Compare Adderall vs. Intuniv

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Adderall
(dextroamphetamine / amphetamine)

Intuniv
(guanfacine er)

Helps you focus and stay alert. Adderall (dextroamphetamine / amphetamine) is a first-choice treatment for ADHD that's available as a generic, but it's a stimulant, so it can cause difficulty sleeping and other side effects.Helps you focus your thoughts. Intuniv (guanfacine ER) is an option for ADHD patients who cannot take stimulants.
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Coupons for Adderall
Best available price for 60 (20mg) tablets of adderall
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.34Adderall
Reviews for Adderall
74%
of people (All ages) say Adderall is worth it
53%
say it works well
16%
say it's a big hassle
1309 reviews
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Have you used Intuniv (guanfacine er)?
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Side effects
AdderallIntuniv
  • Loss of appetite 34%
  • Dry mouth 30%
  • Sleep difficulty 14%
  • Headache 13%
  • Difficulty sleeping 15%
  • Stomach pain 4%
More Adderall side effects »
  • Headache 9%
  • Fatigue 10%
  • Dizziness 6%
  • Loss of appetite 1%
  • Stomach pain 4%
  • Irritability 3%
  • Anxiety 2%
  • Rash 2%
  • Constipation 3%
  • Weight gain 1%
More Intuniv side effects »
How it works
AdderallIntuniv
Adderall (dextroamphetamine / amphetamine) is an amphetamine stimulant. Researchers don't know exactly how it works for ADHD, but it increases the activity of the hormones norepinephrine and dopamine in the brain, which affects attention and behavior.While it's not clear how Intuniv (guanfacine ER) works against ADHD, it works in the brain to relax blood vessels and slow down heart rate.
Type of medication
AdderallIntuniv
Prescription onlyPrescription only
Available as
AdderallIntuniv
  • Pill
  • Extended release
Used for
AdderallIntuniv
Risk factors for serious side effects
AdderallIntuniv
  • History of heart problems
  • Misuse of Adderall (dextroamphetamine / amphetamine)
  • History of drug abuse
  • Taking more than the prescribed dose
  • History of high blood pressure
Detailed Adderall (dextroamphetamine / amphetamine) risks & warnings »
  • High blood pressure
  • Heartrate problems
  • Stopping Intuniv (guanfacine ER) suddenly.
  • History of heart problem
Detailed Intuniv (guanfacine er) risks & warnings »
Pregnancy
Alcohol
AdderallIntuniv
  • Don't take it with alcohol or illicit drugs.
No alcohol related info.
Food
AdderallIntuniv
No food related info.
  • Avoid taking Intuniv (guanfacine ER) with a high-fat meal.
Sleep
AdderallIntuniv
No sleep related info.
  • May cause drowsiness, dizziness, and headaches especially at higher doses.
  • It may cause drowsiness, especially when you first start taking Intuniv (guanfacine ER) or with dose increases, so do not drive until you know how Intuniv (guanfacine ER) affects you.
Weight
AdderallIntuniv
  • Can cause blurry vision, loss of appetite, weight loss, headache, dry mouth, or anxious feelings.
No weight related info.
Upsides and benefits
AdderallIntuniv
  • First-choice medication to treat ADHD.
  • Adderall (dextroamphetamine / amphetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • Available as a generic medication.
  • Available in both immediate and extended release forms.
  • For the extended release capsule, if you can't swallow the whole capsule, the capsule can be opened, mixed in a spoonful of applesauce, and swallowed.
  • Not a stimulant and is an option for people who cannot take stimulants.
  • Can be used either alone or with other stimulant medications.
  • Available in generic.
Downsides and risks
AdderallIntuniv
  • Has to be taken in the morning and early afternoon, otherwise it can cause difficulty sleeping.
  • It's a controlled medication and should be locked up to prevent potential abuse.
  • Not safe for people with a history of heart problems.
  • For school-aged children, a second dose will likely need to be given at school.
  • Intuniv (guanfacine ER) can cause changes in your blood pressure so it will be important to watch your blood pressure regularly.
  • May cause drowsiness, dizziness, and headaches especially at higher doses.
  • It can make you feel more irritable or anxious. Talk to your doctor if it bothers you.
  • Not recommended for people over 65 years old.
  • It may cause drowsiness, especially when you first start taking Intuniv (guanfacine ER) or with dose increases, so do not drive until you know how Intuniv (guanfacine ER) affects you.
Tips from our pharmacists for people taking the medication
AdderallIntuniv
  • Can cause blurry vision, loss of appetite, weight loss, headache, dry mouth, or anxious feelings.
  • Don't take it with alcohol or illicit drugs.
  • Can cause trouble sleeping, so don't take it close to bedtime.
  • If using the extended-release version, the first dose is best taken right after waking up in the morning.
  • Capsules can be opened and sprinkled on applesauce, which should be consumed immediately, and swallowed without chewing.
  • Do not crush or cut these tablets.
  • Intuniv (guanfacine ER) can be taken day or night. You can take Intuniv (guanfacine ER) at night if it makes you sleepy.
  • Avoid taking Intuniv (guanfacine ER) with a high-fat meal.
  • Intuniv (guanfacine ER) can lower your blood pressure so check your blood pressure regularly, especially when first starting Intuniv (guanfacine ER), or if your dose changes.
  • Do not stop Intuniv (guanfacine ER) suddenly because it can quickly increase your blood pressure.
  • The extended release form of Intuniv (guanfacine ER) is used for ADHD. The immediate release form is used to lower your blood pressure.
Learn more
More about AdderallSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Adderall (dextroamphetamine / amphetamine)?
Worth itNot sureNot worth it
More about IntunivSide effectsAlternativesFDA package insert
Have you used Intuniv (guanfacine er)?
Worth itNot sureNot worth it