Compare Aggrenox vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aggrenox
(Aspirin / Dipyridamole)

Xarelto
(Rivaroxaban)

Prevents blood clots that can cause a stroke. Aggrenox (Aspirin / Dipyridamole) prevents blood clots and stroke, but cheaper options are available that work just as well.Prevents blood clots. Xarelto (Rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.
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Reviews & ratings
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Have you used Aggrenox (Aspirin / Dipyridamole)?
Worth itNot sureNot worth it

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Have you used Xarelto (Rivaroxaban)?
Worth itNot sureNot worth it
Side effects
AggrenoxXarelto
  • Headache 10%
  • Indigestion 3%
  • Abdominal pain 6%
  • Nausea 6%
  • Diarrhea 3%
  • Vomiting 1%
  • Joint pain 1%
More Aggrenox side effects »
  • Major bleeding needing transfusion 4%
  • Bleeding in the stomach & intestines 2%
  • Complaints of bleeding 28%
  • Clinically relevant but not major bleeding 9%
  • Back pain 3%
  • Upper abdominal pain 2%
  • Joint arthritis 1%
  • Any bleeding event after hip or knee replacement surgery 6%
  • Any side effect causing stopping of xarelto (rivaroxaban) 4%
  • Wound drainage 3%
More Xarelto side effects »
How it works
AggrenoxXarelto
Aggrenox (Aspirin / Dipyridamole) is an antiplatelet blood thinner. It is a combination medication with two ingredients, aspirin and dipyridamole. Both make it harder for your body to form blood clots.Xarelto (Rivaroxaban) is an anticoagulant that stops blood clots from forming.
Type of medication
AggrenoxXarelto
Prescription only
Prescription only
Available as
AggrenoxXarelto
  • Pill
  • Pill
Used for
AggrenoxXarelto
Risk factors for serious side effects
AggrenoxXarelto
  • Children 18 years or younger recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 or older
  • Also taking other blood thinners
  • Drinking 3 or more alcoholic drinks a day
  • Asthma
  • Rhinitis
  • Nasal Polyps
  • Aspirin Allergy
  • NSAID Allergy
    • Hemophilia
    • von Willebrand's disease
    • low blood platelet count
    • Also taking other blood thinners
    • History of stroke or TIA
    • Liver disease
    • Coronary artery disease
    • Angina
    • Prior heart attack
    • Coronary artery disease
    • Angina
    • History of heart attack
    • History of heart bypass surgery
    • History of coronary artery stent placement
      • Prior episodes of low blood pressure
      • Taking blood pressure medications
      • Severe kidney disease
      Detailed Aggrenox (Aspirin / Dipyridamole) risks & warnings »
      • Stopping Xarelto (Rivaroxaban) too soon
      • Artificial heart valve
      • Spinal puncture (spinal tap)
      • Getting anesthesia in the spine (epidural anesthesia)
      • History of bleeding problems
      • Severe high blood pressure
      • Age 65 or older
      • Drug interactions
      • Taking NSAIDs, aspirin, or other blood-thinning medicines
      • Current kidney problems
      • Current liver problems
      Detailed Xarelto (Rivaroxaban) risks & warnings »
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Interactions
      AggrenoxXarelto
      No interactions related info.
      • Xarelto (Rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
      Food
      AggrenoxXarelto
      • Do not crush or chew capsules. Can take with or without food.
      • Like all blood thinners, it will take a little longer for your blood to clot if you start bleeding while you're taking Xarelto (Rivaroxaban). Call your doctor if you notice bleeding that won't stop, a bruise that won't go away or gets worse, pink or brown urine, bright red or dark tarry stool, nose bleeds, or if you start coughing up blood.
      Kidneys and liver
      AggrenoxXarelto
      • Do not use Aggrenox (Aspirin / Dipyridamole) if you have severe kidney disease.
      • Xarelto (Rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to avoid other side effects.
      Upsides and benefits
      AggrenoxXarelto
      • This helps to prevent strokes for people who had a stroke or TIA (transient ischemic attack) before.
      • In clinical studies, Aggrenox (Aspirin / Dipyridamole) lowered the chance of another stroke for a person with a previous stroke or mini-stroke (TIA) by 36%.
      • Works better than either aspirin or dipyridamole alone to prevent strokes.
      • Works as well as Plavix (clopidogrel), another antiplatelet medication, to prevent stroke.
      • Studies show that Xarelto (Rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
      • Xarelto (Rivaroxaban) doesn't require regular blood tests or frequent dose changes.
      • Xarelto (Rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
      Downsides and risks
      AggrenoxXarelto
      • Raises your risk for bleeding and bruising.
      • Has to be taken twice a day unlike Plavix that only has to be taken once daily.
      • Can be more expensive than other alternatives that are available as a generic.
      • Can't be used by people with an aspirin allergy, or a history of stomach ulcers.
      • Xarelto (Rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
      • Xarelto (Rivaroxaban) isn't available as a generic medication.
      • There are no antidotes to stop bleeding caused by taking too much Xarelto (Rivaroxaban).
      • You can't take Xarelto (Rivaroxaban) if you are pregnant.
      Tips from our pharmacists for people taking the medication
      AggrenoxXarelto
      • Take twice daily.
      • Do not crush or chew capsules. Can take with or without food.
      • Aggrenox (Aspirin / Dipyridamole) can cause unexpected bleeding or bruising.
      • Don't take if you're allergic to aspirin.
      • Headache is a common side effect, but it often goes away after the first week of use.
      • Xarelto (Rivaroxaban) is an prevents blood from clotting, so it's important not to miss a dose. If you miss your daily dose, take it as soon as you remember that day. Just don't take two doses close to each other.
      • If you completely forget to take a dose, call your doctor right away.
      • When taking Xarelto (Rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
      • You can crush the pills and mix it with a spoonful of applesauce, but make sure to eat some food and drink a glass of water right away.
      Learn more
      More about AggrenoxSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Aggrenox (Aspirin / Dipyridamole)?
      Worth itNot sureNot worth it
      More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Xarelto (Rivaroxaban)?
      Worth itNot sureNot worth it