Compare Actos vs. Metaglip

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actos
(Pioglitazone)

Metaglip
(Metformin / Glipizide)

Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.Coming soon.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.11Actos
Reviews for Actos (Pioglitazone)
42%
of people (All ages) say Actos (Pioglitazone) is worth it
30%
say it works well
21%
say it's a big hassle
175 reviews
Have you used Actos (Pioglitazone)?
Worth itNot sureNot worth it

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Have you used Metaglip (Metformin / Glipizide)?
Worth itNot sureNot worth it
Side effects
ActosMetaglip
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »

We haven’t found good data for Metaglip side effects.

FDA side effect reports for Metaglip »
How it works
ActosMetaglip
Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Coming soon.
Type of medication
ActosMetaglip
Prescription only
Available as
ActosMetaglip
  • Pill
  • Pill
Used for
ActosMetaglip
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
ActosMetaglip
  • Heart failure diagnosis
    • Current liver problems
      • Female
      Detailed Actos (Pioglitazone) risks & warnings »
      Coming soon.
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Weight
      ActosMetaglip
      • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
      • Can cause weight gain, headache, and fluid retention.
      No weight related info.
      Upsides and benefits
      ActosMetaglip
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Rarely causes low blood sugar.
      Coming soon
      Downsides and risks
      ActosMetaglip
      • May take several weeks to lower blood sugar.
      • You have to check your blood sugar regularly with this medicine.
      • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
      • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
      • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
      • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
      • Slightly raises the risk of bladder cancer.
      Coming soon
      Tips from our pharmacists for people taking the medication
      ActosMetaglip
      • Takes several weeks to see full effect on blood sugar control.
      • Can cause weight gain, headache, and fluid retention.
      • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
      • Not recommended for patients with certain heart problems.
      • Check your blood sugar regularly.
      Coming soon
      Learn more
      More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Actos (Pioglitazone)?
      Worth itNot sureNot worth it
      More about MetaglipSide effectsFDA package insert
      Have you used Metaglip (Metformin / Glipizide)?
      Worth itNot sureNot worth it