Compare Alka-Seltzer Plus Day Cold and Flu vs. Tylenol Cold and Flu Severe

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Plus Day Cold And Flu
(Acetaminophen / Dextromethorphan / Phenylephrine)

Tylenol Cold And Flu Severe
(Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin)

Relieves cold and flu symptoms. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is an okay combination medicine that relieves cold and flu symptoms, so make sure you really need all of its ingredients.
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Side effects
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe

We haven’t found good data for Alka-Seltzer Plus Day Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Cold and Flu »

We haven’t found good data for Tylenol Cold and Flu Severe side effects.

FDA side effect reports for Tylenol Cold and Flu Severe »
How it works
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe
Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Guaifenesin is an expectorant that breaks up and thins out mucus.
Type of medication
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
Pain reliever
APAP
DecongestantCough suppressantExpectorantOver-the-counter
Available as
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe
Risk factors for serious side effects
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • Using other medications that affect serotonin
  • Women of childbearing age
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
Detailed Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) risks & warnings »
Pregnancy category
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides and risks
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Day Cold and FluTylenol Cold and Flu Severe
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Don't crush, chew, or dissolve the caplets.
  • Follow age-specific dosing instructions on how much to take.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Alka-Seltzer Plus Day Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
More about Tylenol Cold and Flu SevereSide effectsReviews & ratingsAlternativesFDA package insert