Compare Alka-Seltzer Plus Day Cold And Flu vs. Tylenol Cold Multi-Symptom Daytime

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Plus Day Cold And Flu
(acetaminophen / dextromethorphan / phenylephrine)

Tylenol Cold Multi-Symptom Daytime
(acetaminophen / dextromethorphan / phenylephrine)

Relieves cold and flu symptoms. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.
Reviews & ratings
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Have you used Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)?
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)?
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Side effects
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime

We haven’t found good data for Alka-Seltzer Plus Day Cold And Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Cold And Flu »

We haven’t found good data for Tylenol Cold Multi-Symptom Daytime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Daytime »
How it works
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
Over-the-counterOver-the-counter
Available as
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
  • Pill
  • Pill
  • Liquid
  • Powder
Used for
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
Risk factors for serious side effects
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
  • Taking with alcohol
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Kidneys and liver
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Upsides and benefits
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Downsides and risks
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Day Cold And FluTylenol Cold Multi-Symptom Daytime
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Alka-Seltzer Plus Day Cold And FluSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)?
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More about Tylenol Cold Multi-Symptom DaytimeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it