Compare Advil Allergy and Congestion Relief vs. Alka-Seltzer Plus Night Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil Allergy And Congestion Relief
(Chlorpheniramine / Ibuprofen / Phenylephrine)

Alka-Seltzer Plus Night Cold And Flu
(Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)

Relieves cold and allergy symptoms. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is an okay combination medicine to relieve pain and congestion. The antihistamine can make you sleepy and the decongestant can keep you awake, so it could affect you either way.Relieves cold and flu symptoms, and helps you sleep. Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms at night, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.913709116214336Advil Allergy and Congestion Relief
Reviews for Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
73%
of people say Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is worth it
30%
say it works well
6%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu

We haven’t found good data for Advil Allergy and Congestion Relief side effects.

FDA side effect reports for Advil Allergy and Congestion Relief »

We haven’t found good data for Alka-Seltzer Plus Night Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Night Cold and Flu »
How it works
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu
Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Phenylephrine is a decongestant that clears your sinuses.Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu
Antihistamine
1st generation
Pain reliever
NSAID
DecongestantOver-the-counter
Pain reliever
Acetaminophen (APAP)
Antihistamine
Ethanolamine derivative
Cough suppressantDecongestantOver-the-counter
Available as
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu
  • Pill
  • Pill
Used for (click to learn more)
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu
Risk factors for serious side effects
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Women of childbearing age
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) risks & warnings »
Pregnancy category
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
  • While taking this, avoid alcohol and other drugs that make you drowsy.
No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) for any amount of time.
No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • While taking this, avoid alcohol and other drugs that make you drowsy.
  • The antihistamine (doxylamine) can help you sleep.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The cough suppressant (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) can help you sleep.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides and risks
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
Tips from our pharmacists for people taking the medication
Advil Allergy and Congestion ReliefAlka-Seltzer Plus Night Cold and Flu
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Chlorpheniramine (the antihistamine ingredient in Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Don't use in kids age 12 years or younger.
  • Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Advil Allergy and Congestion ReliefSide effectsReviews & ratingsAlternativesFDA package insert
More about Alka-Seltzer Plus Night Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert