Compare Aldactone vs. Digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Removes extra water from your body. Aldactone (Spironolactone) is helpful when added to another diuretic to get rid of excess fluid in your body. Doesn't work well on its own.Improves heart pumping. Digoxin is a good backup for treating heart failure symptoms, but it doesn't, by itself, lower your risk of death.
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Reviews & ratings
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Reviews for Lanoxin (Digoxin)
+35% vs. Aldactone (Spironolactone)
Same vs. Aldactone (Spironolactone)
10% vs. Aldactone (Spironolactone)
Side effects

We haven’t found good data for Aldactone side effects.

FDA side effect reports for Aldactone »
  • Dizziness 1%
  • Side effects requiring hospitalization 1%
  • Nausea 1%
  • Death 1%
More Digoxin side effects »
How it works
Aldactone (Spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body.Digoxin helps your heart work more efficiently. It makes your heart pump slower and stronger, which helps it get more blood and oxygen out to your body and organs.
Type of medication
Prescription only
Prescription only
Available as
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
Risk factors for serious side effects
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
      Detailed Aldactone (Spironolactone) risks & warnings »
      • History of heart problems
      • Drug interactions
      • Wolff-Parkinson-White syndrome
      • Low body weight, advanced age, impaired renal function, electrolyte imbalances
      • Overactive or underactive thyroid
      • Aspirin allergy
      • Electrocardioversion
      Detailed Lanoxin (Digoxin) risks & warnings »
      Pregnancy category
      No specific alcohol-related info.No specific alcohol-related info.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Needs to have blood tests done to monitor electrolyte levels and kidney function.
      • Aldactone (Spironolactone) can increase the amount of potassium in your body. High potassium can cause heart problems. Baseline and routine blood tests are needed to monitor your potassium and kidney function.
      No specific kidneys and liver-related info.
      • You can have breast pain/swelling, irregular periods (women), or trouble with sexual performance.
      No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      • Has a low risk of causing muscle problems due to low potassium levels in your blood.
      • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
      • Can lower blood pressure.
      • Reduces the risk of death in people with heart failure.
      • Used for some abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
      • Relieves shortness of breath, and makes it easier to be active without having symptoms.
      • In studies, Digoxin lowered the risk of having to be admitted to the hospital for worsening heart failure.
      Downsides and risks
      • Not very good at getting rid of excess fluids on its own. Should be used with another drug to help get rid of excess fluids.
      • Has many possible side effects, especially when higher doses are used.
      • Can increase the risk of tumor growth.
      • Needs to have blood tests done to monitor electrolyte levels and kidney function.
      • For heart failure, relieves symptoms, but does not lower the risk of death. That's why it's usually used together with other heart failure medicines that do lower the risk of death.
      • Requires blood tests, especially during the first few weeks of treatment.
      Tips from our pharmacists for people taking the medication
      • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how the medicine affects you.
      • Don't use supplements or salt substitutes that are high in potassium.
      • You can have breast pain/swelling, irregular periods (women), or trouble with sexual performance.
      • Tell your doctor about any muscle weakness, skin changes, red or black tarry stool.
      • Can take 2 to 3 days to see full diuretic effects and 2 to 3 weeks to see blood pressure lowering effects.
      • Take it at the same time every day.
      • Drink plenty of water while taking this medicine.
      • Requires routine blood tests to make sure you have the right amount of Digoxin in your body.
      • Tell your doctor about other medicines you're taking to avoid drug interactions.
      Learn more
      More about AldactoneSide effectsReviews & ratingsAlternativesFDA package insert
      More about DigoxinSide effectsReviews & ratingsAlternativesFDA package insert