Compare Alka-Seltzer vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate)

Over-the-counter
Relieves heartburn, headache, and body pains.

Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.

5.4/ 7 average rating with 1055 reviewsforAlka-Seltzer
Relieves heartburn and indigestion.

Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.

4.6/ 7 average rating with 213 reviewsforMaalox
Upsides
  • Works great if you have an upset stomach and a headache or body pain at the same time.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
  • Works quickly.
  • Inexpensive and available over-the-counter.
  • Is one of the first choice medications for heartburn relief if you are pregnant.
Downsides
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
  • Can't be used by people with allergy to aspirin.
  • You may not like the taste or fizz.
  • Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
  • Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.
Used for
Dosage forms
  • Chewable tablet
  • Effervescent tablet
  • Chewable tablet
  • Liquid
No pricing information available
No pricing information available
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Reviews
1055 
81%
think this treatment is worth it
52%
think this treatment works well
8%
think this treatment is a hassle

Have you used Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate)?

Leave a review
213 
69%
think this treatment is worth it
30%
think this treatment works well
9%
think this treatment is a hassle

Have you used Maalox (aluminum / magnesium / simethicone)?

Leave a review
Side effects
The Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
The Maalox (aluminum / magnesium / simethicone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • High blood sodium levels

    Current kidney disease

    ...and 2 more risk factors

  • May worsen heart or kidney problems

    Congestive heart failure (CHF)

    ...and 3 more risk factors

  • Brain damage or death from Reye's Syndrome

    Children 18 years or younger recovering from viral infections

  • Stomach Bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Serious allergic reactions

    Asthma

    ...and 4 more risk factors

See more detailed risks and warnings
  • Aluminum and magnesium overdose

    Kidney problems

    ...and 1 more risk factors

See more detailed risks and warnings