Compare spironolactone vs. Digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aldactone
(spironolactone)

Lanoxin
(digoxin)

Removes extra water from your body. Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.Improves heart pumping. Digoxin is a good backup for treating heart failure symptoms, but it doesn't, by itself, lower your risk of death.
Reviews & ratings
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Have you used Aldactone (spironolactone)?
Worth itNot sureNot worth it
Reviews for Digoxin
64%
-64% worse vs. spironolactone
43%
-43% worse vs. spironolactone
31%
+31% better vs. spironolactone
Have you used Lanoxin (digoxin)?
Worth itNot sureNot worth it
Side effects
spironolactoneDigoxin

The spironolactone FDA package insert doesn’t have numbers about how common side effects are.

More about spironolactone side effects »
  • Any side effect 20%
  • Dizziness 1%
  • Mental disturbances 4%
  • Nausea 1%
  • Diarrhea 3%
  • Death 1%
  • Side effects requiring hospitalization 1%
  • Abnormally fast heart beat 2%
  • Vomiting 2%
More Digoxin side effects »
How it works
spironolactoneDigoxin
Aldactone (spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body.Digoxin helps your heart work more efficiently. It makes your heart pump slower and stronger, which helps it get more blood and oxygen out to your body and organs.
Type of medication
spironolactoneDigoxin
Prescription onlyPrescription only
Available as
spironolactoneDigoxin
  • Pill
  • Pill
  • Liquid
Used for
spironolactoneDigoxin
Risk factors for serious side effects
spironolactoneDigoxin
  • Taking with alcohol
  • Taking other medicines that lower your blood pressure
  • Current kidney problems
  • Taking other medicines that increase potassium
  • Use of salt substitutes
Detailed Aldactone (spironolactone) risks & warnings »
  • History of heart problems
  • Drug interactions
  • Wolff-Parkinson-White syndrome
  • Low body weight, advanced age, impaired renal function, electrolyte imbalances
  • Overactive or underactive thyroid
Detailed Lanoxin (digoxin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
spironolactoneDigoxin
No interactions related info.
  • Tell your doctor about other medicines you're taking to avoid drug interactions.
Kidneys and liver
spironolactoneDigoxin
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
No kidneys and liver related info.
Pain
spironolactoneDigoxin
  • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
No pain related info.
Upsides and benefits
spironolactoneDigoxin
  • Has a low risk of causing muscle problems from low potassium levels in your blood.
  • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
  • Can lower blood pressure.
  • Reduces the risk of death in people with heart failure.
  • Used for some abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
  • Relieves shortness of breath, and makes it easier to be active without having symptoms.
  • In studies, Digoxin lowered the risk of having to be admitted to the hospital for worsening heart failure.
Downsides and risks
spironolactoneDigoxin
  • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
  • Has many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
  • For heart failure, relieves symptoms, but does not lower the risk of death. That's why it's usually used together with other heart failure medicines that do lower the risk of death.
  • Requires blood tests, especially during the first few weeks of treatment.
Tips from our pharmacists for people taking the medication
spironolactoneDigoxin
  • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how the medicine affects you.
  • Don't use supplements or salt substitutes that are high in potassium.
  • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
  • Tell your doctor about any muscle weakness, skin changes, and red or black tarry stool.
  • You will urinate more often within 2 to 3 days, and will have lower blood pressure in 2 to 3 weeks.
  • Take it at the same time every day.
  • Drink plenty of water while taking this medicine.
  • Requires routine blood tests to make sure you have the right amount of Digoxin in your body.
  • Tell your doctor about other medicines you're taking to avoid drug interactions.
Learn more
More about spironolactoneSide effectsAlternativesFDA package insert
Have you used Aldactone (spironolactone)?
Worth itNot sureNot worth it
More about DigoxinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lanoxin (digoxin)?
Worth itNot sureNot worth it