Compare Actos vs. Prandin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Actos
(pioglitazone)

Prandin
(repaglinide)

Lowers blood sugar. Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.Lowers blood sugar. Prandin (repaglinide) works quickly to lower blood sugar, especially during mealtimes. However, it can cause hypoglycemia (low blood sugar) if you are not consistent with your diet and exercise schedule.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.11Actos
Reviews for Actos
42%
of people (All ages) say Actos is worth it
30%
say it works well
21%
say it's a big hassle
175 reviews
Have you used Actos (pioglitazone)?
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Have you used Prandin (repaglinide)?
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Side effects
ActosPrandin
  • Swelling 11%
  • Low blood sugar 8%
  • Colds and flu 4%
  • Headache 2%
  • Heart failure 2%
  • Sinus infection 1%
  • Back pain 1%
  • Muscle pain 2%
More Actos side effects »
  • Common cold 8%
  • Low blood sugar 24%
  • Headache 1%
  • Joint pain 3%
  • Sinusitis 4%
  • Diarrhea 3%
  • Back pain 1%
  • Swelling in arms and legs 5%
  • Heart failure 4%
More Prandin side effects »
How it works
ActosPrandin
Actos (pioglitazone) is a thiazolidinedione that improves your body's ability to use insulin to lower your blood sugar.Prandin (repaglinide) stimulates your body to produce more insulin.
Type of medication
ActosPrandin
Prescription onlyPrescription only
Available as
ActosPrandin
  • Pill
  • Pill
Used for
ActosPrandin
Risk factors for serious side effects
ActosPrandin
  • Heart failure
  • Current liver problems
  • History of bladder cancer
  • Women
Detailed Actos (pioglitazone) risks & warnings »
  • Alcoholism
  • Changes in meal pattern
  • Changes in exercise
  • Insulin
  • Other antidiabetic medications
Detailed Prandin (repaglinide) risks & warnings »
Pregnancy
Food
ActosPrandin
  • Take once a day with or without food.
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Quickly and effectively lowers blood sugar during meal times.
Kidneys and liver
ActosPrandin
  • If you've had liver problems or damage in the past, talk to your doctor before starting Actos (pioglitazone), since there's a small chance that it can hurt your liver. Tell your doctor about any stomach pain that don't go away, dark urine, or yellowing of eyes/skin. Your doctor will check your liver regularly.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
Weight
ActosPrandin
  • Can cause weight gain, headache, and swelling from fluid build-up.
  • Can cause weight gain.
  • May cause some weight gain.
Upsides and benefits
ActosPrandin
  • Improves sugar control and lowers A1c levels by around 1%.
  • Easily taken by mouth as a once a day pill.
  • Prevents the harmful effects of high sugar levels on your organs.
  • Rarely causes low blood sugar.
  • Lower the risk of heart attack or stroke.
  • Quickly and effectively lowers blood sugar during meal times.
  • Less likely to cause hypoglycemia (low blood sugar) than Starlix (nateglinide).
  • Good first-choice if you cannot tolerate metformin or add-on therapy if your blood sugars are not controlled on metformin alone.
Downsides and risks
ActosPrandin
  • May take several weeks to lower blood sugar.
  • Can cause weight gain.
  • People with heart failure or history of bladder cancer shouldn't use this medicine.
  • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
  • May cause some weight gain.
  • May cause hypoglycemia (low blood sugar).
  • Can frequently interfere with how other medicines work.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
Tips from our pharmacists for people taking the medication
ActosPrandin
  • Take once a day with or without food.
  • May need several weeks to see full effect on blood sugar control.
  • Can cause weight gain, headache, and swelling from fluid build-up.
  • Tell your doctor about any shortness of breath, heart troubles, or unusual swelling.
  • Not recommended for patients with a history of heart failure or bladder cancer.
  • Check your blood sugar regularly.
  • Works quickly to lower blood sugar so should be taken 15 to 30 minutes before a meal.
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Maintain a regular diet and exercise schedule while on this medicine to prevent fluctuations in your blood sugar.
Learn more
More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
More about PrandinSide effectsAlternativesFDA package insert
Have you used Prandin (repaglinide)?
Worth itNot sureNot worth it