Compare Alka-Seltzer Plus Day Cold and Flu vs. Phenylephrine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Plus Day Cold And Flu
(Acetaminophen / Dextromethorphan / Phenylephrine)

Sudafed Pe
(Phenylephrine)

Relieves cold and flu symptoms. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Clears your sinuses. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.
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Reviews & ratings
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Reviews for Sudafed Pe (Phenylephrine)
44%
56% vs. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine)
23%
77% vs. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine)
10%
10% vs. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine)
Side effects
Alka-Seltzer Plus Day Cold and FluPhenylephrine

We haven’t found good data for Alka-Seltzer Plus Day Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Cold and Flu »

We haven’t found good data for Phenylephrine side effects.

FDA side effect reports for Phenylephrine »
How it works
Alka-Seltzer Plus Day Cold and FluPhenylephrine
Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Sudafed Pe (Phenylephrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.
Type of medication
Alka-Seltzer Plus Day Cold and FluPhenylephrine
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
DecongestantPrescription or OTC
Available as
Alka-Seltzer Plus Day Cold and FluPhenylephrine
  • Pill
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
Used for (click to learn more)
Alka-Seltzer Plus Day Cold and FluPhenylephrine
Risk factors for serious side effects
Alka-Seltzer Plus Day Cold and FluPhenylephrine
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) risks & warnings »
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of heart problems
  • Age 65 years or older
  • Women of childbearing age
Detailed Sudafed Pe (Phenylephrine) risks & warnings »
Pregnancy category
Alka-Seltzer Plus Day Cold and FluPhenylephrine
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.
  • Shouldn't use it before you want to sleep.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Alka-Seltzer Plus Day Cold and FluPhenylephrine
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
Downsides and risks
Alka-Seltzer Plus Day Cold and FluPhenylephrine
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • You shouldn't use it if you have high blood pressure.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
  • You shouldn't use it if you have high blood pressure.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Day Cold and FluPhenylephrine
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Starts working in 30 minutes.
  • Phenylephrine can make you restless, so don't take it too close to bedtime.
  • It's in other cold and flu combination medicines. Read labels closely so you don't accidentally double up and take too much of it in a day.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about Alka-Seltzer Plus Day Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
More about PhenylephrineSide effectsReviews & ratingsAlternativesFDA package insert