Compare Advil PM vs. Tylenol PM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves pain and helps you sleep.

Advil Pm (Diphenhydramine / Ibuprofen) works well at relieving pain and also helps you sleep.

Relieves pain and helps you sleep.

Tylenol Pm (Acetaminophen / Diphenhydramine) works well at relieving pain and also helps you sleep.

Upsides
  • Advil Pm (Diphenhydramine / Ibuprofen) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Tylenol Pm (Acetaminophen / Diphenhydramine) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
Downsides
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can only take one dose in 24 hours.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Can only take one dose in 24 hours.
Used for
Dosage forms
  • Pill
  • Pill
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Reviews
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Side effects
The Advil Pm (Diphenhydramine / Ibuprofen) FDA package insert doesn’t have numbers about how common side effects are.
The Tylenol Pm (Acetaminophen / Diphenhydramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Stomach bleeding
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
  • Harm to fetus
    • Women of childbearing age
  • Heart attack or stroke
    • Taking with aspirin
  • Heart failure
    • Age 65 years or older
    • High blood pressure
    • Heart disease
    • Kidney disease
  • Increased falls
    • History of falls
    • Age 65 or older
    • Taking other drugs that make you drowsy or dizzy
See more detailed risks and warnings
  • Increased falls
    • History of falls
    • Age 65 or older
    • Taking other drugs that make you drowsy or dizzy
  • Liver damage
    • Drinking more than 3 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • Antihistamine side effects
    • Age 65 years or older
    • Glaucoma
    • Benign prostatic hypertrophy (BPH)
See more detailed risks and warnings