.
    • Prevents the harmful effects of high sugar levels on your organs.
    • Rarely causes low blood sugar.
    • Lower the risk of heart attack or stroke.
    Coming soon
    Downsides and risks
    ActosMetaglip
    • May take several weeks to lower blood sugar.
    • Can cause weight gain.
    • People with heart failure or history of bladder cancer shouldn't use this medicine.
    • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
    • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
    Coming soon
    Tips from our pharmacists for people taking the medication
    ActosMetaglip
    • Take once a day with or without food.
    • May need several weeks to see full effect on blood sugar control.
    • Can cause weight gain, headache, and swelling from fluid build-up.
    • Tell your doctor about any shortness of breath, heart troubles, or unusual swelling.
    • Not recommended for patients with a history of heart failure or bladder cancer.
    • Check your blood sugar regularly.
    Coming soon
    Learn more
    More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Actos (pioglitazone)?
    Worth itNot sureNot worth it
    More about MetaglipSide effectsFDA package insert
    Have you used Metaglip (metformin / glipizide)?
    Worth itNot sureNot worth it