Compare Advair vs. Combivent

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advair Diskus
(Fluticasone / Salmeterol)

Combivent
(Ipratropium / Albuterol)

Prevents breathing problems. Advair Diskus (Fluticasone / Salmeterol) is good for people who need two medicines to control their asthma or COPD, but it might be expensive since there's no generic available.Makes it easier to breathe. Combivent (Ipratropium / Albuterol) is good for people who need 2 medicines to relieve their COPD symptoms, but you need to be okay with taking it four times a day.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.15Advair
Reviews for Advair
66%
of people (All ages) say Advair is worth it
48%
say it works well
11%
say it's a big hassle
799 reviews
Have you used Advair Diskus (Fluticasone / Salmeterol)?
Worth itNot sureNot worth it
Reviews for Combivent
63%
+3% better vs. Advair
37%
+11% better vs. Advair
13%
+2% better vs. Advair
142 reviews
Have you used Combivent (Ipratropium / Albuterol)?
Worth itNot sureNot worth it
Side effects
AdvairCombivent
  • Pneumonia 6%
  • Muscle cramps and spasms 2%
  • Dizziness 2%
  • Fever 1%
  • Hoarseness/dysphonia 5%
  • Viral respiratory infections 3%
  • Throat irritation 1%
More Advair side effects »
  • Nausea 2%
  • Pharyngitis 2%
  • Sinusitis 2%
  • Pain 3%
  • Respiratory Disorders 3%
  • Coughing 4%
  • Dyspnea 5%
  • Headache 6%
  • Upper Respiratory Tract Infection 11%
  • Bronchitis 12%
More Combivent side effects »
How it works
AdvairCombivent
Advair Diskus (Fluticasone / Salmeterol) is a combination medicine. Fluticasone (a corticosteroid) lowers lung inflammation to control asthma and COPD. Salmeterol (a bronchodilator) relaxes muscles in your lungs to open airways and make breathing easier.Combivent (Ipratropium / Albuterol) is a combination medicine. It contains two bronchodilators (ipratropium and albuterol), which relax muscles in your lungs to open airways and make breathing easier.
Type of medication
AdvairCombivent
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
AdvairCombivent
  • Inhaler
  • Inhaler
Used for
AdvairCombivent
Risk factors for serious side effects
AdvairCombivent
  • Adverse effect of long-acting beta agonist drugs (LABAs), one of the medications in Advair Diskus (Fluticasone / Salmeterol), a combination drug.
  • History of chronic obstructive pulmonary disease (COPD)
  • COPD includes chronic bronchitis and emphysema
  • Age greater than 65 years
  • Lowering dose or stopping Advair Diskus (Fluticasone / Salmeterol) too quickly especially after long-term treatment
Detailed Advair Diskus (Fluticasone / Salmeterol) risks & warnings »
  • History of rapid heartbeat
  • History of high blood pressure
  • history of heart failure or chest pain.
  • History of narrow-angle glaucoma
  • History of high eye pressure
Detailed Combivent (Ipratropium / Albuterol) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
AdvairCombivent
  • Adrenal suppression can occur if you lower your dose or stop taking Advair Diskus (Fluticasone / Salmeterol) too quickly which is related to one of the medications in the combination. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your medication need to be done slowly and over time. Talk to your doctor before you decrease or stop Advair Diskus (Fluticasone / Salmeterol).
No kidneys and liver related info.
Weight
AdvairCombivent
  • Steroids can slow height growth in kids.
No weight related info.
Upsides and benefits
AdvairCombivent
  • 2-in-1 medicine that lowers inflammation and opens airways in your lungs. Medicines are more effective together than alone.
  • Makes lung function significantly better.
  • Lowers the number of flare-ups and rescue inhaler uses in asthma and COPD.
  • You only have to use it twice a day.
  • Both the Diskus and inhaler can be used to treat asthma.
  • 2-in-1 medicine that opens airways and makes it easier to breathe. Medicines are more effective together than alone.
  • Effectively relieves COPD and asthma symptoms.
  • Respimat formulation has a clear display for dosing, doesn't require shaking, and only needs one inhalation per dose.
Downsides and risks
AdvairCombivent
  • You have to use Advair every day to control your symptoms.
  • You can't lower the dose or stop taking it too suddenly.
  • The HFA inhaler isn't approved to treat COPD.
  • Can make your heart race.
  • Steroids can slow height growth in kids.
  • Because steroids suppress your immune system, you can catch bacterial and viral infections easier, and they can take longer to go away.
  • There have been some reports of worsening asthma leading to death when taking this medicine.
  • You have to use Combivent four times a day.
  • Can make your heart race.
  • Can make symptoms of enlarged prostate or urinary blockage worse.
  • Can worsen a certain type of glaucoma.
Tips from our pharmacists for people taking the medication
AdvairCombivent
  • Lowers inflammation and opens airways to improve breathing.
  • Starts working in about 30 minutes, but it can take 1 to 2 weeks to feel the full effects.
  • Prevents asthma symptoms, but doesn't treat sudden wheezing or asthma attacks once they start.
  • Use inhaler in a level position, and don't breathe out into the device.
  • Rinse your mouth out with water after each use.
  • Shake inhaler for 5 seconds before you use it.
  • Pump the inhaler 4 times before inhaling the first dose, or if it's been more than a month since your last dose.
  • Call 911 or your doctor if it's hard to breathe or you have an asthma attack while on this medication.
  • Diskus contains lactose, so don't use it if you're allergic to milk protein.
  • Starts working in 15 to 30 minutes, and lasts about 4 to 6 hours.
  • Make sure to read the instructions about how to set up your first dose.
  • Clean the mouthpiece with a damp cloth once a week.
  • The inhaler shows you how much medication you have left so you can plan ahead for refills.
  • Don't take it more often or change your dose without talking to your doctor first.
  • Tell your doctor if the medication stops working or if your symptoms get worse.
  • One type of inhaler contains soya lecithin, so don't use if you have soybean, peanut, or allergies to atropine.
Learn more
More about AdvairSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Advair Diskus (Fluticasone / Salmeterol)?
Worth itNot sureNot worth it
More about CombiventSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Combivent (Ipratropium / Albuterol)?
Worth itNot sureNot worth it