Compare spironolactone vs. Inspra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aldactone (spironolactone)

Prescription only

Inspra (eplerenone)

Prescription only
Removes extra water from your body.

Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.

Helps lower blood pressure and protect the heart in people with heart failure.

Inspra (eplerenone) lowers blood pressure and can help remove fluid when it's used with other drugs. It reduces the risk of death in people with heart failure and is usually used when people can't take spironolactone.

Upsides
  • Has a low risk of causing muscle problems from low potassium levels in your blood.
  • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
  • Can lower blood pressure.
  • Reduces the risk of death in people with heart failure.
  • Lowers your blood pressure.
  • It can help remove fluid from your body when it's used with other drugs.
  • Reduces the risk of death in people with heart failure.
  • It can have fewer side effects than spironolactone.
Downsides
  • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
  • Has many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
  • Inspra (eplerenone) isn't a first choice medicine for lowering blood pressure or getting rid of fluid in the body. It's usually used in combination with other medicines.
  • It can make you feel dizzy for the first few days. Be careful driving until you know how it affects you.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
  • It can be very expensive compared to spironolactone.
Used for
Dosage forms
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Side effects
The Aldactone (spironolactone) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • High potassium
    3%
  • Abnormal renal function
    3%
See more detailed side effects
Risks and warnings
  • Low blood pressure

    Taking with alcohol

    ...and 1 more risk factors

  • Heart problems from high potassium

    Current kidney problems

    ...and 2 more risk factors

See more detailed risks and warnings
  • Low blood pressure

    Taking with alcohol

    ...and 1 more risk factors

  • Heart problems from high potassium

    Current kidney problems

    ...and 3 more risk factors

  • Kidney problems

    Current kidney problems

  • Liver problems

    Liver damage

See more detailed risks and warnings