Compare Advil PM vs. Tylenol PM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil Pm
(Diphenhydramine / Ibuprofen)

Tylenol Pm
(Acetaminophen / Diphenhydramine)

Relieves pain and helps you sleep. Advil Pm (Diphenhydramine / Ibuprofen) works well at relieving pain and also helps you sleep.Relieves pain and helps you sleep. Tylenol Pm (Acetaminophen / Diphenhydramine) works well at relieving pain and also helps you sleep.
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Reviews & ratings
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Side effects
Advil PMTylenol PM

We haven’t found good data for Advil PM side effects.

FDA side effect reports for Advil PM »

We haven’t found good data for Tylenol PM side effects.

FDA side effect reports for Tylenol PM »
How it works
Advil PMTylenol PM
Advil Pm (Diphenhydramine / Ibuprofen) is a combination medicine that treats cold and flu symptoms. Ibuprofen is an NSAID that relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.Tylenol Pm (Acetaminophen / Diphenhydramine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.
Type of medication
Advil PMTylenol PM
Antihistamine
1st generation
Pain reliever
NSAID
Over-the-counter
Pain reliever
Acetaminophen (APAP)
Antihistamine
1st generation
Over-the-counter
Available as
Advil PMTylenol PM
  • Pill
  • Pill
Used for (click to learn more)
Advil PMTylenol PM
Risk factors for serious side effects
Advil PMTylenol PM
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
  • Taking with aspirin
  • Age 65 years or older
  • High blood pressure
  • Heart disease
  • Kidney disease
  • History of falls
  • Age 65 or older
  • Taking other drugs that make you drowsy or dizzy
Detailed Advil Pm (Diphenhydramine / Ibuprofen) risks & warnings »
  • History of falls
  • Age 65 or older
  • Taking other drugs that make you drowsy or dizzy
  • Drinking more than 3 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
Detailed Tylenol Pm (Acetaminophen / Diphenhydramine) risks & warnings »
Pregnancy category
Advil PMTylenol PM
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
Food
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
  • Diphenhydramine, also known as Benadryl, is an antihistamine in Advil Pm (Diphenhydramine / Ibuprofen) that can make you feel dizzy or drowsy. People who are at a higher risk of falls should avoid using Advil Pm (Diphenhydramine / Ibuprofen).
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • Diphenhydramine, also known as Benadryl, is an antihistamine in Tylenol Pm (Acetaminophen / Diphenhydramine) that can make you feel dizzy or drowsy. People who are at a higher risk of falls should avoid using Tylenol Pm (Acetaminophen / Diphenhydramine).
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Advil PMTylenol PM
  • Advil Pm (Diphenhydramine / Ibuprofen) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Tylenol Pm (Acetaminophen / Diphenhydramine) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
Downsides and risks
Advil PMTylenol PM
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can only take one dose in 24 hours.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • Can only take one dose in 24 hours.
Tips from our pharmacists for people taking the medication
Advil PMTylenol PM
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) if you're pregnant.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about Advil PMSide effectsReviews & ratingsAlternativesFDA package insert
More about Tylenol PMSide effectsReviews & ratingsAlternativesFDA package insert