Compare Alka-Seltzer Plus Day Cold And Flu vs. Robitussin DM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves cold and flu symptoms.

Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.

Breaks up mucus and relieves cough.

Robitussin Dm (Guaifenesin / Dextromethorphan) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. You have to take it more often than other guaifenesin products.

3.7/ 5 average rating with 724 reviewsforRobitussin DM
Upsides
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • Robitussin Dm (Guaifenesin / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
  • Helps loosen the mucus and phlegm that builds up and causes productive, wet coughs.
Downsides
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • Robitussin Dm (Guaifenesin / Dextromethorphan) isn’t useful if you have a dry cough without mucus or phlegm.
  • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Robitussin Dm (Guaifenesin / Dextromethorphan)) stops you from coughing.
  • Needs to be taken more often during the day than other products with guaifenesin, like Mucinex.
  • Can cause sleepiness, dizziness, and an upset stomach.
Used for
Dosage forms
  • Pill
  • Liquid
No pricing information available
No pricing information available
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Reviews
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724 reviews so far
75%
saidit'sworth it
37%
saiditworked well
7%
saidit'sa big hassle

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Side effects
The Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Robitussin Dm (Guaifenesin / Dextromethorphan) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Chronic cough from an infection
    • History of chronic obstructive pulmonary disease (COPD)
    • History of smoking
  • Serotonin syndrome
    • Using other medications that affect serotonin
See more detailed risks and warnings
  • Nausea and vomiting
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Cough warning
See more detailed risks and warnings