Compare Advair vs. Spiriva

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advair Diskus
(Fluticasone / Salmeterol)

Spiriva
(Tiotropium)

Prevents breathing problems. Advair Diskus (Fluticasone / Salmeterol) is good for people who need two medicines to control their asthma or COPD, but it might be expensive since there's no generic available.Makes it easier to breathe. Spiriva (Tiotropium) works well to reduce COPD symptoms and flare-ups with fewer side effects than some medicines that open airways, but you have to use it every day.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.133248730964467Advair
Reviews for Advair Diskus (Fluticasone / Salmeterol)
66%
of people say Advair Diskus (Fluticasone / Salmeterol) is worth it
47%
say it works well
11%
say it's a big hassle
Reviews for Spiriva (Tiotropium)
62%
4% vs. Advair Diskus (Fluticasone / Salmeterol)
43%
4% vs. Advair Diskus (Fluticasone / Salmeterol)
9%
+2% vs. Advair Diskus (Fluticasone / Salmeterol)
Side effects
AdvairSpiriva
  • Ear, nose, or throat infection 13%
  • Candidiasis mouth/throat 9%
  • Lung infection 8%
  • Sore throat 7%
  • Bronchitis 6%
  • Nausea and vomiting 5%
  • Headaches 4%
  • Cough 4%
  • Diarrhea 3%
  • Viral respiratory infections 3%
More Advair side effects »
  • Dry mouth 13%
  • Respiratory tract infection 4%
  • Sore throat 2%
  • Sinus inflammation 2%
  • Urinary tract infection 2%
  • Chest pain (non-specific) 2%
  • Abdominal pain 2%
  • Yeast infection 2%
  • Rash 2%
  • Nosebleed 2%
More Spiriva side effects »
How it works
AdvairSpiriva
Advair Diskus (Fluticasone / Salmeterol) is a combination medicine. Fluticasone (a corticosteroid) lowers lung inflammation to control asthma and COPD. Salmeterol (a bronchodilator) relaxes muscles in your lungs to open airways and make breathing easier.Spiriva (Tiotropium) is a bronchodilator. It relaxes muscles in your lungs to open your airways and make breathing easier.
Type of medication
AdvairSpiriva
Anti-inflammatory
Corticosteroid
Bronchodilator
Long-acting bronchodilator
Prescription only
Bronchodilator
Long-acting bronchodilator
Prescription only
Available as
AdvairSpiriva
  • Inhaler
  • Inhaler
Used for (click to learn more)
AdvairSpiriva
Risk factors for serious side effects
AdvairSpiriva
  • Adverse effect of long-acting beta agonist drugs (LABAs), one of the medications in Advair Diskus (Fluticasone / Salmeterol), a combination drug.
  • History of chronic obstructive pulmonary disease (COPD)
  • COPD includes chronic bronchitis and emphysema
  • Age greater than 65 years
  • Lowering dose or stopping Advair Diskus (Fluticasone / Salmeterol) too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Not rinsing mouth after use
  • Higher dose of the corticosteroid medication contained in Advair Diskus (Fluticasone / Salmeterol)
  • Adverse effect of long-acting beta agonist drugs (LABAs), one of the medications in Advair Diskus (Fluticasone / Salmeterol), a combination drug.
  • History of arrhythmia, hypertension or heart failure
  • Severe milk protein allergy
Detailed Advair Diskus (Fluticasone / Salmeterol) risks & warnings »
  • History of atropine allergic reaction
    • History of narrow-angle glaucoma
    • History of urinary bladder blockage (urinary obstruction)
    • History of enlarged prostate
    • Severe milk protein allergy
    • History of moderate to severe kidney disease
    • Taking with other anticholinergic medications
    Detailed Spiriva (Tiotropium) risks & warnings »
    Pregnancy category
    AdvairSpiriva
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • The kidney is mainly responsible for removing Spiriva (Tiotropium) from the body so people with kidney disease or reduced function need to be watched closely. Spiriva (Tiotropium) can build up in the body and cause certain side effects. Tell your doctor if you develop dry mouth, blurry vision, confusion, sweating, increased heart rate or constipation. You may need to discuss other medication options to treat your COPD.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    • Advair Diskus (Fluticasone / Salmeterol) may increase blood pressure and heart rate, especially if you already have these conditions. These symptoms are related to one of the medications in this product so don't change or increase your dose without talking to your doctor first. Tell your doctor if you develop dizziness, tremor, nausea, rapid heartbeat, become very tired or have difficulty sleeping while taking Advair Diskus (Fluticasone / Salmeterol), you may need to change or stop this medication.
    No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    AdvairSpiriva
    • 2-in-1 medicine that lowers inflammation and opens airways in your lungs. Medicines are more effective together than alone.
    • Makes lung function significantly better.
    • Lowers the number of flare-ups and rescue inhaler uses in asthma and COPD.
    • You only have to use it twice a day.
    • Both the Diskus and inhaler can be used to treat asthma.
    • Helps you breathe easier and lessens the need for a fast-acting (rescue) inhaler.
    • Reduces flare-ups and hospitalizations with fewer side effects compared to some other medicines that open airways.
    • You only need to take it once a day.
    Downsides and risks
    AdvairSpiriva
    • You have to use Advair every day to control your symptoms.
    • You can't lower the dose or stop taking it too suddenly.
    • The HFA inhaler isn't approved to treat COPD.
    • Can make your heart race.
    • Steroids can slow height growth in kids.
    • Because steroids suppress your immune system, you can catch bacterial and viral infections easier, and they can take longer to go away.
    • There have been some reports of worsening asthma leading to death when taking this medicine.
    • Won't cure your COPD (but it will relieve your symptoms).
    • You'll need to use this medicine for a long time, and you have to take it every day.
    • Can make symptoms of enlarged prostate or urinary blockage worse.
    • Can worsen a certain type of glaucoma.
    • You might feel dizzy or have blurry vision while taking this medicine.
    Tips from our pharmacists for people taking the medication
    AdvairSpiriva
    • Lowers inflammation and opens airways to improve breathing.
    • Starts working in about 30 minutes, but it can take 1 to 2 weeks to feel the full effects.
    • Prevents asthma symptoms, but doesn't treat sudden wheezing or asthma attacks once they start.
    • Use inhaler in a level position, and don't breathe out into the device.
    • Rinse your mouth out with water after each use.
    • Shake inhaler for 5 seconds before you use it.
    • Pump the inhaler 4 times before inhaling the first dose, or if it's been more than a month since your last dose.
    • Call 911 or your doctor if it's hard to breathe or you have an asthma attack while on this medication.
    • Diskus contains lactose, so don't use it if you're allergic to milk protein.
    • Don't swallow the capsule. Insert the capsule into an inhaler device only.
    • Use daily to control your COPD.
    • Starts working the first few hours, but it may take longer to feel full effects.
    • Prevents breathing problems, but doesn't stop sudden cough or wheezing once they start.
    • Don't breathe out into the inhaler.
    • You might feel dizzy and notice changes in your vision.
    • Don't use it if you have an allergy to atropine.
    • Contains lactose, so don't use it if you're allergic to milk protein.
    Learn more
    More about AdvairSide effectsReviews & ratingsAlternativesFDA package insert
    More about SpirivaSide effectsReviews & ratingsAlternativesFDA package insert