Compare Advil Congestion Relief vs. Tylenol Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil Congestion Relief
(Ibuprofen / Phenylephrine)

Tylenol Sinus
(Acetaminophen / Phenylephrine)

Relieves pain and congestion. Advil Congestion Relief (Ibuprofen / Phenylephrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.Relieves pain and congestion. Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.902222222222222Advil Congestion Relief
Reviews for Advil Congestion Relief (Ibuprofen / Phenylephrine)
73%
of people say Advil Congestion Relief (Ibuprofen / Phenylephrine) is worth it
32%
say it works well
7%
say it's a big hassle
Reviews for Tylenol Sinus (Acetaminophen / Phenylephrine)
74%
+1% vs. Advil Congestion Relief (Ibuprofen / Phenylephrine)
31%
1% vs. Advil Congestion Relief (Ibuprofen / Phenylephrine)
5%
+2% vs. Advil Congestion Relief (Ibuprofen / Phenylephrine)
Side effects
Advil Congestion ReliefTylenol Sinus

We haven’t found good data for Advil Congestion Relief side effects.

FDA side effect reports for Advil Congestion Relief »

We haven’t found good data for Tylenol Sinus side effects.

FDA side effect reports for Tylenol Sinus »
How it works
Advil Congestion ReliefTylenol Sinus
Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Phenylephrine is a decongestant that clears your sinuses.Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Advil Congestion ReliefTylenol Sinus
Pain reliever
NSAID
DecongestantOver-the-counter
Pain reliever
APAP
DecongestantOver-the-counter
Available as
Advil Congestion ReliefTylenol Sinus
  • Pill
  • Pill
Used for (click to learn more)
Advil Congestion ReliefTylenol Sinus
Risk factors for serious side effects
Advil Congestion ReliefTylenol Sinus
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
  • History of high blood pressure
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Congestion Relief (Ibuprofen / Phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • Women of childbearing age
Detailed Tylenol Sinus (Acetaminophen / Phenylephrine) risks & warnings »
Pregnancy category
Advil Congestion ReliefTylenol Sinus
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Congestion Relief (Ibuprofen / Phenylephrine) for any amount of time.
No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Advil Congestion ReliefTylenol Sinus
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides and risks
Advil Congestion ReliefTylenol Sinus
  • If you don't really need both of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
Tips from our pharmacists for people taking the medication
Advil Congestion ReliefTylenol Sinus
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Follow age-specific dosing instructions on how much to take. Don't take more than what's recommended on the package.
  • Starts working in 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take.
  • Starts working in 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about Advil Congestion ReliefSide effectsReviews & ratingsAlternativesFDA package insert
More about Tylenol SinusSide effectsReviews & ratingsAlternativesFDA package insert