Compare Aldactazide vs. Aldactone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aldactazide
(Spironolactone / Hydrochlorothiazide)

Aldactone
(Spironolactone)

Lowers blood pressure. Removes extra water from your body. Aldactazide (Spironolactone / Hydrochlorothiazide) removes excess fluid in your body and lowers your blood pressure, while helping keep your potassium levels safe.Removes extra water from your body. Aldactone (Spironolactone) is helpful when added to another diuretic to get rid of excess fluid in your body. Doesn't work well on its own.
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Reviews & ratings
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Side effects
AldactazideAldactone

We haven’t found good data for Aldactazide side effects.

FDA side effect reports for Aldactazide »

We haven’t found good data for Aldactone side effects.

FDA side effect reports for Aldactone »
How it works
AldactazideAldactone
Aldactazide (Spironolactone / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure with two diuretics (water pills), hydrochlorothiazide and spironolactone. They act on different parts of your kidney to get rid of extra fluids.Aldactone (Spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body.
Type of medication
AldactazideAldactone
Antihypertensive
Diuretic
Diuretic
Prescription only
Antihypertensive
Diuretic
Prescription only
Available as
AldactazideAldactone
  • Pill
  • Pill
Used for (click to learn more)
AldactazideAldactone
Risk factors for serious side effects
AldactazideAldactone
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    • Current kidney problems
    • Medicine that affects electrolytes
    • History of sulfa allergies
    • Taking with alcohol
    • Taking other medicines that make you less alert
      Detailed Aldactazide (Spironolactone / Hydrochlorothiazide) risks & warnings »
        • Taking with alcohol
        • Taking other medicines that make you less alert
        • Current kidney problems
        • Medicine that increase potassium
        • Use of salt substitute
          Detailed Aldactone (Spironolactone) risks & warnings »
          Pregnancy category
          AldactazideAldactone
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          • Needs blood tests to monitor electrolytes and kidney function.
          • Get your blood pressure, potassium, and kidney function checked one week after starting the medicine, then routinely after.
          • Aldactazide (Spironolactone / Hydrochlorothiazide) can increase the amount of potassium in your body. High potassium can cause heart problems. Baseline and routine blood tests are needed to monitor your potassium and kidney function.
          • Aldactazide (Spironolactone / Hydrochlorothiazide) can affect levels of certain electrolytes (sodium, magnesium) that can cause muscle weakness/spasms or unexplained tiredness. Baseline and routine blood tests are needed to monitor your electrolytes and kidney function.
          • Needs to have blood tests done to monitor electrolyte levels and kidney function.
          • Aldactone (Spironolactone) can increase the amount of potassium in your body. High potassium can cause heart problems. Baseline and routine blood tests are needed to monitor your potassium and kidney function.
          Sex
          No specific sex-related info.
          • You can have breast pain/swelling, irregular periods (women), or trouble with sexual performance.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          AldactazideAldactone
          • Lowers the risk of heart attack and stroke.
          • Gets rid of extra fluids in your body.
          • Helpful for people who tend to have low potassium levels.
          • Has a low risk of causing muscle problems due to low potassium levels in your blood.
          • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
          • Can lower blood pressure.
          • Reduces the risk of death in people with heart failure.
          • Has a low risk of causing muscle problems due to low potassium levels in your blood.
          Downsides and risks
          AldactazideAldactone
          • Many possible side effects, especially when higher doses are used.
          • Needs blood tests to monitor electrolytes and kidney function.
          • Can make you urinate more often.
          • Can make you sensitive to sunlight.
          • Shouldn't take it if you have a sulfa allergy.
          • Can increase the risk of tumor growth.
          • Not very good at getting rid of excess fluids on its own. Should be used with another drug to help get rid of excess fluids.
          • Has many possible side effects, especially when higher doses are used.
          • Needs to have blood tests done to monitor electrolyte levels and kidney function.
          • Can increase the risk of tumor growth.
          Tips from our pharmacists for people taking the medication
          AldactazideAldactone
          • Makes you urinate more often, so don't take it at bedtime.
          • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how it affects you.
          • Get your blood pressure, potassium, and kidney function checked one week after starting the medicine, then routinely after.
          • Tell your doctor about any dizziness, muscle weakness, skin changes, red or black tarry stool.
          • Can make your skin more sensitive to sun, so use proper protections.
          • Don't use supplements or salt substitutes that are high in potassium.
          • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how the medicine affects you.
          • You can have breast pain/swelling, irregular periods (women), or trouble with sexual performance.
          • Tell your doctor about any muscle weakness, skin changes, red or black tarry stool.
          • Can take 2 to 3 days to see full diuretic effects and 2 to 3 weeks to see blood pressure lowering effects.
          • Don't use supplements or salt substitutes that are high in potassium.
          Learn more
          More about AldactazideSide effectsAlternativesFDA package insert
          More about AldactoneSide effectsReviews & ratingsAlternativesFDA package insert