Compare Aggrenox vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aggrenox
(aspirin / dipyridamole)

Coumadin
(warfarin)

Prevents blood clots that can cause a stroke. Aggrenox (Aspirin / Dipyridamole) prevents blood clots and stroke, but cheaper options are available that work just as well.Prevents blood clots. Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.
Reviews & ratings
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Have you used Aggrenox (aspirin / dipyridamole)?
Worth itNot sureNot worth it
Reviews for Coumadin
61%
-11% worse vs. Aggrenox
54%
+46% better vs. Aggrenox
21%
+21% better vs. Aggrenox
513 reviews
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it
Side effects
AggrenoxCoumadin
  • Headache 10%
  • Dyspepsia 3%
  • Abdominal Pain 6%
  • Nausea 6%
  • Diarrhea 3%
  • Vomiting 1%
  • Arthralgia 1%
More Aggrenox side effects »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
How it works
AggrenoxCoumadin
Aggrenox (Aspirin / Dipyridamole) is an antiplatelet blood thinner. It is a combination medication with two ingredients, aspirin and dipyridamole. Both make it harder for your body to form blood clots.Coumadin (warfarin) prevents blood clots from forming. It doesn't break up clots that already exist. It can only stop new ones from forming or old ones from getting bigger.
Type of medication
AggrenoxCoumadin
Prescription onlyPrescription only
Available as
AggrenoxCoumadin
  • Pill
  • Pill
Used for
AggrenoxCoumadin
Risk factors for serious side effects
AggrenoxCoumadin
  • Children 18 years or younger recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 or older
  • Also taking other blood thinners
  • Drinking 3 or more alcoholic drinks a day
Detailed Aggrenox (aspirin / dipyridamole) risks & warnings »
  • Coumadin (warfarin) dose too high
  • Age greater than 65 year
  • History of stomach bleeding
  • High blood pressure
  • Kidney or liver problems
Detailed Coumadin (warfarin) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Interactions
AggrenoxCoumadin
No interactions related info.
  • Coumadin (warfarin) interacts with many drugs and supplements. This can increase your risk of bleeding or of developing a new blood clot. If you start a new medication or change your diet, let your doctor know so they can change your dose if necessary.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
Food
AggrenoxCoumadin
  • Do not crush or chew capsules. Can take with or without food.
No food related info.
Kidneys and liver
AggrenoxCoumadin
  • Do not use Aggrenox (Aspirin / Dipyridamole) if you have severe kidney disease.
No kidneys and liver related info.
Upsides and benefits
AggrenoxCoumadin
  • This helps to prevent strokes for people who had a stroke or TIA (transient ischemic attack) before.
  • In clinical studies, Aggrenox (Aspirin / Dipyridamole) lowered the chance of another stroke for a person with a previous stroke or mini-stroke (TIA) by 36%.
  • Works better than either aspirin or dipyridamole alone to prevent strokes.
  • Works as well as Plavix (clopidogrel), another antiplatelet medication, to prevent stroke.
  • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
  • Coumadin (warfarin) comes in numerous strengths.
  • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
Downsides and risks
AggrenoxCoumadin
  • Raises your risk for bleeding and bruising.
  • Has to be taken twice a day unlike Plavix that only has to be taken once daily.
  • Can be more expensive than other alternatives that are available as a generic.
  • Can't be used by people with an aspirin allergy, or a history of stomach ulcers.
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
  • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
Tips from our pharmacists for people taking the medication
AggrenoxCoumadin
  • Take twice daily.
  • Do not crush or chew capsules. Can take with or without food.
  • Aggrenox (Aspirin / Dipyridamole) can cause unexpected bleeding or bruising.
  • Don't take if you're allergic to aspirin.
  • Headache is a common side effect, but it often goes away after the first week of use.
  • Prevents clots from forming or getting bigger. It doesn't break up clots that already exist.
  • Take Coumadin (warfarin) exactly as your doctor tells you.
  • Once you're taking Coumadin (warfarin), it'll take longer for your body to heal if you get cut or bruised. Call your doctor if you notice any unusual bleeding or bruising.
  • Carry a list of your medications with you or wear a medical bracelet that says you're on Coumadin (warfarin) in case you have a medical emergency.
  • Your doctor will check your blood regularly for the first few months that you're taking Coumadin (warfarin).
  • To get the best results, don't fall behind on taking your other medicines and eat the same amount of vegetables each day.
Learn more
More about AggrenoxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aggrenox (aspirin / dipyridamole)?
Worth itNot sureNot worth it
More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it