Compare Alka-Seltzer Plus Night Severe Cold and Flu vs. Nyquil Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Plus Night Severe Cold And Flu
(Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Relieves cold and flu symptoms, and helps you sleep. Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms at night, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
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Reviews & ratings
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Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
17% vs. Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)
42%
58% vs. Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)
6%
6% vs. Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)
Side effects
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu

We haven’t found good data for Alka-Seltzer Plus Night Severe Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Night Severe Cold and Flu »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »
How it works
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu
Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu
Pain reliever
Acetaminophen (APAP)
Antihistamine
Ethanolamine derivative
Cough suppressantDecongestantOver-the-counter
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
Available as
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu
  • Powder
  • Pill
  • Liquid
Used for (click to learn more)
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu
Risk factors for serious side effects
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
Pregnancy category
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.
  • Avoid using alcohol and other drugs that make you drowsy.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • The antihistamine (doxylamine) can help you sleep.
  • The antihistamine (doxylamine) will help you sleep.
  • Avoid using alcohol and other drugs that make you drowsy.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu
  • Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The antihistamine (doxylamine) can help you sleep.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The antihistamine (doxylamine) will help you sleep.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Downsides and risks
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Night Severe Cold and FluNyquil Cold and Flu
  • Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) comes as a powder packet you can dissolve in hot water and drink.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Alka-Seltzer Plus Night Severe Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
More about Nyquil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert