Compare Alka-Seltzer Plus Night Cold And Flu vs. Tylenol PM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)

Over-the-counter
Relieves cold and flu symptoms, and helps you sleep.

Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms at night, but it's more medicine than you need if you only have one symptom.

Relieves pain and helps you sleep.

Tylenol Pm (Acetaminophen / Diphenhydramine) works well at relieving pain and also helps you sleep.

Upsides
  • Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough suppressant (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) can help you sleep.
  • Tylenol Pm (Acetaminophen / Diphenhydramine) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
Downsides
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Can only take one dose in 24 hours.
Used for
Dosage forms
  • Pill
  • Pill
No pricing information available
No pricing information available
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Side effects
The Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Tylenol Pm (Acetaminophen / Diphenhydramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    Drinking more than 2 alcoholic beverages a day

    ...and 2 more risk factors

  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Chronic cough from an infection

    History of chronic obstructive pulmonary disease (COPD)

    ...and 1 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Antihistamine side effects

    Age 65 years or older

    ...and 2 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

See more detailed risks and warnings
  • Increased falls

    History of falls

    ...and 2 more risk factors

  • Liver damage

    Drinking more than 3 alcoholic beverages a day

    ...and 2 more risk factors

  • Antihistamine side effects

    Age 65 years or older

    ...and 2 more risk factors

See more detailed risks and warnings