Compare Advil Allergy and Congestion Relief vs. Tylenol Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil Allergy And Congestion Relief
(Chlorpheniramine / Ibuprofen / Phenylephrine)

Tylenol Sinus
(Acetaminophen / Phenylephrine)

Relieves cold and allergy symptoms. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is an okay combination medicine to relieve pain and congestion. The antihistamine can make you sleepy and the decongestant can keep you awake, so it could affect you either way.Relieves pain and congestion. Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.913709116214336Advil Allergy and Congestion Relief
Reviews for Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
73%
of people say Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is worth it
30%
say it works well
6%
say it's a big hassle
Reviews for Tylenol Sinus (Acetaminophen / Phenylephrine)
74%
+1% vs. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
31%
+1% vs. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
5%
+1% vs. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
Side effects
Advil Allergy and Congestion ReliefTylenol Sinus

We haven’t found good data for Advil Allergy and Congestion Relief side effects.

FDA side effect reports for Advil Allergy and Congestion Relief »

We haven’t found good data for Tylenol Sinus side effects.

FDA side effect reports for Tylenol Sinus »
How it works
Advil Allergy and Congestion ReliefTylenol Sinus
Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Phenylephrine is a decongestant that clears your sinuses.Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Advil Allergy and Congestion ReliefTylenol Sinus
Antihistamine
1st generation
Pain reliever
NSAID
DecongestantOver-the-counter
Pain reliever
APAP
DecongestantOver-the-counter
Available as
Advil Allergy and Congestion ReliefTylenol Sinus
  • Pill
  • Pill
Used for (click to learn more)
Advil Allergy and Congestion ReliefTylenol Sinus
Risk factors for serious side effects
Advil Allergy and Congestion ReliefTylenol Sinus
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Women of childbearing age
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • Women of childbearing age
Detailed Tylenol Sinus (Acetaminophen / Phenylephrine) risks & warnings »
Pregnancy category
Advil Allergy and Congestion ReliefTylenol Sinus
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
  • While taking this, avoid alcohol and other drugs that make you drowsy.
No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) for any amount of time.
No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • While taking this, avoid alcohol and other drugs that make you drowsy.
No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Advil Allergy and Congestion ReliefTylenol Sinus
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides and risks
Advil Allergy and Congestion ReliefTylenol Sinus
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
Tips from our pharmacists for people taking the medication
Advil Allergy and Congestion ReliefTylenol Sinus
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Chlorpheniramine (the antihistamine ingredient in Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
  • Don't use in kids age 12 years or younger.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Starts working in 30 minutes.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about Advil Allergy and Congestion ReliefSide effectsReviews & ratingsAlternativesFDA package insert
More about Tylenol SinusSide effectsReviews & ratingsAlternativesFDA package insert