Compare Aggrenox vs. Heparin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aggrenox (Aspirin / Dipyridamole)

Prescription only


Prescription only
Prevents blood clots that can cause a stroke.

Aggrenox (Aspirin / Dipyridamole) prevents blood clots and stroke, but cheaper options are available that work just as well.

Prevents blood clots.

Heparin is a good anticoagulant that prevents blood clots. However, you'll need to get frequent blood tests to make sure it's working well.

  • This helps to prevent strokes for people who had a stroke or TIA (transient ischemic attack) before.
  • In clinical studies, Aggrenox (Aspirin / Dipyridamole) lowered the chance of another stroke for a person with a previous stroke or mini-stroke (TIA) by 36%.
  • Works better than either aspirin or dipyridamole alone to prevent strokes.
  • Works as well as Plavix (clopidogrel), another antiplatelet medication, to prevent stroke.
  • Safe to use in pregnancy and if you're breast feeding.
  • There are other medications that can help stop unexpected bleeding while taking Heparin.
  • Available as a generic medication.
  • Usually used in the hospital, but can be given at home too.
  • Raises your risk for bleeding and bruising.
  • Has to be taken twice a day unlike Plavix that only has to be taken once daily.
  • Can be more expensive than other alternatives that are available as a generic.
  • Can't be used by people with an aspirin allergy, or a history of stomach ulcers.
  • You'll need to get labs/blood draws done on a regular basis to make sure the drug is working and to make sure you don't get unexpected side effects.
  • You can be at higher risk for bleeding or clotting while taking Heparin compared to other anticoagulants.
Used for
Dosage forms
  • Pill
  • Injection
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Side effects
9possible side effects
  • Headache
  • Dyspepsia
  • Abdominal Pain
  • Nausea
  • Diarrhea
  • Vomiting
  • Pain
  • Fatigue
  • Arthralgia
See more detailed side effects
The Heparin FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Brain damage or death from Reyes Syndrome

    Children 18 years or younger recovering from viral infections

  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Serious allergic reactions


    ...and 4 more risk factors

  • Bruising or bleeding


    ...and 5 more risk factors

  • Worsening heart disease

    Coronary artery disease

    ...and 2 more risk factors

  • Taking the wrong aspirin dose for heart protection

    Coronary artery disease

    ...and 4 more risk factors

  • Low blood pressure

    Prior episodes of low blood pressure

    ...and 1 more risk factors

  • Kidney damage

    Severe kidney disease

See more detailed risks and warnings
  • Unusual bleeding

    History of bleeding problems

    ...and 2 more risk factors

  • Clotting problems

    Heparin-induced thrombocytopenia

See more detailed risks and warnings