Compare Advair vs. Singulair

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advair Diskus
(Fluticasone / Salmeterol)

Singulair
(Montelukast)

Prevents breathing problems. Advair Diskus (Fluticasone / Salmeterol) is good for people who need two medicines to control their asthma or COPD, but it might be expensive since there's no generic available.Prevents breathing problems. Singulair (Montelukast) has fewer side effects but doesn't work as well as steroid inhalers for asthma. It also helps with allergies.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.133248730964467Advair
Reviews for Advair Diskus (Fluticasone / Salmeterol)
66%
of people (All ages) say Advair Diskus (Fluticasone / Salmeterol) is worth it
47%
say it works well
11%
say it's a big hassle
788 reviews
Have you used Advair Diskus (Fluticasone / Salmeterol)?
Worth itNot sureNot worth it
Reviews for Singulair (Montelukast)
66%
Same vs. Advair Diskus (Fluticasone / Salmeterol)
46%
1% vs. Advair Diskus (Fluticasone / Salmeterol)
13%
2% vs. Advair Diskus (Fluticasone / Salmeterol)
552 reviews
Have you used Singulair (Montelukast)?
Worth itNot sureNot worth it
Side effects
AdvairSingulair
  • Ear, nose, or throat infection 13%
  • Candidiasis mouth/throat 9%
  • Lung infection 8%
  • Sore throat 7%
  • Bronchitis 6%
  • Nausea and vomiting 5%
  • Headaches 4%
  • Cough 4%
  • Diarrhea 3%
  • Viral respiratory infections 3%
More Advair side effects »
  • Dizziness 1%
  • Muscle weakness/fatiguea/fatigue 1%
  • Decreased liver function 1%
  • Congestion, nasal 1%
  • Pain, dental 1%
More Singulair side effects »
How it works
AdvairSingulair
Advair Diskus (Fluticasone / Salmeterol) is a combination medicine. Fluticasone (a corticosteroid) lowers lung inflammation to control asthma and COPD. Salmeterol (a bronchodilator) relaxes muscles in your lungs to open airways and make breathing easier.Singulair (Montelukast) is a leukotriene inhibitor. It lowers inflammation in your lungs and nasal passages to prevent asthma and relieve allergies.
Type of medication
AdvairSingulair
Anti-inflammatory
Corticosteroid
Bronchodilator
Long-acting bronchodilator
Prescription only
Anti-inflammatory
Leukotriene modifier
Prescription only
Available as
AdvairSingulair
  • Inhaler
  • Pill
  • Chewable tablet
  • Granule
Used for (click to learn more)
AdvairSingulair
Risk factors for serious side effects
AdvairSingulair
  • Adverse effect of long-acting beta agonist drugs (LABAs), one of the medications in Advair Diskus (Fluticasone / Salmeterol), a combination drug.
  • History of chronic obstructive pulmonary disease (COPD)
  • COPD includes chronic bronchitis and emphysema
  • Age greater than 65 years
  • Lowering dose or stopping Advair Diskus (Fluticasone / Salmeterol) too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Not rinsing mouth after use
  • Higher dose of the corticosteroid medication contained in Advair Diskus (Fluticasone / Salmeterol)
  • Adverse effect of long-acting beta agonist drugs (LABAs), one of the medications in Advair Diskus (Fluticasone / Salmeterol), a combination drug.
  • History of arrhythmia, hypertension or heart failure
  • Severe milk protein allergy
Detailed Advair Diskus (Fluticasone / Salmeterol) risks & warnings »
  • Exercise-induced asthma
  • Other environmental triggers
    • Recent treatment with corticosteroid medication
    • Lowering dose of corticosteroid medication
    • History of phenylketonuria (PKU)
    • History of liver disease including hepatitis
    • history of alcohol use
    • Other medications that cause liver injury
    Detailed Singulair (Montelukast) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    AdvairSingulair
    No food related info.
    • Singulair (Montelukast) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
    Kidneys and liver
    AdvairSingulair
    • Adrenal suppression can occur if you lower your dose or stop taking Advair Diskus (Fluticasone / Salmeterol) too quickly which is related to one of the medications in the combination. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your medication need to be done slowly and over time. Talk to your doctor before you decrease or stop Advair Diskus (Fluticasone / Salmeterol).
    • There are reports of liver injury in people taking Singulair (Montelukast) mostly in combination with other factors such as drugs, alcohol, and liver disease. If you have any of these risk factors, your doctor will need to check your liver function periodically.
    Weight
    AdvairSingulair
    • Steroids can slow height growth in kids.
    No weight related info.
    Upsides and benefits
    AdvairSingulair
    • 2-in-1 medicine that lowers inflammation and opens airways in your lungs. Medicines are more effective together than alone.
    • Makes lung function significantly better.
    • Lowers the number of flare-ups and rescue inhaler uses in asthma and COPD.
    • You only have to use it twice a day.
    • Both the Diskus and inhaler can be used to treat asthma.
    • Prevents symptoms and improves lung function in children and adults with chronic asthma.
    • A single 10 mg dose improves exercise-induced asthma symptoms for up to 24 hours.
    • Fewer side effects compared to other asthma treatments.
    • Also relieves nasal allergy symptoms.
    • Effective pill alternative to corticosteroid inhalers.
    Downsides and risks
    AdvairSingulair
    • You have to use Advair every day to control your symptoms.
    • You can't lower the dose or stop taking it too suddenly.
    • The HFA inhaler isn't approved to treat COPD.
    • Can make your heart race.
    • Steroids can slow height growth in kids.
    • Because steroids suppress your immune system, you can catch bacterial and viral infections easier, and they can take longer to go away.
    • There have been some reports of worsening asthma leading to death when taking this medicine.
    • You have to use Montelukast every day to control your symptoms.
    • Somewhat less effective than corticosteroid inhalers for asthma.
    • There's no generic available, so it can be expensive.
    • Can cause behavior changes, agitation, aggression, and difficulty sleeping for some people.
    Tips from our pharmacists for people taking the medication
    AdvairSingulair
    • Lowers inflammation and opens airways to improve breathing.
    • Starts working in about 30 minutes, but it can take 1 to 2 weeks to feel the full effects.
    • Prevents asthma symptoms, but doesn't treat sudden wheezing or asthma attacks once they start.
    • Use inhaler in a level position, and don't breathe out into the device.
    • Rinse your mouth out with water after each use.
    • Shake inhaler for 5 seconds before you use it.
    • Pump the inhaler 4 times before inhaling the first dose, or if it's been more than a month since your last dose.
    • Call 911 or your doctor if it's hard to breathe or you have an asthma attack while on this medication.
    • Diskus contains lactose, so don't use it if you're allergic to milk protein.
    • Take it once a day to control asthma and allergy symptoms.
    • If you're using it for asthma or allergies, take it in the evening.
    • Use it 2 hours before exercising.
    • Granules can be taken by mouth or dissolved in liquid or soft food.
    • Doesn't treat sudden wheezing or asthma attacks once they start. Keep a fast-acting (rescue) inhaler with you.
    • The chewable tablets contain aspartame, so don't use them if you have a sensitivity to phenylalanine or phenylketones.
    Learn more
    More about AdvairSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Advair Diskus (Fluticasone / Salmeterol)?
    Worth itNot sureNot worth it
    More about SingulairSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Singulair (Montelukast)?
    Worth itNot sureNot worth it