Compare Alka-Seltzer Plus Night Severe Cold and Flu vs. Tylenol PM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Plus Night Severe Cold And Flu
(Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)

Tylenol Pm
(Acetaminophen / Diphenhydramine)

Relieves cold and flu symptoms, and helps you sleep. Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms at night, but it's more medicine than you need if you only have one symptom.Relieves pain and helps you sleep. Tylenol Pm (Acetaminophen / Diphenhydramine) works well at relieving pain and also helps you sleep.
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Side effects
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM

We haven’t found good data for Alka-Seltzer Plus Night Severe Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Night Severe Cold and Flu »

We haven’t found good data for Tylenol PM side effects.

FDA side effect reports for Tylenol PM »
How it works
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM
Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.Tylenol Pm (Acetaminophen / Diphenhydramine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.
Type of medication
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM
Pain reliever
Acetaminophen (APAP)
Antihistamine
Ethanolamine derivative
Cough suppressantDecongestantOver-the-counter
Pain reliever
Acetaminophen (APAP)
Antihistamine
1st generation
Over-the-counter
Available as
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM
  • Powder
  • Pill
Used for (click to learn more)
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM
Risk factors for serious side effects
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) risks & warnings »
  • History of falls
  • Age 65 or older
  • Taking other drugs that make you drowsy or dizzy
  • Drinking more than 3 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
Detailed Tylenol Pm (Acetaminophen / Diphenhydramine) risks & warnings »
Pregnancy category
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • The antihistamine (doxylamine) can help you sleep.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • Diphenhydramine, also known as Benadryl, is an antihistamine in Tylenol Pm (Acetaminophen / Diphenhydramine) that can make you feel dizzy or drowsy. People who are at a higher risk of falls should avoid using Tylenol Pm (Acetaminophen / Diphenhydramine).
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM
  • Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) can help you sleep.
  • Tylenol Pm (Acetaminophen / Diphenhydramine) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
Downsides and risks
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • Can only take one dose in 24 hours.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Night Severe Cold and FluTylenol PM
  • Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) comes as a powder packet you can dissolve in hot water and drink.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
Learn more
More about Alka-Seltzer Plus Night Severe Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
More about Tylenol PMSide effectsReviews & ratingsAlternativesFDA package insert