Compare Alka-Seltzer Plus Day Cold and Flu vs. Alka-Seltzer Plus Cold and Cough

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Plus Day Cold And Flu
(Acetaminophen / Dextromethorphan / Phenylephrine)

Alka-Seltzer Plus Cold And Cough
(Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine)

Relieves cold and flu symptoms. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves coughing and cold symptoms. Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough

We haven’t found good data for Alka-Seltzer Plus Day Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Cold and Flu »

We haven’t found good data for Alka-Seltzer Plus Cold and Cough side effects.

FDA side effect reports for Alka-Seltzer Plus Cold and Cough »
How it works
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough
Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Aspirin relieves pain and reduces fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
Pain reliever
Salicylate
Antihistamine
1st generation
Cough suppressantDecongestantOver-the-counter
Available as
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough
  • Pill
  • Pill
  • Effervescent tablet
Used for (click to learn more)
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough
Risk factors for serious side effects
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Women of childbearing age
  • Age 18 years or younger
  • History of high blood pressure
  • Taking MAO inhibitors
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) risks & warnings »
Pregnancy category
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Phenylephrine (the decongestant ingredient) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Dextromethorphan (the cough suppressant ingredient) works well and has very few side effects.
Downsides and risks
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The aspirin in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) interacts with many other drugs and health conditions.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Day Cold and FluAlka-Seltzer Plus Cold and Cough
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Chlorpheniramine (the antihistamine in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • Don't take Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) if you're pregnant.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Alka-Seltzer Plus Day Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
More about Alka-Seltzer Plus Cold and CoughSide effectsReviews & ratingsAlternativesFDA package insert