Compare Alka-Seltzer Plus Day Cold And Flu vs. Dayquil Cold And Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Plus Day Cold And Flu
(acetaminophen / dextromethorphan / phenylephrine)

Dayquil Cold And Flu
(acetaminophen / phenylephrine / dextromethorphan)

Relieves cold and flu symptoms. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a useful combination medicine that relieves cold and flu symptoms, but make sure you really need all of its ingredients.
Reviews & ratings
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Have you used Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Dayquil Cold And Flu
81%
-31% worse vs. Alka-Seltzer Plus Day Cold And Flu
38%
+12% better vs. Alka-Seltzer Plus Day Cold And Flu
5%
-20% worse vs. Alka-Seltzer Plus Day Cold And Flu
1034 reviews
Have you used Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)?
Worth itNot sureNot worth it
Side effects
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu

We haven’t found good data for Alka-Seltzer Plus Day Cold And Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Cold And Flu »

We haven’t found good data for Dayquil Cold And Flu side effects.

FDA side effect reports for Dayquil Cold And Flu »
How it works
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
Over-the-counterOver-the-counter
Available as
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
  • Pill
  • Pill
  • Liquid
Used for
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
Risk factors for serious side effects
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Kidneys and liver
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Upsides and benefits
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Downsides and risks
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Day Cold And FluDayquil Cold And Flu
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Follow age-specific dosing instructions on how much to take.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Alka-Seltzer Plus Day Cold And FluSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
More about Dayquil Cold And FluSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)?
Worth itNot sureNot worth it