Compare Alka-Seltzer Plus Cold and Cough vs. Advil PM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Plus Cold And Cough
(Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine)

Advil Pm
(Diphenhydramine / Ibuprofen)

Relieves coughing and cold symptoms. Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves pain and helps you sleep. Advil Pm (Diphenhydramine / Ibuprofen) works well at relieving pain and also helps you sleep.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Alka-Seltzer Plus Cold and CoughAdvil PM

We haven’t found good data for Alka-Seltzer Plus Cold and Cough side effects.

FDA side effect reports for Alka-Seltzer Plus Cold and Cough »

We haven’t found good data for Advil PM side effects.

FDA side effect reports for Advil PM »
How it works
Alka-Seltzer Plus Cold and CoughAdvil PM
Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Aspirin relieves pain and reduces fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Advil Pm (Diphenhydramine / Ibuprofen) is a combination medicine that treats cold and flu symptoms. Ibuprofen is an NSAID that relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.
Type of medication
Alka-Seltzer Plus Cold and CoughAdvil PM
Pain reliever
Salicylate
Antihistamine
1st generation
Cough suppressantDecongestantOver-the-counter
Antihistamine
1st generation
Pain reliever
NSAID
Over-the-counter
Available as
Alka-Seltzer Plus Cold and CoughAdvil PM
  • Pill
  • Effervescent tablet
  • Pill
Used for (click to learn more)
Alka-Seltzer Plus Cold and CoughAdvil PM
Risk factors for serious side effects
Alka-Seltzer Plus Cold and CoughAdvil PM
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Women of childbearing age
  • Age 18 years or younger
  • History of high blood pressure
  • Taking MAO inhibitors
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
  • Taking with aspirin
  • Age 65 years or older
  • High blood pressure
  • Heart disease
  • Kidney disease
  • History of falls
  • Age 65 or older
  • Taking other drugs that make you drowsy or dizzy
Detailed Advil Pm (Diphenhydramine / Ibuprofen) risks & warnings »
Pregnancy category
Alka-Seltzer Plus Cold and CoughAdvil PM
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
Food
No specific food-related info.
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
  • Diphenhydramine, also known as Benadryl, is an antihistamine in Advil Pm (Diphenhydramine / Ibuprofen) that can make you feel dizzy or drowsy. People who are at a higher risk of falls should avoid using Advil Pm (Diphenhydramine / Ibuprofen).
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Alka-Seltzer Plus Cold and CoughAdvil PM
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Phenylephrine (the decongestant ingredient) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Dextromethorphan (the cough suppressant ingredient) works well and has very few side effects.
  • Advil Pm (Diphenhydramine / Ibuprofen) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
Downsides and risks
Alka-Seltzer Plus Cold and CoughAdvil PM
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The aspirin in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) interacts with many other drugs and health conditions.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can only take one dose in 24 hours.
  • Can increase the risk of falls, so elderly people shouldn't use it.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Cold and CoughAdvil PM
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Chlorpheniramine (the antihistamine in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Don't take Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) if you're pregnant.
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) if you're pregnant.
Learn more
More about Alka-Seltzer Plus Cold and CoughSide effectsReviews & ratingsAlternativesFDA package insert
More about Advil PMSide effectsReviews & ratingsAlternativesFDA package insert