Compare Adderall vs. Vyvanse

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Helps you focus and stay alert.

Adderall (dextroamphetamine / amphetamine) is a first-choice treatment for ADHD that's available as a generic, but it's a stimulant that can cause difficulty sleeping and other side effects.

3.9/ 5 average rating with 1309 reviewsforAdderall
Helps you focus and stay alert.

Vyvanse (lisdexamfetamine) is a first-choice treatment for attention-deficit/hyperactivity disorder, but it can be expensive since it's only available as a brand name product.

3.7/ 5 average rating with 491 reviewsforVyvanse
Upsides
  • First-choice medication to treat ADHD.
  • Adderall (dextroamphetamine / amphetamine) is used together with counseling or other non-drug therapies to treat ADHD.
  • Available as an affordable generic medication.
  • Available in both immediate and extended release forms.
  • For the extended release capsule, if you can't swallow the whole capsule, the capsule can be opened, mixed in a spoonful of applesauce, and swallowed.
  • Vyvanse (lisdexamfetamine) is a first-choice medication to treat attention-deficit/hyperactivity disorder (ADHD).
  • It is usually dosed once a day, so parents don't need to send the medication with their children to school.
  • Can take the capsule as a whole or mix the contents with water, orange juice, or yogurt.
  • Available as a chewable pill form.
Downsides
  • Must take in the morning and early afternoon, otherwise it can cause difficulty sleeping.
  • It's a controlled medication and should be locked up to prevent potential abuse.
  • Not safe for people with a history of heart problems.
  • For school-aged children, a second dose will likely need to be given at school.
  • Need to take Vyvanse (lisdexamfetamine) in the morning, otherwise it can cause difficulty sleeping at night.
  • Vyvanse (lisdexamfetamine) is not available as a generic medication, so it is expensive.
  • This medicine has the potential for abuse and dependence.
  • Can cause serious side effects for the heart.
  • Can also slow growth in children and cause weight loss.
Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
1309 reviews so far
74%
saidit'sworth it
53%
saiditworked well
16%
saidit'sa big hassle

Have you used Adderall (dextroamphetamine / amphetamine)?

Leave a review
491 reviews so far
67%
saidit'sworth it
49%
saiditworked well
17%
saidit'sa big hassle

Have you used Vyvanse (lisdexamfetamine)?

Leave a review
Side effects
The Adderall (dextroamphetamine / amphetamine) FDA package insert doesn’t have numbers about how common side effects are.
15possible side effects
  • Decreased appetite
    27%
  • Difficulty sleeping
    27%
  • Dry mouth
    26%
  • Diarrhea
    7%
  • Nausea
    7%
  • Anxiety
    6%
  • Loss of appetite
    5%
  • Feeling jittery
    4%
  • Agitation
    3%
  • Increased blood pressure
    3%
  • Sweating
    3%
  • Restlessness
    3%
  • Difficulty breathing
    2%
  • Increased heart rate
    2%
  • Tremor
    2%
See more detailed side effects
Risks and risk factors
  • Serious or life-threatening cardiovascular events
    • History of heart problems
    • Misuse of Adderall (dextroamphetamine / amphetamine)
  • Dependence and abuse
    • History of drug abuse
    • Misuse of Adderall (dextroamphetamine / amphetamine)
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels
  • Aggressive behavior and psychosis
    • History of psychotic episodes
    • History of bipolar disorder
  • Driving impairment
    • Taking Adderall (dextroamphetamine / amphetamine) with alcohol
    • Taking other medicines that cause dizziness and/or drowsiness
  • Long-term growth suppression
    • Children ages 7 to 10
See more detailed risks and warnings
  • High blood pressure
    • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting Vyvanse (lisdexamfetamine)
  • Abuse and dependence
    • History of drug abuse
  • Serious or life-threatening cardiovascular events
    • History of heart problems
  • Aggressive behavior and psychosis
    • History of psychotic episodes
    • History of bipolar disorder
  • Long-term growth suppression
    • Children ages 6 to 12
See more detailed risks and warnings