Compare spironolactone vs. Inspra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aldactone
(spironolactone)

Inspra
(eplerenone)

Removes extra water from your body. Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.Helps lower blood pressure and protect the heart in people with heart failure. Inspra (eplerenone) lowers blood pressure and can help remove fluid when it's used with other drugs. It reduces the risk of death in people with heart failure and is usually used when people can't take spironolactone.
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Coupons for spironolactone
Best available price for 30 (25mg) tablets of spironolactone
Coupons for Inspra
Best available price for 30 (25mg) tablets of inspra
Reviews & ratings
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Have you used Aldactone (spironolactone)?
Worth itNot sureNot worth it

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Have you used Inspra (eplerenone)?
Worth itNot sureNot worth it
Side effects
spironolactoneInspra

The spironolactone FDA package insert doesn’t have numbers about how common side effects are.

More about spironolactone side effects »
  • High potassium 1%
  • Abnormal renal function 1%
  • Dizziness 1%
  • Diarrhea 1%
  • Coughing 1%
  • Fatigue 1%
  • Flu-like symptoms 1%
More Inspra side effects »
How it works
spironolactoneInspra
Aldactone (spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body.Inspra (eplerenone) is an aldosterone antagonist. It blocks aldosterone (a hormone) and helps your kidneys get rid of excess fluid in your body, which helps lower blood pressure.
Type of medication
spironolactoneInspra
Prescription onlyPrescription only
Available as
spironolactoneInspra
  • Pill
  • Pill
Used for
spironolactoneInspra
Risk factors for serious side effects
spironolactoneInspra
  • Taking with alcohol
  • Taking other medicines that lower your blood pressure
  • Current kidney problems
  • Taking other medicines that increase potassium
  • Use of salt substitutes
Detailed Aldactone (spironolactone) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that lower your blood pressure
  • Current kidney problems
  • Medicines that increase potassium
  • Use of salt substitutes
Detailed Inspra (eplerenone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Kidneys and liver
spironolactoneInspra
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
  • Inspra (eplerenone) shouldn't be used by people with bad kidneys since it can hurt your kidneys or cause worse side effects, such as high potassium levels. Your doctor will do frequent blood tests to monitor your kidney function and electrolytes while you're on this drug.
  • Shouldn't be used by people with kidney or liver damage.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
Pain
spironolactoneInspra
  • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
No pain related info.
Upsides and benefits
spironolactoneInspra
  • Has a low risk of causing muscle problems from low potassium levels in your blood.
  • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
  • Can lower blood pressure.
  • Reduces the risk of death in people with heart failure.
  • Lowers your blood pressure.
  • It can help remove fluid from your body when it's used with other drugs.
  • Reduces the risk of death in people with heart failure.
  • It can have fewer side effects than spironolactone.
Downsides and risks
spironolactoneInspra
  • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
  • Has many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
  • Inspra (eplerenone) isn't a first choice medicine for lowering blood pressure or getting rid of fluid in the body. It's usually used in combination with other medicines.
  • It can make you feel dizzy for the first few days. Be careful driving until you know how it affects you.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
  • It can be very expensive compared to spironolactone.
Tips from our pharmacists for people taking the medication
spironolactoneInspra
  • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how the medicine affects you.
  • Don't use supplements or salt substitutes that are high in potassium.
  • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
  • Tell your doctor about any muscle weakness, skin changes, and red or black tarry stool.
  • You will urinate more often within 2 to 3 days, and will have lower blood pressure in 2 to 3 weeks.
  • Inspra (eplerenone) can make you feel dizzy the first few days you're taking it.
  • It can increase your potassium to dangerous levels, so don't use salt substitutes or other products that contain potassium.
  • Women may notice breast tenderness or swelling and irregular periods.
  • Shouldn't be used by people with kidney or liver damage.
  • Your doctor will check the amount of potassium in your blood while you're on this drug.
Learn more
More about spironolactoneSide effectsAlternativesFDA package insert
Have you used Aldactone (spironolactone)?
Worth itNot sureNot worth it
More about InspraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Inspra (eplerenone)?
Worth itNot sureNot worth it