Compare Alka-Seltzer vs. Imodium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves heartburn, headache, and body pains.

Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.

3.9/ 5 average rating with 1055 reviewsforAlka-Seltzer
Treats diarrhea.

One day is too many days to have diarrhea. Having Imodium (Loperamide) on hand to relieve your symptoms can be a life-saver.

4.2/ 5 average rating with 285 reviewsforImodium
Upsides
  • Works great if you have an upset stomach and a headache or body pain at the same time.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
  • Most people who take Imodium feel there's no hassle and it's definitely worth it!
  • Non-habit forming and available over-the-counter.
  • It comes in caplets, liquid, and chewable tablets so you can use it anywhere you need it.
  • Imodium is used for short-term, chronic and traveler's diarrhea. It's also used for people who have diarrhea caused by cancer or certain medicines that treat cancer.
Downsides
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
  • Can't be used by people with allergy to aspirin.
  • You may not like the taste or fizz.
  • Imodium only treats your diarrhea symptoms. Diarrhea may be caused by a number of conditions and will need specific treatment that deals with the underlying issue.
  • Studies in people taking Imodium for chronic diarrhea showed if the maximum number of doses didn't relieve symptoms in 10 days, then it probably won't work for that condition. You can talk to your doctor about other treatment options.
Used for
Dosage forms
  • Chewable tablet
  • Effervescent tablet
  • Pill
  • Chewable tablet
  • Liquid
Price
No pricing information available
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Reviews
1055 reviews so far
81%
saidit'sworth it
52%
saiditworked well
8%
saidit'sa big hassle

Have you used Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate)?

Leave a review
285 reviews so far
89%
saidit'sworth it
65%
saiditworked well
6%
saidit'sa big hassle

Have you used Imodium (Loperamide)?

Leave a review
Side effects
The Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Constipation
    3%
See more detailed side effects
Risks and risk factors
  • Taking the wrong medication
  • High blood sodium levels
    • Current kidney disease
    • Kidney dialysis
    • Age 65 or older
  • May worsen heart or kidney problems
    • Congestive heart failure (CHF)
    • High blood pressure
    • Current kidney disease
    • Kidney dialysis
  • Brain damage or death from Reye's Syndrome
    • Children 18 years or younger recovering from viral infections
  • Stomach Bleeding
    • History of stomach bleeding or ulcers
    • Age 60 or older
    • Also taking other blood thinners
    • Drinking 3 or more alcoholic drinks a day
  • Serious allergic reactions
    • Asthma
    • Rhinitis
    • Nasal Polyps
    • Aspirin Allergy
    • NSAID Allergy
  • Harm to unborn babies
See more detailed risks and warnings
  • Allergic reactions
    • Allergy to loperamide
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Liver problems
    • Current liver problems
  • Serious intestinal problems
    • Taking HIV medicines
    • Active infectious colitis
  • Risk to fetus
    • Women of childbearing age
See more detailed risks and warnings