Compare Advil Allergy And Congestion Relief vs. Tylenol Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves cold and allergy symptoms.

Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is an okay combination medicine to relieve pain and congestion. The antihistamine can make you sleepy and the decongestant can keep you awake, so it could affect you either way.

3.6/ 5 average rating with 1437 reviewsforAdvil Allergy And Congestion Relief
Relieves pain and congestion.

Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.

3.6/ 5 average rating with 1176 reviewsforTylenol Sinus
Upsides
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
Downsides
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
Used for
Dosage forms
  • Pill
  • Pill
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Reviews
1437 reviews so far
73%
saidit'sworth it
30%
saiditworked well
6%
saidit'sa big hassle

Have you used Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)?

Leave a review
1176 reviews so far
74%
saidit'sworth it
31%
saiditworked well
5%
saidit'sa big hassle

Have you used Tylenol Sinus (Acetaminophen / Phenylephrine)?

Leave a review
Side effects
The Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Tylenol Sinus (Acetaminophen / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Stomach bleeding
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Harm to fetus
    • Women of childbearing age
  • Lower kidney function
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking high blood pressure medications
    • Age 65 years or older
  • High blood pressure
    • History of high blood pressure
  • Heart attack or stroke
    • History of heart problems
    • Age 65 years or older
    • Taking with aspirin
See more detailed risks and warnings
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings