Compare Aldactazide vs. Inspra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aldactazide (Spironolactone / Hydrochlorothiazide)

Prescription only

Inspra (eplerenone)

Prescription only
Lowers blood pressure. Removes extra water from your body.

Aldactazide (Spironolactone / Hydrochlorothiazide) removes excess fluid in your body and lowers your blood pressure, while helping keep your potassium levels safe.

Helps lower blood pressure and protect the heart in people with heart failure.

Inspra (eplerenone) lowers blood pressure and can help remove fluid when it's used with other drugs. It reduces the risk of death in people with heart failure and is usually used when people can't take spironolactone.

Upsides
  • Lowers the risk of heart attack and stroke.
  • Has a low risk of causing muscle problems due to low potassium levels in your blood.
  • Gets rid of extra fluids in your body.
  • Helpful for people who tend to have low potassium levels.
  • Lowers your blood pressure.
  • It can help remove fluid from your body when it's used with other drugs.
  • Reduces the risk of death in people with heart failure.
  • It can have fewer side effects than spironolactone.
Downsides
  • Many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • Needs blood tests to monitor electrolytes and kidney function.
  • Can make you urinate more often.
  • Can make you sensitive to sunlight.
  • Shouldn't take it if you have a sulfa allergy.
  • Inspra (eplerenone) isn't a first choice medicine for lowering blood pressure or getting rid of fluid in the body. It's usually used in combination with other medicines.
  • It can make you feel dizzy for the first few days. Be careful driving until you know how it affects you.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
  • It can be very expensive compared to spironolactone.
Used for
Dosage forms
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  • Pill
Price
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$68.4
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$39.26
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Side effects
The Aldactazide (Spironolactone / Hydrochlorothiazide) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • High potassium
    3%
  • Abnormal renal function
    3%
See more detailed side effects
Risks and warnings
  • Heart problems due to high potassium

    Current kidney problems

    ...and 2 more risk factors

  • Muscle problems due to electrolyte imbalance

    Current kidney problems

    ...and 1 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

See more detailed risks and warnings
  • Low blood pressure

    Taking with alcohol

    ...and 1 more risk factors

  • Heart problems from high potassium

    Current kidney problems

    ...and 3 more risk factors

  • Kidney problems

    Current kidney problems

  • Liver problems

    Liver damage

See more detailed risks and warnings