Compare Aggrenox vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aggrenox
(Aspirin / Dipyridamole)

Coumadin
(Warfarin)

Prevents blood clots that can cause a stroke. Aggrenox (Aspirin / Dipyridamole) prevents blood clots and stroke, but cheaper options are available that work just as well.Prevents blood clots. Coumadin (Warfarin) is an old, cheap, and effective medicine to prevent blood clots, but it requires some monitoring, dose adjustments, and even lifestyle changes.
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Reviews & ratings
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Reviews for Coumadin (Warfarin)
61%
39% vs. Aggrenox (Aspirin / Dipyridamole)
54%
46% vs. Aggrenox (Aspirin / Dipyridamole)
21%
21% vs. Aggrenox (Aspirin / Dipyridamole)
Side effects
AggrenoxCoumadin
  • Headache 10%
  • Abdominal pain 6%
  • Nausea 6%
  • Diarrhea 3%
  • Indigestion 3%
  • Hemorrhage nos 2%
  • Back pain 1%
  • Dizziness 1%
  • Black "tarry" stools 1%
  • Feeling unwell 1%
More Aggrenox side effects »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
How it works
AggrenoxCoumadin
Aggrenox (Aspirin / Dipyridamole) is an antiplatelet blood thinner. It is a combination medication with two ingredients, aspirin and dipyridamole. Both make it harder for your body to form blood clots.Coumadin (Warfarin) is an anticoagulant blood thinner. It lowers chemicals called clotting factors so that it's harder for your body to form blood clots.
Type of medication
AggrenoxCoumadin
Anticoagulant
Anti-platelet
Prescription only
Anticoagulant
Vitamin K antagonist
Prescription only
Available as
AggrenoxCoumadin
  • Pill
  • Pill
Used for (click to learn more)
AggrenoxCoumadin
Risk factors for serious side effects
AggrenoxCoumadin
  • Children 18 years or younger recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 or older
  • Also taking other blood thinners
  • Drinking 3 or more alcoholic drinks a day
  • Asthma
  • Rhinitis
  • Nasal Polyps
  • Aspirin Allergy
  • NSAID Allergy
    • Hemophilia
    • von Willebrand's disease
    • low blood platelet count
    • Also taking other blood thinners
    • History of stroke or TIA
    • Liver disease
    • Coronary artery disease
    • Angina
    • Prior heart attack
    • Coronary artery disease
    • Angina
    • History of heart attack
    • History of heart bypass surgery
    • History of coronary artery stent placement
      • Prior episodes of low blood pressure
      • Taking blood pressure medications
      • Severe kidney disease
      Detailed Aggrenox (Aspirin / Dipyridamole) risks & warnings »
      • Dose too high
      • Age greater than 65
      • History of gastrointestinal bleeding
      • High blood pressure
      • Kidney or liver problems
      • Drug interactions
      • Change in lifestyle or diet
      • Illnesses
      • Alcohol
      • Certain genetic makeup
        • Women of childbearing age
        Detailed Coumadin (Warfarin) risks & warnings »
        Pregnancy category
        AggrenoxCoumadin
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.
        • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
        Food
        • Do not crush or chew capsules. Can take with or without food.
        • Eat foods containing consistent amounts of Vitamin K.
        Kidneys and liver
        • Do not use Aggrenox (Aspirin / Dipyridamole) if you have severe kidney disease.
        No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        AggrenoxCoumadin
        • This helps to prevent strokes for people who had a stroke or TIA (transient ischemic attack) before.
        • In clinical studies, Aggrenox (Aspirin / Dipyridamole) lowered the chance of another stroke for a person with a previous stroke or mini-stroke (TIA) by 36%.
        • Works better than either aspirin or dipyridamole alone to prevent strokes.
        • Works as well as Plavix (clopidogrel), another antiplatelet medication, to prevent stroke.
        • Oral blood-thinning medicine that prevents blood clots from forming or getting bigger.
        • Prevents complications of blood clots that can cause extreme discomfort or death. Examples include stroke (blood clots in the brain), pulmonary embolism (blood clots in the lungs causing trouble breathing), or deep vein thrombosis (blood clots in the legs causing pain and blood vessel damage).
        • Has an antidote, Vitamin K, in case of a major accidental bleeding.
        • Coumadin (Warfarin) has been around for a long time, so we know a lot about how well it works and what the risks are.
        • It's dirt cheap.
        Downsides and risks
        AggrenoxCoumadin
        • Raises your risk for bleeding and bruising.
        • Has to be taken twice a day unlike Plavix that only has to be taken once daily.
        • Can be more expensive than other alternatives that are available as a generic.
        • Can't be used by people with an aspirin allergy, or a history of stomach ulcers.
        • Raises your risk of bleeding and bruising.
        • Requires routine blood testing (called an INR) to see how well the medicine is working for you and to make the dose just right for you.
        • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
        • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
        Tips from our pharmacists for people taking the medication
        AggrenoxCoumadin
        • Take twice daily.
        • Do not crush or chew capsules. Can take with or without food.
        • Aggrenox (Aspirin / Dipyridamole) can cause unexpected bleeding or bruising.
        • Don't take if you're allergic to aspirin.
        • Headache is a common side effect, but it often goes away after the first week of use.
        • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
        • The amount you need depends on your diet, other medical problems, and genes.
        • Take it exactly as instructed.
        • Can raise your risk of bleeding or bruising.
        • Requires regular blood tests to get your dose right.
        • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
        • Eat foods containing consistent amounts of Vitamin K.
        • Tell your doctor immediately if you fell or if you have unusual bleeding, bruising, swelling, or changes in vision and coordination.
        • Get a medical bracelet so that people know you're on a blood thinner during an emergency situation.
        Learn more
        More about AggrenoxSide effectsReviews & ratingsAlternativesFDA package insert
        More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert