Compare Advil Cold and Sinus vs. Allegra D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil Cold And Sinus
(Ibuprofen / Pseudoephedrine)

Allegra D
(Pseudoephedrine / Fexofenadine)

Relieves sinus pain and congestion. Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.Treats allergy symptoms and congestion. Allegra D (Pseudoephedrine / Fexofenadine) is a combination allergy medicine that's useful if you have congestion and runny nose.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.9402061855670105Advil Cold and Sinus
Reviews for Advil Cold And Sinus (Ibuprofen / Pseudoephedrine)
75%
of people say Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is worth it
34%
say it works well
6%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Advil Cold and SinusAllegra D

We haven’t found good data for Advil Cold and Sinus side effects.

FDA side effect reports for Advil Cold and Sinus »
  • Back pain 2%
More Allegra D side effects »
How it works
Advil Cold and SinusAllegra D
Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms and sinus pressure. Ibuprofen (an NSAID) relieves pain and reduces fever. Pseudoephedrine (a decongestant) clears your sinuses.Allegra D (Pseudoephedrine / Fexofenadine) is a combination medicine that relieves allergy symptoms. Fexofenadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itching. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
Advil Cold and SinusAllegra D
Pain reliever
NSAID
DecongestantOver-the-counter
DecongestantAntihistamine
2nd generation
Prescription or OTC
Available as
Advil Cold and SinusAllegra D
  • Pill
  • Extended release
Used for (click to learn more)
Advil Cold and SinusAllegra D
Risk factors for serious side effects
Advil Cold and SinusAllegra D
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
  • History of high blood pressure
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
Detailed Allegra D (Pseudoephedrine / Fexofenadine) risks & warnings »
Pregnancy category
Advil Cold and SinusAllegra D
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) for any amount of time.
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Advil Cold and SinusAllegra D
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
  • Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
  • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
  • Available without a prescription in the drugstore.
  • It has two medications that work in different ways to help relieve nasal symptoms.
  • The antihistamine (fexofenadine) is useful for relieving itchy eyes, runny nose, or constant sneezing.
  • The decongestant (pseudoephedrine) is very good at relieving congestion.
Downsides and risks
Advil Cold and SinusAllegra D
  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
  • Has more side effects than Allegra since it has pseudoephedrine in it.
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • You must show a photo ID to buy this from behind the pharmacy counter. There's a maximum limit on how much you can buy in the pharmacy at a time.
Tips from our pharmacists for people taking the medication
Advil Cold and SinusAllegra D
  • Starts working in 30 minutes.
  • You need to show an ID to buy Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Take it after eating to avoid getting an upset stomach.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Be careful taking Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) if you have a history of bleeding problems or ulcers since it can make them worse.
  • Talk to your doctor if symptoms don't get better in 1 week.
  • It works best if you have nasal congestion and a runny nose.
  • Take on an empty stomach, 1 hour before eating or 2 hours after eating.
  • Shouldn't be used in kids younger than 12 years old.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
  • Can cause dizziness, headache, or a fast heartbeat.
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
Learn more
More about Advil Cold and SinusSide effectsReviews & ratingsAlternativesFDA package insert
More about Allegra DSide effectsReviews & ratingsAlternativesFDA package insert