Compare Aldactazide vs. Inspra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aldactazide
(spironolactone / hydrochlorothiazide)

Inspra
(eplerenone)

Lowers blood pressure. Removes extra water from your body. Aldactazide (Spironolactone / Hydrochlorothiazide) removes excess fluid in your body and lowers your blood pressure, while helping keep your potassium levels safe.Helps lower blood pressure and protect the heart in people with heart failure. Inspra (eplerenone) lowers blood pressure and can help remove fluid when it's used with other drugs. It reduces the risk of death in people with heart failure and is usually used when people can't take spironolactone.
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Coupons for Aldactazide
Best available price for 30 (25mg/25mg) tablets of aldactazide
Coupons for Inspra
Best available price for 30 (25mg) tablets of inspra
Reviews & ratings
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Have you used Aldactazide (spironolactone / hydrochlorothiazide)?
Worth itNot sureNot worth it

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Have you used Inspra (eplerenone)?
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Side effects
AldactazideInspra

We haven’t found good data for Aldactazide side effects.

FDA side effect reports for Aldactazide »
  • High potassium 1%
  • Abnormal renal function 1%
  • Dizziness 1%
  • Diarrhea 1%
  • Coughing 1%
  • Fatigue 1%
  • Flu-like symptoms 1%
More Inspra side effects »
How it works
AldactazideInspra
Aldactazide (Spironolactone / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure with two diuretics (water pills), hydrochlorothiazide and spironolactone. They act on different parts of your kidney to get rid of extra fluids.Inspra (eplerenone) is an aldosterone antagonist. It blocks aldosterone (a hormone) and helps your kidneys get rid of excess fluid in your body, which helps lower blood pressure.
Type of medication
AldactazideInspra
Prescription onlyPrescription only
Available as
AldactazideInspra
  • Pill
  • Pill
Used for
AldactazideInspra
Risk factors for serious side effects
AldactazideInspra
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
  • Medicine that affects electrolytes
Detailed Aldactazide (spironolactone / hydrochlorothiazide) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that lower your blood pressure
  • Current kidney problems
  • Medicines that increase potassium
  • Use of salt substitutes
Detailed Inspra (eplerenone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Kidneys and liver
AldactazideInspra
  • Aldactazide (Spironolactone / Hydrochlorothiazide) can increase the amount of potassium in your body. High potassium can cause heart problems. Baseline and routine blood tests are needed to monitor your potassium and kidney function.
  • Get your blood pressure, potassium, and kidney function checked one week after starting the medicine, then routinely after.
  • Needs blood tests to monitor electrolytes and kidney function.
  • Inspra (eplerenone) shouldn't be used by people with bad kidneys since it can hurt your kidneys or cause worse side effects, such as high potassium levels. Your doctor will do frequent blood tests to monitor your kidney function and electrolytes while you're on this drug.
  • Shouldn't be used by people with kidney or liver damage.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
Upsides and benefits
AldactazideInspra
  • Lowers the risk of heart attack and stroke.
  • Has a low risk of causing muscle problems due to low potassium levels in your blood.
  • Gets rid of extra fluids in your body.
  • Helpful for people who tend to have low potassium levels.
  • Lowers your blood pressure.
  • It can help remove fluid from your body when it's used with other drugs.
  • Reduces the risk of death in people with heart failure.
  • It can have fewer side effects than spironolactone.
Downsides and risks
AldactazideInspra
  • Many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • Needs blood tests to monitor electrolytes and kidney function.
  • Can make you urinate more often.
  • Can make you sensitive to sunlight.
  • Shouldn't take it if you have a sulfa allergy.
  • Inspra (eplerenone) isn't a first choice medicine for lowering blood pressure or getting rid of fluid in the body. It's usually used in combination with other medicines.
  • It can make you feel dizzy for the first few days. Be careful driving until you know how it affects you.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
  • It can be very expensive compared to spironolactone.
Tips from our pharmacists for people taking the medication
AldactazideInspra
  • Makes you urinate more often, so don't take it at bedtime.
  • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how it affects you.
  • Don't use supplements or salt substitutes that are high in potassium.
  • Get your blood pressure, potassium, and kidney function checked one week after starting the medicine, then routinely after.
  • Tell your doctor about any dizziness, muscle weakness, skin changes, red or black tarry stool.
  • Can make your skin more sensitive to sun, so use proper protections.
  • Inspra (eplerenone) can make you feel dizzy the first few days you're taking it.
  • It can increase your potassium to dangerous levels, so don't use salt substitutes or other products that contain potassium.
  • Women may notice breast tenderness or swelling and irregular periods.
  • Shouldn't be used by people with kidney or liver damage.
  • Your doctor will check the amount of potassium in your blood while you're on this drug.
Learn more
More about AldactazideSide effectsAlternativesFDA package insert
Have you used Aldactazide (spironolactone / hydrochlorothiazide)?
Worth itNot sureNot worth it
More about InspraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Inspra (eplerenone)?
Worth itNot sureNot worth it