Compare Advair vs. Combivent

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advair Diskus
(Fluticasone / Salmeterol)

Combivent
(Ipratropium / Albuterol)

Prevents breathing problems. Advair Diskus (Fluticasone / Salmeterol) is good for people who need two medicines to control their asthma or COPD, but it might be expensive since there's no generic available.Makes it easier to breathe. Combivent (Ipratropium / Albuterol) is good for people who need 2 medicines to relieve their COPD symptoms, but you need to be okay with taking it four times a day.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.133248730964467Advair
Reviews for Advair Diskus (Fluticasone / Salmeterol)
66%
of people say Advair Diskus (Fluticasone / Salmeterol) is worth it
47%
say it works well
11%
say it's a big hassle
Reviews for Combivent (Ipratropium / Albuterol)
63%
3% vs. Advair Diskus (Fluticasone / Salmeterol)
37%
10% vs. Advair Diskus (Fluticasone / Salmeterol)
13%
2% vs. Advair Diskus (Fluticasone / Salmeterol)
Side effects
AdvairCombivent
  • Ear, nose, or throat infection 13%
  • Candidiasis mouth/throat 9%
  • Lung infection 8%
  • Sore throat 7%
  • Bronchitis 6%
  • Nausea and vomiting 5%
  • Headaches 4%
  • Cough 4%
  • Diarrhea 3%
  • Viral respiratory infections 3%
More Advair side effects »

The Combivent FDA package insert doesn’t have numbers about how common side effects are.

More about Combivent side effects »
How it works
AdvairCombivent
Advair Diskus (Fluticasone / Salmeterol) is a combination medicine. Fluticasone (a corticosteroid) lowers lung inflammation to control asthma and COPD. Salmeterol (a bronchodilator) relaxes muscles in your lungs to open airways and make breathing easier.Combivent (Ipratropium / Albuterol) is a combination medicine. It contains two bronchodilators (ipratropium and albuterol), which relax muscles in your lungs to open airways and make breathing easier.
Type of medication
AdvairCombivent
Anti-inflammatory
Corticosteroid
Bronchodilator
Long-acting bronchodilator
Prescription only
Bronchodilator
Short-acting bronchodilator
Bronchodilator
Short-acting bronchodilator
Prescription only
Available as
AdvairCombivent
  • Inhaler
  • Inhaler
Used for (click to learn more)
AdvairCombivent
Risk factors for serious side effects
AdvairCombivent
  • Adverse effect of long-acting beta agonist drugs (LABAs), one of the medications in Advair Diskus (Fluticasone / Salmeterol), a combination drug.
  • History of chronic obstructive pulmonary disease (COPD)
  • COPD includes chronic bronchitis and emphysema
  • Age greater than 65 years
  • Lowering dose or stopping Advair Diskus (Fluticasone / Salmeterol) too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Not rinsing mouth after use
  • Higher dose of the corticosteroid medication contained in Advair Diskus (Fluticasone / Salmeterol)
  • Adverse effect of long-acting beta agonist drugs (LABAs), one of the medications in Advair Diskus (Fluticasone / Salmeterol), a combination drug.
  • History of arrhythmia, hypertension or heart failure
  • Severe milk protein allergy
Detailed Advair Diskus (Fluticasone / Salmeterol) risks & warnings »
    • History of rapid heartbeat
    • History of high blood pressure
    • history of heart failure or chest pain.
    • History of narrow-angle glaucoma
    • History of high eye pressure
    • Spraying Combivent (Ipratropium / Albuterol) into eyes
    • History of urinary bladder blockage (urinary obstruction)
    • History of enlarged prostate
    • History of atropine allergic reaction
    • Taking Combivent (Ipratropium / Albuterol) with drugs that decrease potassium
    • History of low potassium
    • Taking Combivent (Ipratropium / Albuterol) aerosol inhaler
    • History of soybean allergy
    • History of peanut allergy
    Detailed Combivent (Ipratropium / Albuterol) risks & warnings »
    Pregnancy category
    AdvairCombivent
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • There are reports of severe allergic reactions in people taking Combivent (Ipratropium / Albuterol) aerosol inhaler who have allergies to soybean or peanuts. This is because the aerosol contains soya lecithin. Call 911 or your doctor right away if you develop severe rash, itching, swelling or difficulty breathing while taking Combivent (Ipratropium / Albuterol). Talk to your doctor about other medication choices to treat your COPD if you know you have food allergies to soybean and/or peanuts.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    • Advair Diskus (Fluticasone / Salmeterol) may increase blood pressure and heart rate, especially if you already have these conditions. These symptoms are related to one of the medications in this product so don't change or increase your dose without talking to your doctor first. Tell your doctor if you develop dizziness, tremor, nausea, rapid heartbeat, become very tired or have difficulty sleeping while taking Advair Diskus (Fluticasone / Salmeterol), you may need to change or stop this medication.
    • One of the medications in Combivent (Ipratropium / Albuterol) may increase blood pressure and heart rate, especially if you already have these conditions. Tell your doctor if you notice a tremor, rapid heartbeat, get dizzy or have difficulty sleeping while taking Combivent (Ipratropium / Albuterol), you may need to change or stop this medication.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    AdvairCombivent
    • 2-in-1 medicine that lowers inflammation and opens airways in your lungs. Medicines are more effective together than alone.
    • Makes lung function significantly better.
    • Lowers the number of flare-ups and rescue inhaler uses in asthma and COPD.
    • You only have to use it twice a day.
    • Both the Diskus and inhaler can be used to treat asthma.
    • 2-in-1 medicine that opens airways and makes it easier to breathe. Medicines are more effective together than alone.
    • Effectively relieves COPD and asthma symptoms.
    • Respimat formulation has a clear display for dosing, doesn't require shaking, and only needs one inhalation per dose.
    Downsides and risks
    AdvairCombivent
    • You have to use Advair every day to control your symptoms.
    • You can't lower the dose or stop taking it too suddenly.
    • The HFA inhaler isn't approved to treat COPD.
    • Steroids can slow height growth in kids.
    • Because steroids suppress your immune system, you can catch bacterial and viral infections easier, and they can take longer to go away.
    • There have been some reports of worsening asthma leading to death when taking this medicine.
    • Can make your heart race.
    • You have to use Combivent four times a day.
    • Can make symptoms of enlarged prostate or urinary blockage worse.
    • Can worsen a certain type of glaucoma.
    • Can make your heart race.
    Tips from our pharmacists for people taking the medication
    AdvairCombivent
    • Lowers inflammation and opens airways to improve breathing.
    • Starts working in about 30 minutes, but it can take 1 to 2 weeks to feel the full effects.
    • Prevents asthma symptoms, but doesn't treat sudden wheezing or asthma attacks once they start.
    • Use inhaler in a level position, and don't breathe out into the device.
    • Rinse your mouth out with water after each use.
    • Shake inhaler for 5 seconds before you use it.
    • Pump the inhaler 4 times before inhaling the first dose, or if it's been more than a month since your last dose.
    • Call 911 or your doctor if it's hard to breathe or you have an asthma attack while on this medication.
    • Diskus contains lactose, so don't use it if you're allergic to milk protein.
    • Starts working in 15 to 30 minutes, and lasts about 4 to 6 hours.
    • Make sure to read the instructions about how to set up your first dose.
    • Clean the mouthpiece with a damp cloth once a week.
    • The inhaler shows you how much medication you have left so you can plan ahead for refills.
    • Don't take it more often or change your dose without talking to your doctor first.
    • Tell your doctor if the medication stops working or if your symptoms get worse.
    • One type of inhaler contains soya lecithin, so don't use if you have soybean, peanut, or allergies to atropine.
    Learn more
    More about AdvairSide effectsReviews & ratingsAlternativesFDA package insert
    More about CombiventSide effectsReviews & ratingsAlternativesFDA package insert