Compare Aggrenox vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aggrenox
(Aspirin / Dipyridamole)

Xarelto
(Rivaroxaban)

Prevents blood clots that can cause a stroke. Aggrenox (Aspirin / Dipyridamole) prevents blood clots and stroke, but cheaper options are available that work just as well.Prevents blood clots. Xarelto (Rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.
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Side effects
AggrenoxXarelto
  • Headache 10%
  • Abdominal pain 6%
  • Nausea 6%
  • Diarrhea 3%
  • Indigestion 3%
  • Hemorrhage nos 2%
  • Back pain 1%
  • Dizziness 1%
  • Black "tarry" stools 1%
  • Feeling unwell 1%
More Aggrenox side effects »
  • Back pain 3%
More Xarelto side effects »
How it works
AggrenoxXarelto
Aggrenox (Aspirin / Dipyridamole) is an antiplatelet blood thinner. It is a combination medication with two ingredients, aspirin and dipyridamole. Both make it harder for your body to form blood clots.Xarelto (Rivaroxaban) is an anticoagulant that stops the formation of blood clots.
Type of medication
AggrenoxXarelto
Anticoagulant
Anti-platelet
Prescription only
Anticoagulant
Factor Xa inhibitor
Prescription only
Available as
AggrenoxXarelto
  • Pill
  • Pill
Used for (click to learn more)
AggrenoxXarelto
Risk factors for serious side effects
AggrenoxXarelto
  • Children 18 years or younger recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 or older
  • Also taking other blood thinners
  • Drinking 3 or more alcoholic drinks a day
  • Asthma
  • Rhinitis
  • Nasal Polyps
  • Aspirin Allergy
  • NSAID Allergy
    • Hemophilia
    • von Willebrand's disease
    • low blood platelet count
    • Also taking other blood thinners
    • History of stroke or TIA
    • Liver disease
    • Coronary artery disease
    • Angina
    • Prior heart attack
    • Coronary artery disease
    • Angina
    • History of heart attack
    • History of heart bypass surgery
    • History of coronary artery stent placement
      • Prior episodes of low blood pressure
      • Taking blood pressure medications
      • Severe kidney disease
      Detailed Aggrenox (Aspirin / Dipyridamole) risks & warnings »
      • Stopping Xarelto (Rivaroxaban) too soon
      • Artificial heart valve
      • Spinal puncture (spinal tap)
      • Getting anesthesia in the spine (epidural anesthesia)
      • History of bleeding problems
      • Severe high blood pressure
      • Age 65 or older
      • Drug interactions
      • Taking NSAIDs, aspirin, or other blood-thinning medicines
      • Current kidney problems
      • Current liver problems
      Detailed Xarelto (Rivaroxaban) risks & warnings »
      Pregnancy category
      AggrenoxXarelto
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      • Do not crush or chew capsules. Can take with or without food.
      • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
      • Take Xarelto (Rivaroxaban) with food and a full glass of water.
      Kidneys and liver
      • Do not use Aggrenox (Aspirin / Dipyridamole) if you have severe kidney disease.
      • Xarelto (Rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to prevent increased risk for side effects.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      AggrenoxXarelto
      • This helps to prevent strokes for people who had a stroke or TIA (transient ischemic attack) before.
      • In clinical studies, Aggrenox (Aspirin / Dipyridamole) lowered the chance of another stroke for a person with a previous stroke or mini-stroke (TIA) by 36%.
      • Works better than either aspirin or dipyridamole alone to prevent strokes.
      • Works as well as Plavix (clopidogrel), another antiplatelet medication, to prevent stroke.
      • Studies have shown that Xarelto (Rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and reducing bleeding.
      • Xarelto (Rivaroxaban) doesn't require regular blood testing or frequent dose adjustments.
      • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
      Downsides and risks
      AggrenoxXarelto
      • Raises your risk for bleeding and bruising.
      • Has to be taken twice a day unlike Plavix that only has to be taken once daily.
      • Can be more expensive than other alternatives that are available as a generic.
      • Can't be used by people with an aspirin allergy, or a history of stomach ulcers.
      • Xarelto (Rivaroxaban) can increase your risk of bleeding. Call your doctor right away if there is blood in your phlegm, urine, or stool (look for black, tarry stools).
      • Xarelto (Rivaroxaban) isn't available as a generic medication.
      • There are no antidotes to stop bleeding caused by taking too much Xarelto (Rivaroxaban).
      • Can't take during pregnancy.
      Tips from our pharmacists for people taking the medication
      AggrenoxXarelto
      • Take twice daily.
      • Do not crush or chew capsules. Can take with or without food.
      • Aggrenox (Aspirin / Dipyridamole) can cause unexpected bleeding or bruising.
      • Don't take if you're allergic to aspirin.
      • Headache is a common side effect, but it often goes away after the first week of use.
      • Xarelto (Rivaroxaban) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
      • When taking Xarelto (Rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
      • Take Xarelto (Rivaroxaban) with food and a full glass of water.
      • You can crush the tablets and mix with applesauce.
      Learn more
      More about AggrenoxSide effectsReviews & ratingsAlternativesFDA package insert
      More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert